Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.

Detalhes bibliográficos
Autor(a) principal: Fumagalli, Marcilio Jorge
Data de Publicação: 2021
Outros Autores: Castro-Jorge, Luiza Antunes, Fraga-Silva, Thais Fernanda de Campos, de Azevedo, Patrick Orestes, Capato, Carlos Fabiano, Rattis, Bruna Amanda Cruz, Hojo-Souza, Natália Satchiko, Floriano, Vitor Gonçalves, de Castro, Julia Teixeira, Ramos, Simone Gusmão, da Fonseca, Benedito Antônio Lopes, Bonato, Vânia Luiza Deperon, Gazzinelli, Ricardo Tostes, Figueiredo, Luiz Tadeu Moraes.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53562
Resumo: Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil.
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spelling Fumagalli, Marcilio JorgeCastro-Jorge, Luiza AntunesFraga-Silva, Thais Fernanda de Camposde Azevedo, Patrick OrestesCapato, Carlos FabianoRattis, Bruna Amanda CruzHojo-Souza, Natália SatchikoFloriano, Vitor Gonçalvesde Castro, Julia TeixeiraRamos, Simone Gusmãoda Fonseca, Benedito Antônio LopesBonato, Vânia Luiza DeperonGazzinelli, Ricardo TostesFigueiredo, Luiz Tadeu Moraes.2022-06-28T17:52:41Z2022-06-28T17:52:41Z2021FUMAGALLI, Marcilio Jorge et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses ; v. 13, n. 12, 2021, 2440. doi: 10.3390/v131224401999-4915https://www.arca.fiocruz.br/handle/icict/5356210.3390/v13122440engMDPIProtective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleVirology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil.Basic and Applied Immunology Program. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil.Department of Biochemistry and Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Biochemistry and Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil.Department of Pathology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Immunopathology Laboratory. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Immunopathology Laboratory. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Pathology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Basic and Applied Immunology Program. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.Department of Biochemistry and Immunology. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, SP, Brazil.The persistent circulation of SARS-CoV-2 represents an ongoing global threat due to the emergence of new viral variants that can sometimes evade the immune system of previously exposed or vaccinated individuals. We conducted a follow-up study of adult individuals that had received an inactivated SARS-CoV-2 vaccine, evaluating antibody production and neutralizing activity over a period of 6 months. In addition, we performed mice immunization with inactivated SARS-CoV-2, and evaluated the immune response and pathological outcomes against Gamma and Zeta variant infection. Vaccinated individuals produced high levels of antibodies with robust neutralizing activity, which was significantly reduced against Gamma and Zeta variants. Production of IgG anti-S antibodies and neutralizing activity robustly reduced after 6 months of vaccination. Immunized mice demonstrated cellular response against Gamma and Zeta variants, and after viral infection, reduced viral loads, IL-6 expression, and histopathological outcome in the lungs. TNF levels were unchanged in immunized or not immunized mice after infection with the Gamma variant. Furthermore, serum neutralization activity rapidly increases after infection with the Gamma and Zeta variants. Our data suggest that immunization with inactivated WT SARS-CoV-2 induces a promptly responsive cross-reactive immunity response against the Gamma and Zeta variants, reducing COVID-19 pathological outcomes.SARS-CoV-2Gamma variantZeta variantcross-protectioninactivated vaccineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/53562/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALProtective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization - viruses-13-02440.pdfProtective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization - viruses-13-02440.pdfapplication/pdf7270125https://www.arca.fiocruz.br/bitstream/icict/53562/2/Protective%20Immunity%20against%20Gamma%20and%20Zeta%20Variants%20after%20Inactivated%20SARS-CoV-2%20Virus%20Immunization%20-%20viruses-13-02440.pdfe090d29b5c51e6df48703896582bf8ebMD52icict/535622022-06-28 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dc.title.pt_BR.fl_str_mv Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
title Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
spellingShingle Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
Fumagalli, Marcilio Jorge
SARS-CoV-2
Gamma variant
Zeta variant
cross-protection
inactivated vaccine
title_short Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
title_full Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
title_fullStr Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
title_full_unstemmed Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
title_sort Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization.
author Fumagalli, Marcilio Jorge
author_facet Fumagalli, Marcilio Jorge
Castro-Jorge, Luiza Antunes
Fraga-Silva, Thais Fernanda de Campos
de Azevedo, Patrick Orestes
Capato, Carlos Fabiano
Rattis, Bruna Amanda Cruz
Hojo-Souza, Natália Satchiko
Floriano, Vitor Gonçalves
de Castro, Julia Teixeira
Ramos, Simone Gusmão
da Fonseca, Benedito Antônio Lopes
Bonato, Vânia Luiza Deperon
Gazzinelli, Ricardo Tostes
Figueiredo, Luiz Tadeu Moraes.
author_role author
author2 Castro-Jorge, Luiza Antunes
Fraga-Silva, Thais Fernanda de Campos
de Azevedo, Patrick Orestes
Capato, Carlos Fabiano
Rattis, Bruna Amanda Cruz
Hojo-Souza, Natália Satchiko
Floriano, Vitor Gonçalves
de Castro, Julia Teixeira
Ramos, Simone Gusmão
da Fonseca, Benedito Antônio Lopes
Bonato, Vânia Luiza Deperon
Gazzinelli, Ricardo Tostes
Figueiredo, Luiz Tadeu Moraes.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fumagalli, Marcilio Jorge
Castro-Jorge, Luiza Antunes
Fraga-Silva, Thais Fernanda de Campos
de Azevedo, Patrick Orestes
Capato, Carlos Fabiano
Rattis, Bruna Amanda Cruz
Hojo-Souza, Natália Satchiko
Floriano, Vitor Gonçalves
de Castro, Julia Teixeira
Ramos, Simone Gusmão
da Fonseca, Benedito Antônio Lopes
Bonato, Vânia Luiza Deperon
Gazzinelli, Ricardo Tostes
Figueiredo, Luiz Tadeu Moraes.
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
Gamma variant
Zeta variant
cross-protection
inactivated vaccine
topic SARS-CoV-2
Gamma variant
Zeta variant
cross-protection
inactivated vaccine
description Virology Research Center. Ribeirão Preto Medical School. University of São Paulo. Ribeirão Preto, Saulo, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-06-28T17:52:41Z
dc.date.available.fl_str_mv 2022-06-28T17:52:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FUMAGALLI, Marcilio Jorge et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses ; v. 13, n. 12, 2021, 2440. doi: 10.3390/v13122440
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53562
dc.identifier.issn.pt_BR.fl_str_mv 1999-4915
dc.identifier.doi.none.fl_str_mv 10.3390/v13122440
identifier_str_mv FUMAGALLI, Marcilio Jorge et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses ; v. 13, n. 12, 2021, 2440. doi: 10.3390/v13122440
1999-4915
10.3390/v13122440
url https://www.arca.fiocruz.br/handle/icict/53562
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53562/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53562/2/Protective%20Immunity%20against%20Gamma%20and%20Zeta%20Variants%20after%20Inactivated%20SARS-CoV-2%20Virus%20Immunization%20-%20viruses-13-02440.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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