Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo

Detalhes bibliográficos
Autor(a) principal: Lopes, Stefanie C. P.
Data de Publicação: 2009
Outros Autores: Blanco, Yara C., Justo, Giselle Z., Nogueira, Paulo Afonso, Rodrigues, Francisco L. S., Goelnitz, Uta, Wunderlich, Gerhard, Facchini, Gustavo, Brocchi, Marcelo, Duran, Nelson, Costa, Fabio T. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1918
Resumo: Universidade Estadual de Campinas. Departamento de Microbiologia e Imunologia. Instituto de Biologia. Campinas, SP, Brasil.
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spelling Lopes, Stefanie C. P.Blanco, Yara C.Justo, Giselle Z.Nogueira, Paulo AfonsoRodrigues, Francisco L. S.Goelnitz, UtaWunderlich, GerhardFacchini, GustavoBrocchi, MarceloDuran, NelsonCosta, Fabio T. M.2011-04-15T14:09:18Z2011-04-15T14:09:18Z2009LOPES, Stefanie C. P. et al. Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo. Antimicrob Agents Chemother. v. 53, n 5, p. 2149-2152, May 2009.0066-4804https://www.arca.fiocruz.br/handle/icict/191810.1128/AAC.00693-08engViolacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Campinas. Departamento de Microbiologia e Imunologia. Instituto de Biologia. Campinas, SP, Brasil.Universidade Estadual de Campinas. Departamento de Microbiologia e Imunologia. Instituto de Biologia. Campinas, SP, Brasil.Universidade Federal de São Paulo. Departamento de Bioquímica. São Paulo, SP, Brasil.CEPEM. Porto Velho, RO, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Leônidas & Maria Deane. Laboratório de Biodiversidade em Saúde. Manaus, AM, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade Estadual de Campinas. Instituto de Química. Laboratório de Química Biológica. Campinas, SP, Brasil.Universidade Estadual de Campinas. Departamento de Microbiologia e Imunologia. Instituto de Biologia. Campinas, SP, Brasil.Universidade Estadual de Campinas. Instituto de Química. Laboratório de Química Biológica. Campinas, SP, Brasil.Universidade Estadual de Campinas. Departamento de Microbiologia e Imunologia. Instituto de Biologia. Campinas, SP, Brasil.Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudiinfected mice from a lethal challenge.ViolaceinChromobacterium ViolaceumAmazon River (Brazil)Plasmodium ParasitesResearch Studyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALViolacein Extracted from.pdfViolacein Extracted from.pdfapplication/pdf990010https://www.arca.fiocruz.br/bitstream/icict/1918/1/Violacein%20Extracted%20from.pdf23e829c9312411d1aec7b9aed520cb3bMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/1918/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTViolacein Extracted from.pdf.txtViolacein Extracted from.pdf.txtExtracted texttext/plain16279https://www.arca.fiocruz.br/bitstream/icict/1918/5/Violacein%20Extracted%20from.pdf.txt93340ca60325c512ef3cfa7a41a26753MD55THUMBNAILViolacein Extracted from.pdf.jpgViolacein Extracted from.pdf.jpgGenerated Thumbnailimage/jpeg2486https://www.arca.fiocruz.br/bitstream/icict/1918/4/Violacein%20Extracted%20from.pdf.jpgc7c56a9f6484dfb3e7ba9884d4b93001MD54icict/19182018-12-28 16:00:19.424oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-12-28T18:00:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
title Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
spellingShingle Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
Lopes, Stefanie C. P.
Violacein
Chromobacterium Violaceum
Amazon River (Brazil)
Plasmodium Parasites
Research Study
title_short Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
title_full Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
title_fullStr Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
title_full_unstemmed Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
title_sort Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo
author Lopes, Stefanie C. P.
author_facet Lopes, Stefanie C. P.
Blanco, Yara C.
Justo, Giselle Z.
Nogueira, Paulo Afonso
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio T. M.
author_role author
author2 Blanco, Yara C.
Justo, Giselle Z.
Nogueira, Paulo Afonso
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio T. M.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Stefanie C. P.
Blanco, Yara C.
Justo, Giselle Z.
Nogueira, Paulo Afonso
Rodrigues, Francisco L. S.
Goelnitz, Uta
Wunderlich, Gerhard
Facchini, Gustavo
Brocchi, Marcelo
Duran, Nelson
Costa, Fabio T. M.
dc.subject.en.pt_BR.fl_str_mv Violacein
Chromobacterium Violaceum
Amazon River (Brazil)
Plasmodium Parasites
Research Study
topic Violacein
Chromobacterium Violaceum
Amazon River (Brazil)
Plasmodium Parasites
Research Study
description Universidade Estadual de Campinas. Departamento de Microbiologia e Imunologia. Instituto de Biologia. Campinas, SP, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2011-04-15T14:09:18Z
dc.date.available.fl_str_mv 2011-04-15T14:09:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv LOPES, Stefanie C. P. et al. Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo. Antimicrob Agents Chemother. v. 53, n 5, p. 2149-2152, May 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1918
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.doi.pt_BR.fl_str_mv 10.1128/AAC.00693-08
identifier_str_mv LOPES, Stefanie C. P. et al. Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo. Antimicrob Agents Chemother. v. 53, n 5, p. 2149-2152, May 2009.
0066-4804
10.1128/AAC.00693-08
url https://www.arca.fiocruz.br/handle/icict/1918
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