Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings

Detalhes bibliográficos
Autor(a) principal: McMurry, Timothy L.
Data de Publicação: 2020
Outros Autores: McQuade, Elizabeth T. Rogawski, Liu, Jie, Kang, Gagandeep, Kosek, Margaret N., LIma, Aldo A. M., Bessong, Pascal O., Samie, Amidou, Haque, Rashidul, Mduma, Estomih R., Leite, José Paulo G., Bodhidatta, Ladaporn, Iqbal, Najeeha T., Page, Nicola, Kiwelu, Ireen, Bhutta, Zulfiqar A., Ahmed, Tahmeed, Houpt, Eric R., Platts-Mills, James A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45672
Resumo: Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA,
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spelling McMurry, Timothy L.McQuade, Elizabeth T. RogawskiLiu, JieKang, GagandeepKosek, Margaret N.LIma, Aldo A. M.Bessong, Pascal O.Samie, AmidouHaque, RashidulMduma, Estomih R.Leite, José Paulo G.Bodhidatta, LadapornIqbal, Najeeha T.Page, NicolaKiwelu, IreenBhutta, Zulfiqar A.Ahmed, TahmeedHoupt, Eric R.Platts-Mills, James A.2021-01-13T19:12:13Z2021-01-13T19:12:13Z2020McMURRY, Thimothy L. et al. Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings. Clinical Infectious Diseases, XX(XX), p.1–9, 2020.1537-6591https://www.arca.fiocruz.br/handle/icict/4567210.1093/cid/ciaa15281058-4838engOxford University PressDiarréiaCriançasPeríodo de incubaçãoDerramamentoAsymptomatic DiseasesDiarrheaAsymptomatic carriageIncubation periodChildrenSheddingDuration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settingsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA,Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA / Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia. USA.Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia. USA.Christian Medical College. Vellore, India.Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia. USA / Asociación Benéfica PRISMA. Iquitos, Peru.Universidade Federal do Ceará. Fortaleza, CE, Brasil.University of Venda. Thohoyandou, South Africa.University of Venda. Thohoyandou, South Africa.International Centre for Diarrhoeal Disease Research. Bangladesh, Dhaka, Bangladesh.8Haydom Global Health Research Centre. Haydom, Tanzania.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Armed Forces Research Institute of Medical Sciences. Bangkok, Thailand.Aga Khan University. Karachi, Pakistan.National Institute for Communicable Diseases. Johannesburg, South Africa.Kilimanjaro Clinical Research Institute. Moshi, Tanzania.Aga Khan University. Karachi, Pakistan.International Centre for Diarrhoeal Disease Research. Bangladesh, Dhaka, Bangladesh.Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia. USA.Division of Infectious Diseases and International Health, University of Virginia. Charlottesville, Virginia. USA.Background. Prolonged enteropathogen shedding after diarrhea complicates the identification of etiology in subsequent episodes and is an important driver of pathogen transmission. A standardized approach has not been applied to estimate the duration of shedding for a wide range of pathogens. Methods. We used a multisite birth cohort of children 0–24 months of age from whom diarrheal and monthly nondiarrheal stools were previously tested by quantitative polymerase chain reaction for 29 enteropathogens. We modeled the probability of detection of the etiologic pathogen before and after diarrhea using a log-normal accelerated failure time survival model and estimated the median duration of pathogen carriage as well as differences in subclinical pathogen carriage 60 days after diarrhea onset in comparison to a prediarrhea baseline. Results. We analyzed 3247 etiologic episodes of diarrhea for the 9 pathogens with the highest attributable burdens of diarrhea. The median duration of postdiarrheal carriage varied widely by pathogen, from about 1 week for rotavirus (median, 8.1 days [95% confidence interval {CI}, 6.2–9.6]) to >1 month for Cryptosporidium (39.5 days [95% CI, 30.6–49.0]). The largest increases in subclinical pathogen carriage before and after diarrhea were seen for Cryptosporidium (prevalence difference between 30 days prior and 60 days after diarrhea onset, 0.30 [95% CI, .23–.39]) and Shigella (prevalence difference, 0.21 [95% CI, .16–.27]). Conclusions. Postdiarrheal shedding was widely variable between pathogens, with strikingly prolonged shedding seen for Cryptosporidium and Shigella. Targeted antimicrobial therapy and vaccination for these pathogens may have a relatively large impact on transmission.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45672/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJosePauloG_Leite_etal_IOC_2020.pdfJosePauloG_Leite_etal_IOC_2020.pdfapplication/pdf1293289https://www.arca.fiocruz.br/bitstream/icict/45672/2/JosePauloG_Leite_etal_IOC_2020.pdfce5251112b39aaec67d4ca57931ce56cMD52TEXTJosePauloG_Leite_etal_IOC_2020.pdf.txtJosePauloG_Leite_etal_IOC_2020.pdf.txtExtracted texttext/plain43996https://www.arca.fiocruz.br/bitstream/icict/45672/3/JosePauloG_Leite_etal_IOC_2020.pdf.txt141b9be5d354baac4093c0f005bfe35fMD53icict/456722021-01-14 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dc.title.pt_BR.fl_str_mv Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
title Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
spellingShingle Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
McMurry, Timothy L.
Diarréia
Crianças
Período de incubação
Derramamento
Asymptomatic Diseases
Diarrhea
Asymptomatic carriage
Incubation period
Children
Shedding
title_short Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
title_full Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
title_fullStr Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
title_full_unstemmed Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
title_sort Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings
author McMurry, Timothy L.
author_facet McMurry, Timothy L.
McQuade, Elizabeth T. Rogawski
Liu, Jie
Kang, Gagandeep
Kosek, Margaret N.
LIma, Aldo A. M.
Bessong, Pascal O.
Samie, Amidou
Haque, Rashidul
Mduma, Estomih R.
Leite, José Paulo G.
Bodhidatta, Ladaporn
Iqbal, Najeeha T.
Page, Nicola
Kiwelu, Ireen
Bhutta, Zulfiqar A.
Ahmed, Tahmeed
Houpt, Eric R.
Platts-Mills, James A.
author_role author
author2 McQuade, Elizabeth T. Rogawski
Liu, Jie
Kang, Gagandeep
Kosek, Margaret N.
LIma, Aldo A. M.
Bessong, Pascal O.
Samie, Amidou
Haque, Rashidul
Mduma, Estomih R.
Leite, José Paulo G.
Bodhidatta, Ladaporn
Iqbal, Najeeha T.
Page, Nicola
Kiwelu, Ireen
Bhutta, Zulfiqar A.
Ahmed, Tahmeed
Houpt, Eric R.
Platts-Mills, James A.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv McMurry, Timothy L.
McQuade, Elizabeth T. Rogawski
Liu, Jie
Kang, Gagandeep
Kosek, Margaret N.
LIma, Aldo A. M.
Bessong, Pascal O.
Samie, Amidou
Haque, Rashidul
Mduma, Estomih R.
Leite, José Paulo G.
Bodhidatta, Ladaporn
Iqbal, Najeeha T.
Page, Nicola
Kiwelu, Ireen
Bhutta, Zulfiqar A.
Ahmed, Tahmeed
Houpt, Eric R.
Platts-Mills, James A.
dc.subject.other.pt_BR.fl_str_mv Diarréia
Crianças
Período de incubação
Derramamento
Asymptomatic Diseases
topic Diarréia
Crianças
Período de incubação
Derramamento
Asymptomatic Diseases
Diarrhea
Asymptomatic carriage
Incubation period
Children
Shedding
dc.subject.en.pt_BR.fl_str_mv Diarrhea
Asymptomatic carriage
Incubation period
Children
Shedding
description Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA,
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-13T19:12:13Z
dc.date.available.fl_str_mv 2021-01-13T19:12:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv McMURRY, Thimothy L. et al. Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings. Clinical Infectious Diseases, XX(XX), p.1–9, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45672
dc.identifier.issn.pt_BR.fl_str_mv 1537-6591
dc.identifier.doi.none.fl_str_mv 10.1093/cid/ciaa1528
dc.identifier.eissn.none.fl_str_mv 1058-4838
identifier_str_mv McMURRY, Thimothy L. et al. Duration of Postdiarrheal Enteric Pathogen Carriage in Young Children in Low-resource Settings. Clinical Infectious Diseases, XX(XX), p.1–9, 2020.
1537-6591
10.1093/cid/ciaa1528
1058-4838
url https://www.arca.fiocruz.br/handle/icict/45672
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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