Apoptosis in a canine model of acute Chagasic myocarditis
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15311 |
Resumo: | National Institutes of Health. Pathology Section. National Heart, Lung & Blood Institute. Bethesda, MD, USA |
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Zhang, JAndrade, Zilton de AraújoYu, Z. XAndrade, Sonia GumesTakeda, KSadigursky, MoysésFerrans, V. J2016-08-19T19:19:54Z2016-08-19T19:19:54Z1999ZHANG, J. et al. Apoptosis in a canine model of acute Chagasic myocarditis. Journal of Molecular and Cellular Cardiology, v. 31, p. 581–596, 1999.0022-2828https://www.arca.fiocruz.br/handle/icict/1531110.1006/jmcc.1998.0893engElsevierApoptosis in a canine model of acute Chagasic myocarditisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. Pathology Section. National Heart, Lung & Blood Institute. Bethesda, MD, USAFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFood and Drug Administration. Division of Applied Pharmacology Research. Laurel, MD, USAFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Institutes of Health. Pathology Section. National Heart, Lung & Blood Institute. Bethesda, MD, USAFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFood and Drug Administration. Division of Applied Pharmacology Research. Laurel, MD, USAHistologic, ultrastructural and nick end labeling studies were made to evaluate the occurrence of apoptosis in the hearts of dogs with acute myocarditis due to experimental infection with T. cruzi. The best results for the detection of apoptosis by nick end labeling were obtained by a method combining the use of terminal deoxynucleotidyl transferase, CoCl2 and fluorescein-conjugated deoxyuridine triphosphate, followed by counterstaining of DNA with 4'6-diamidino-2-phenylindole (DAPI) and examination by laser scanning confocal fluorescence microscopy. Apoptosis was found in: (1) cardiac myocytes; (2) endothelial cells of capillaries and venules: (3) immune effector cells, including macrophages, interstitial dendritic cells (antigen-presenting cells) and granular and agranular lymphocytes, and (4) intra- and extracellular forms of T. cruzi. The apoptosis in myocytes and endothelial cells affected cells that were not infected by T. cruzi and was probably caused by the release of toxic mediators of inflammation. The apoptosis of immune effector cells could be related either to the subsidence of inflammation or to modulation (and even failure) of the immune response. The finding of apoptosis in T. cruzi confirms the results of other studies showing that this phenomenon occurs during the differentiation of trypomastigotes in vitro. Thus, apoptosis constitutes an important and multifactorial event in the pathogenesis of acute Chagasic myocarditis.Trypanosoma cruziApoptosisAcute myocarditisDogNick end labelingElectron microscopyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15311/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALZhang Jun Apoptosis in a canine....pdfZhang Jun Apoptosis in a canine....pdfapplication/pdf9995087https://www.arca.fiocruz.br/bitstream/icict/15311/2/Zhang%20Jun%20Apoptosis%20in%20a%20canine....pdf597688527ab2449402b5cff7f1ab09f6MD52TEXTZhang Jun Apoptosis in a canine....pdf.txtZhang Jun Apoptosis in a canine....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Apoptosis in a canine model of acute Chagasic myocarditis |
title |
Apoptosis in a canine model of acute Chagasic myocarditis |
spellingShingle |
Apoptosis in a canine model of acute Chagasic myocarditis Zhang, J Trypanosoma cruzi Apoptosis Acute myocarditis Dog Nick end labeling Electron microscopy |
title_short |
Apoptosis in a canine model of acute Chagasic myocarditis |
title_full |
Apoptosis in a canine model of acute Chagasic myocarditis |
title_fullStr |
Apoptosis in a canine model of acute Chagasic myocarditis |
title_full_unstemmed |
Apoptosis in a canine model of acute Chagasic myocarditis |
title_sort |
Apoptosis in a canine model of acute Chagasic myocarditis |
author |
Zhang, J |
author_facet |
Zhang, J Andrade, Zilton de Araújo Yu, Z. X Andrade, Sonia Gumes Takeda, K Sadigursky, Moysés Ferrans, V. J |
author_role |
author |
author2 |
Andrade, Zilton de Araújo Yu, Z. X Andrade, Sonia Gumes Takeda, K Sadigursky, Moysés Ferrans, V. J |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Zhang, J Andrade, Zilton de Araújo Yu, Z. X Andrade, Sonia Gumes Takeda, K Sadigursky, Moysés Ferrans, V. J |
dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Apoptosis Acute myocarditis Dog Nick end labeling Electron microscopy |
topic |
Trypanosoma cruzi Apoptosis Acute myocarditis Dog Nick end labeling Electron microscopy |
description |
National Institutes of Health. Pathology Section. National Heart, Lung & Blood Institute. Bethesda, MD, USA |
publishDate |
1999 |
dc.date.issued.fl_str_mv |
1999 |
dc.date.accessioned.fl_str_mv |
2016-08-19T19:19:54Z |
dc.date.available.fl_str_mv |
2016-08-19T19:19:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ZHANG, J. et al. Apoptosis in a canine model of acute Chagasic myocarditis. Journal of Molecular and Cellular Cardiology, v. 31, p. 581–596, 1999. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15311 |
dc.identifier.issn.pt_BR.fl_str_mv |
0022-2828 |
dc.identifier.doi.none.fl_str_mv |
10.1006/jmcc.1998.0893 |
identifier_str_mv |
ZHANG, J. et al. Apoptosis in a canine model of acute Chagasic myocarditis. Journal of Molecular and Cellular Cardiology, v. 31, p. 581–596, 1999. 0022-2828 10.1006/jmcc.1998.0893 |
url |
https://www.arca.fiocruz.br/handle/icict/15311 |
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eng |
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eng |
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openAccess |
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Elsevier |
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Elsevier |
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