High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.

Detalhes bibliográficos
Autor(a) principal: Guimarães, Monick Lindenmeyer
Data de Publicação: 2002
Outros Autores: Moreira, Aline dos Santos, Loureiro, Regina, Castro Filho, Bernardo Galvão, Morgado, Mariza Gonçalves
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8138
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil
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spelling Guimarães, Monick LindenmeyerMoreira, Aline dos SantosLoureiro, ReginaCastro Filho, Bernardo GalvãoMorgado, Mariza Gonçalves2014-08-06T14:08:08Z2014-08-06T14:08:08Z2002GUIMARÃES, L. M. et al. High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions. AIDS Research and Human Retroviruses, v. 18, n. 17, p. 1261-1269, 2002.0889-2229https://www.arca.fiocruz.br/handle/icict/8138engMary Ann Liebert, IncHigh frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, BrasilPublic Healthy Secretariat of RS State. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, BrasilWe describe the genetic variability of HIV-1 subtypes and recombinant genomes in samples from southeastern and southern Brazilian regions. Phylogenetic analysis of a subset of 34 samples (8F, 7B, 7C, 2D, 1A, and 9 B0 variant) based on the DNA sequencing of the env gp120 and gp41, gag p17, and nef regions confirmed the presence of nine (26.5%) potentially HIV-1 recombinant genomes. From the eight C2–V3 gp120 subtype F samples, only two seem to be pure F. One of the samples, classified as B0 in the C2–V3 gp120 and as B in gp41 had the gag and nef regions clustering with subtype C. Two of seven C2–V3 subtype C samples presented distinct recombinant patterns as Bgag/Cenv/Bnef and Bgag/Cenv/Cnef. Putative recombinant breakpoints were obtained for three samples presenting discordant subtypes (F/B) between gp120 and gp41 env fragments showing that similar breakpoints could be observed between two unlinked samples (95BRRJ014 and 96BRRJ101). A higher degree of polymorphism was verified in the analysis of a subtype A sample (98BRRS058) in the C2–V3/gp41 env fragment. The intrasubtype C distance was found to be lower than that found for the other subtypes for all genomic regions. These data confirm that distinct HIV-1 subtypes and recombinant forms are actively participating in the Brazilian AIDS epidemic, and that the subtype C was introduced more recently into southern Brazil.Genoma ViralHIV-1/classificaçãoHIV-1/genéticaRecombinação GenéticaSequência de BasesBrasilFrequência do GeneProteína gp120 do Envelope de HIV/genéticaProteína gp41 do Envelope de HIV/genéticaDados de Sequência MolecularFilogeniainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALGuimaraes LM High Frequency....pdfGuimaraes LM High Frequency....pdfapplication/pdf547447https://www.arca.fiocruz.br/bitstream/icict/8138/1/Guimaraes%20LM%20High%20Frequency....pdf4fc65ddf3bb5fc1bbe9880a9fad4877fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8138/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTGuimaraes LM High Frequency....pdf.txtGuimaraes LM High Frequency....pdf.txtExtracted texttext/plain36882https://www.arca.fiocruz.br/bitstream/icict/8138/3/Guimaraes%20LM%20High%20Frequency....pdf.txtd1c8dc823ffc08c6360e0c4e20ce8a5aMD53icict/81382023-03-15 14:33:56.431oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
title High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
spellingShingle High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
Guimarães, Monick Lindenmeyer
Genoma Viral
HIV-1/classificação
HIV-1/genética
Recombinação Genética
Sequência de Bases
Brasil
Frequência do Gene
Proteína gp120 do Envelope de HIV/genética
Proteína gp41 do Envelope de HIV/genética
Dados de Sequência Molecular
Filogenia
title_short High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
title_full High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
title_fullStr High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
title_full_unstemmed High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
title_sort High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions.
author Guimarães, Monick Lindenmeyer
author_facet Guimarães, Monick Lindenmeyer
Moreira, Aline dos Santos
Loureiro, Regina
Castro Filho, Bernardo Galvão
Morgado, Mariza Gonçalves
author_role author
author2 Moreira, Aline dos Santos
Loureiro, Regina
Castro Filho, Bernardo Galvão
Morgado, Mariza Gonçalves
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Monick Lindenmeyer
Moreira, Aline dos Santos
Loureiro, Regina
Castro Filho, Bernardo Galvão
Morgado, Mariza Gonçalves
dc.subject.decs.pt_BR.fl_str_mv Genoma Viral
HIV-1/classificação
HIV-1/genética
Recombinação Genética
Sequência de Bases
Brasil
Frequência do Gene
Proteína gp120 do Envelope de HIV/genética
Proteína gp41 do Envelope de HIV/genética
Dados de Sequência Molecular
Filogenia
topic Genoma Viral
HIV-1/classificação
HIV-1/genética
Recombinação Genética
Sequência de Bases
Brasil
Frequência do Gene
Proteína gp120 do Envelope de HIV/genética
Proteína gp41 do Envelope de HIV/genética
Dados de Sequência Molecular
Filogenia
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Department of Immunology. Rio de Janeiro, RJ, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2014-08-06T14:08:08Z
dc.date.available.fl_str_mv 2014-08-06T14:08:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIMARÃES, L. M. et al. High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions. AIDS Research and Human Retroviruses, v. 18, n. 17, p. 1261-1269, 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8138
dc.identifier.issn.none.fl_str_mv 0889-2229
identifier_str_mv GUIMARÃES, L. M. et al. High frequency of recombinant genomes in HIV type 1 samples from Brazilian southeastern and southern regions. AIDS Research and Human Retroviruses, v. 18, n. 17, p. 1261-1269, 2002.
0889-2229
url https://www.arca.fiocruz.br/handle/icict/8138
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert, Inc
publisher.none.fl_str_mv Mary Ann Liebert, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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