Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26872 |
Resumo: | Moreira, Diogo Rodrigo de Magalhães. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. A. C. L. Leite (&) F. F. Barbosa M. V. O. Cardoso D. R. M. Moreira L. C. D. Coêlho E. B. da Silva G. B. O. Filho V. M. O. de Souza Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil e-mail: acllb2003@yahoo.com.br V. R. A. Pereira L. de C. Reis Departamento de Imunologia, Centro de Pesquisas Ageu Magalhães-FIOCRUZ, Recife, PE, Brazil P. M. P. Ferreira Departamento de Ciências Biológicas, Universidade Federal do Piauí, Picos, Piauí 64607-670, Brazil C. Pessoa Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal do Ceará, Fortaleza, CE 60430-270, Brazil A. G. Wanderley Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil F. V. B. Mota T. G. da Silva Departamento de Antibio´ticos, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil |
| id |
CRUZ_c3588712710a87dd368aa6d94d325568 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/26872 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Leite, Ana Cristina LimaBarbosa, Fábio FernandesCardoso, Marcos Veríssimo de OliveiraMoreira, Diogo Rodrigo de MagalhãesCoêlho, Lucas Cunha DuarteSilva, Elany Barbosa daOliveira Filho, Gevanio Bezerra deSouza, Valdênia Maria Oliveira dePereira, Valéria Rêgo AReis, Luiza de CamposFerreira, Paulo Michel PinheiroPessoa, ClaudiaWanderley, Almir GonçalvesMota, Fernanda Virgínia BarretoSilva, Teresinha Gonçalves da2018-06-13T16:30:02Z2018-06-13T16:30:02Z2014LEITE, A. C. L. et al. Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes. Medicinal Chemistry Research, v. 23, p. 1701–1708, 2014.1054-2523https://www.arca.fiocruz.br/handle/icict/26872Moreira, Diogo Rodrigo de Magalhães. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. A. C. L. Leite (&) F. F. Barbosa M. V. O. Cardoso D. R. M. Moreira L. C. D. Coêlho E. B. da Silva G. B. O. Filho V. M. O. de Souza Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil e-mail: acllb2003@yahoo.com.br V. R. A. Pereira L. de C. Reis Departamento de Imunologia, Centro de Pesquisas Ageu Magalhães-FIOCRUZ, Recife, PE, Brazil P. M. P. Ferreira Departamento de Ciências Biológicas, Universidade Federal do Piauí, Picos, Piauí 64607-670, Brazil C. Pessoa Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal do Ceará, Fortaleza, CE 60430-270, Brazil A. G. Wanderley Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil F. V. B. Mota T. G. da Silva Departamento de Antibio´ticos, Universidade Federal de Pernambuco, Recife, PE 50740-520, BrazilBrazilian National Research Council (CNPq), FACEPE, and FIOCRUZMúltipla – ver em NotasAbstract A series of phthalimide analogs were synthesized by derivatization of phthalic anhydride, a highly toxic substance, using a ‘‘one pot’’ condensation reaction to a-amino acids. All phthaloyl amino acid derivatives presented anti-oral inflammatory activity, but compounds 2e and 2g were found to possess the best activities comparable to thalidomide.Most of the compounds effectively suppressed nitric oxide production inmurine cells stimulatedwith lipopolysaccharide.Nphthaloyl amino acids did not exhibit any significant cytotoxicity in vitro when tested against tumor cells as well as a spleen cell culture of BALB/c mice. Compounds 2a, 2g, and 2h were able to inhibit TNF-a and IL-1b production by macrophages. At the same concentration, thalidomide did not exhibit significant inhibitory activity.engSpringer VerlagN-ftaloil aminoácidosAnti-inflamatórioImunomoduladorN-phthaloyl amino acidsAnti-inflammatoryImmunomodulatoryPhthaloyl amino acids as anti-inflammatory and immunomodulatory prototypesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26872/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLeite ACL Phthaloyl amino....pdfLeite ACL Phthaloyl amino....pdfapplication/pdf345295https://www.arca.fiocruz.br/bitstream/icict/26872/2/Leite%20ACL%20Phthaloyl%20amino....pdf14d3393083d9e023a78131372f340adeMD52TEXTLeite ACL Phthaloyl amino....pdf.txtLeite ACL Phthaloyl amino....pdf.txtExtracted texttext/plain35099https://www.arca.fiocruz.br/bitstream/icict/26872/3/Leite%20ACL%20Phthaloyl%20amino....pdf.txt138f250ba58a3409e80abed50108933eMD53icict/268722023-03-15 14:34:12.533oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| title |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| spellingShingle |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes Leite, Ana Cristina Lima N-ftaloil aminoácidos Anti-inflamatório Imunomodulador N-phthaloyl amino acids Anti-inflammatory Immunomodulatory |
| title_short |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| title_full |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| title_fullStr |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| title_full_unstemmed |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| title_sort |
Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes |
| author |
Leite, Ana Cristina Lima |
| author_facet |
Leite, Ana Cristina Lima Barbosa, Fábio Fernandes Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo de Magalhães Coêlho, Lucas Cunha Duarte Silva, Elany Barbosa da Oliveira Filho, Gevanio Bezerra de Souza, Valdênia Maria Oliveira de Pereira, Valéria Rêgo A Reis, Luiza de Campos Ferreira, Paulo Michel Pinheiro Pessoa, Claudia Wanderley, Almir Gonçalves Mota, Fernanda Virgínia Barreto Silva, Teresinha Gonçalves da |
| author_role |
author |
| author2 |
Barbosa, Fábio Fernandes Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo de Magalhães Coêlho, Lucas Cunha Duarte Silva, Elany Barbosa da Oliveira Filho, Gevanio Bezerra de Souza, Valdênia Maria Oliveira de Pereira, Valéria Rêgo A Reis, Luiza de Campos Ferreira, Paulo Michel Pinheiro Pessoa, Claudia Wanderley, Almir Gonçalves Mota, Fernanda Virgínia Barreto Silva, Teresinha Gonçalves da |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Leite, Ana Cristina Lima Barbosa, Fábio Fernandes Cardoso, Marcos Veríssimo de Oliveira Moreira, Diogo Rodrigo de Magalhães Coêlho, Lucas Cunha Duarte Silva, Elany Barbosa da Oliveira Filho, Gevanio Bezerra de Souza, Valdênia Maria Oliveira de Pereira, Valéria Rêgo A Reis, Luiza de Campos Ferreira, Paulo Michel Pinheiro Pessoa, Claudia Wanderley, Almir Gonçalves Mota, Fernanda Virgínia Barreto Silva, Teresinha Gonçalves da |
| dc.subject.other.pt_BR.fl_str_mv |
N-ftaloil aminoácidos Anti-inflamatório Imunomodulador |
| topic |
N-ftaloil aminoácidos Anti-inflamatório Imunomodulador N-phthaloyl amino acids Anti-inflammatory Immunomodulatory |
| dc.subject.en.pt_BR.fl_str_mv |
N-phthaloyl amino acids Anti-inflammatory Immunomodulatory |
| description |
Moreira, Diogo Rodrigo de Magalhães. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. A. C. L. Leite (&) F. F. Barbosa M. V. O. Cardoso D. R. M. Moreira L. C. D. Coêlho E. B. da Silva G. B. O. Filho V. M. O. de Souza Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil e-mail: acllb2003@yahoo.com.br V. R. A. Pereira L. de C. Reis Departamento de Imunologia, Centro de Pesquisas Ageu Magalhães-FIOCRUZ, Recife, PE, Brazil P. M. P. Ferreira Departamento de Ciências Biológicas, Universidade Federal do Piauí, Picos, Piauí 64607-670, Brazil C. Pessoa Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal do Ceará, Fortaleza, CE 60430-270, Brazil A. G. Wanderley Departamento de Fisiologia e Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil F. V. B. Mota T. G. da Silva Departamento de Antibio´ticos, Universidade Federal de Pernambuco, Recife, PE 50740-520, Brazil |
| publishDate |
2014 |
| dc.date.issued.fl_str_mv |
2014 |
| dc.date.accessioned.fl_str_mv |
2018-06-13T16:30:02Z |
| dc.date.available.fl_str_mv |
2018-06-13T16:30:02Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
LEITE, A. C. L. et al. Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes. Medicinal Chemistry Research, v. 23, p. 1701–1708, 2014. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26872 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1054-2523 |
| identifier_str_mv |
LEITE, A. C. L. et al. Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes. Medicinal Chemistry Research, v. 23, p. 1701–1708, 2014. 1054-2523 |
| url |
https://www.arca.fiocruz.br/handle/icict/26872 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Springer Verlag |
| publisher.none.fl_str_mv |
Springer Verlag |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/26872/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/26872/2/Leite%20ACL%20Phthaloyl%20amino....pdf https://www.arca.fiocruz.br/bitstream/icict/26872/3/Leite%20ACL%20Phthaloyl%20amino....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 14d3393083d9e023a78131372f340ade 138f250ba58a3409e80abed50108933e |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008972179832832 |