Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators

Detalhes bibliográficos
Autor(a) principal: Azeredo, Elzinandes Leal de
Data de Publicação: 2015
Outros Autores: Monteiro, Robson Q., Pinto, Luzia Maria de-Oliveira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14394
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
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spelling Azeredo, Elzinandes Leal deMonteiro, Robson Q.Pinto, Luzia Maria de-Oliveira2016-05-19T15:00:16Z2016-05-19T15:00:16Z2015AZEREDO, Elzinandes Leal de; MONTEIRO, Robson Q.; OLIVEIRA PINTO, Luzia Maria de. Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Mediators of Inflammation, v. 2015, Article ID 313842, 16p, 2015.0962-9351https://www.arca.fiocruz.br/handle/icict/1439410.1155/2015/3138421466-1861engHindawi Publishing CorporationThrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediatorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquimica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Dengue is an infectious disease caused by dengue virus (DENV). In general, dengue is a self-limiting acute febrile illness followed by a phase of critical defervescence, in which patients may improve or progress to a severe form. Severe illness is characterized by hemodynamic disturbances, increased vascular permeability, hypovolemia, hypotension, and shock. Thrombocytopenia and platelet dysfunction are common in both cases and are related to the clinical outcome. Different mechanisms have been hypothesized to explain DENV-associated thrombocytopenia, including the suppression of bone marrow and the peripheral destruction of platelets. Studies have shown DENV-infected hematopoietic progenitors or bone marrow stromal cells. Moreover, anti-platelet antibodies would be involved in peripheral platelet destruction as platelets interact with endothelial cells, immune cells, and/or DENV. It is not yet clear whether platelets play a role in the viral spread. Here, we focus on the mechanisms of thrombocytopenia and platelet dysfunction in DENV infection. Because platelets participate in the inflammatory and immune response by promoting cytokine, chemokine, and inflammatory mediator secretion, their relevance as “immune-like effector cells” will be discussed. Finally, an implication for platelets in plasma leakage will be also regarded, as thrombocytopenia is associated with clinical outcome and higher mortality.DengueThrombocytopeniaFibrinolysisInflammatory MediatorsPlatelet dysfunctionDengueTrombocitopeniaFibrinóliseInfecçãoPlaquetasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14394/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALelzinandes_azeredo_etal_IOC_2015.pdfelzinandes_azeredo_etal_IOC_2015.pdfapplication/pdf1722812https://www.arca.fiocruz.br/bitstream/icict/14394/2/elzinandes_azeredo_etal_IOC_2015.pdf4c77e87858819543c4c48b2f10d776b1MD52TEXTelzinandes_azeredo_etal_IOC_2015.pdf.txtelzinandes_azeredo_etal_IOC_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
title Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
spellingShingle Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
Azeredo, Elzinandes Leal de
Dengue
Thrombocytopenia
Fibrinolysis
Inflammatory Mediators
Platelet dysfunction
Dengue
Trombocitopenia
Fibrinólise
Infecção
Plaquetas
title_short Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
title_full Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
title_fullStr Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
title_full_unstemmed Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
title_sort Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators
author Azeredo, Elzinandes Leal de
author_facet Azeredo, Elzinandes Leal de
Monteiro, Robson Q.
Pinto, Luzia Maria de-Oliveira
author_role author
author2 Monteiro, Robson Q.
Pinto, Luzia Maria de-Oliveira
author2_role author
author
dc.contributor.author.fl_str_mv Azeredo, Elzinandes Leal de
Monteiro, Robson Q.
Pinto, Luzia Maria de-Oliveira
dc.subject.en.pt_BR.fl_str_mv Dengue
Thrombocytopenia
Fibrinolysis
Inflammatory Mediators
Platelet dysfunction
topic Dengue
Thrombocytopenia
Fibrinolysis
Inflammatory Mediators
Platelet dysfunction
Dengue
Trombocitopenia
Fibrinólise
Infecção
Plaquetas
dc.subject.decs.pt_BR.fl_str_mv Dengue
Trombocitopenia
Fibrinólise
Infecção
Plaquetas
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-05-19T15:00:16Z
dc.date.available.fl_str_mv 2016-05-19T15:00:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv AZEREDO, Elzinandes Leal de; MONTEIRO, Robson Q.; OLIVEIRA PINTO, Luzia Maria de. Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Mediators of Inflammation, v. 2015, Article ID 313842, 16p, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14394
dc.identifier.issn.none.fl_str_mv 0962-9351
dc.identifier.doi.none.fl_str_mv 10.1155/2015/313842
dc.identifier.eissn.none.fl_str_mv 1466-1861
identifier_str_mv AZEREDO, Elzinandes Leal de; MONTEIRO, Robson Q.; OLIVEIRA PINTO, Luzia Maria de. Thrombocytopenia in Dengue: Interrelationship between Virus and the Imbalance between Coagulation and Fibrinolysis and Inflammatory Mediators. Mediators of Inflammation, v. 2015, Article ID 313842, 16p, 2015.
0962-9351
10.1155/2015/313842
1466-1861
url https://www.arca.fiocruz.br/handle/icict/14394
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/14394/2/elzinandes_azeredo_etal_IOC_2015.pdf
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