A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS

Detalhes bibliográficos
Autor(a) principal: Faria Neto, Hugo Caire C.
Data de Publicação: 1997
Outros Autores: Penido, Carmen M., Larangeira, Andréa P., Silva, Adriana R., Bozza, Patrícia T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43908
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling Faria Neto, Hugo Caire C.Penido, Carmen M.Larangeira, Andréa P.Silva, Adriana R.Bozza, Patrícia T.2020-10-09T18:02:23Z2020-10-09T18:02:23Z1997FARIA NETO, Hugo C. Castro et al. A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 197-200, 1997.0074-0276https://www.arca.fiocruz.br/handle/icict/4390810.1590/S0074-027619970008000261678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.LPSCélulas TMacrófagosEosinófilosCitocinasLPSEosinophilMacrophagesT-cellsCytokinesA Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPSinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.In the present work we review the existing evidence for a LPS-induced cytokine-mediated eosinophil accumulation in a model of acute inflammation. Intrathoracic administration of LPS into rodents (mice, rats or guinea pigs) induces a significant increase in the number of eosinophils recovered from the pleural fluid 24 hr later. This phenomenon is preceded by a neutrophil influx and accompanied by lymphocyte and monocyte accumulation. The eosinophil accumulation induced by LPS is not affected by inhibitors of cyclo or lipoxygenase nor by PAF antagonists but can be blocked by dexamethasone or the protein synthesis inhibitor cycloheximide. Transfer of cell-free pleural wash from LPS injected rats (LPS-PW) to naive recipient animals induces a selective eosinophil accumulation within 24 hr. The eosinophilotactic activity present on the LPS-PW has a molecular weight ranging between 10 and 50 kDa and its effect is abolished by trypsin digestion of the pleural wash indicating the proteic nature of this activity. The production of the eosinophilotactic activity depends on the interaction between macrophages and T-lymphocytes and its effect can not be blocked by anti-IL-5 monoclonal antibodies. Accumulated evidence suggest that the eosinophil accumulation induced by LPS is a consequence of a eosinophilotactic cytokine produced through macrophage and T-cell interactions in the site of a LPS-induced inflammatory reaction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43908/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHugoCastro_FariaNeto_etal_IOC_1997.pdfHugoCastro_FariaNeto_etal_IOC_1997.pdfapplication/pdf79178https://www.arca.fiocruz.br/bitstream/icict/43908/2/HugoCastro_FariaNeto_etal_IOC_1997.pdfb6b49aceaaaefff10d28e153180f5cedMD52TEXTHugoCastro_FariaNeto_etal_IOC_1997.pdf.txtHugoCastro_FariaNeto_etal_IOC_1997.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
title A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
spellingShingle A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
Faria Neto, Hugo Caire C.
LPS
Células T
Macrófagos
Eosinófilos
Citocinas
LPS
Eosinophil
Macrophages
T-cells
Cytokines
title_short A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
title_full A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
title_fullStr A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
title_full_unstemmed A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
title_sort A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS
author Faria Neto, Hugo Caire C.
author_facet Faria Neto, Hugo Caire C.
Penido, Carmen M.
Larangeira, Andréa P.
Silva, Adriana R.
Bozza, Patrícia T.
author_role author
author2 Penido, Carmen M.
Larangeira, Andréa P.
Silva, Adriana R.
Bozza, Patrícia T.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Faria Neto, Hugo Caire C.
Penido, Carmen M.
Larangeira, Andréa P.
Silva, Adriana R.
Bozza, Patrícia T.
dc.subject.other.pt_BR.fl_str_mv LPS
Células T
Macrófagos
Eosinófilos
Citocinas
topic LPS
Células T
Macrófagos
Eosinófilos
Citocinas
LPS
Eosinophil
Macrophages
T-cells
Cytokines
dc.subject.en.pt_BR.fl_str_mv LPS
Eosinophil
Macrophages
T-cells
Cytokines
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Núcleo de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2020-10-09T18:02:23Z
dc.date.available.fl_str_mv 2020-10-09T18:02:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FARIA NETO, Hugo C. Castro et al. A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 197-200, 1997.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43908
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761997000800026
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv FARIA NETO, Hugo C. Castro et al. A Role for Lymphocytes and Cytokines on the Eosinophil Migration Induced by LPS. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 92, Suppl. 2, p. 197-200, 1997.
0074-0276
10.1590/S0074-02761997000800026
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43908
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/43908/2/HugoCastro_FariaNeto_etal_IOC_1997.pdf
https://www.arca.fiocruz.br/bitstream/icict/43908/3/HugoCastro_FariaNeto_etal_IOC_1997.pdf.txt
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