Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14014 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil. |
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Oliveira, E. R. A.Amorim, J. F. SPaes, M. V.Azevedo, A. S.Gonçalves, A. J. S.Costa, S. M.Mantuano-Barradas, M.Póvoa, T. F.Meis, J.Oliveira, C. A. Basílio deNogueira, A. C. M. A.Alves, A. M. B.2016-04-28T15:45:33Z2016-04-28T15:45:33Z2016OLIVEIRA, E. R. A. et al. Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route. Virology, v.489, p.95-107, Feb. 2016.0042-6822https://www.arca.fiocruz.br/handle/icict/1401410.1016/j.virol.2015.12.006engElsevierDengueSistema Nervoso CentralResposta ImuneInfecção intracerebralCamundongosDengueMouse modelIntracerebral infectionImmune responseCentral nervous systemPeripheral effects induced in BALB/c mice infected with DENV by the intracerebral routeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Hospital Gaffrée Guinle. Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil.The lack of an immunocompetent animal model for dengue mimicking the disease in humans is a limitation for advances in this field. Inoculation by intracerebral route of neuroadapted dengue strains in mice is normally lethal and provides a straightforward readout parameter for vaccine testing. However, systemic effects of infection and the immune response elicited in this model remain poorly described. In the present work, BALB/c mice infected by the intracerebral route with neuroadapted DENV2 exhibited several evidences of systemic involvement. DENV-inoculated mice presented virus infective particles in the brain followed by viremia, especially in late stages of infection. Infection induced cellular and humoral responses, with presence of activated T cells in spleen and blood, lymphocyte infiltration and tissue damages in brain and liver, and an increase in serum levels of some pro-inflammatory cytokines. Data highlighted an interplay between the central nervous system commitment and peripheral effects under this experimental condition.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14014/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALajs_gonçalves_etal_IOC_2016.pdfajs_gonçalves_etal_IOC_2016.pdfapplication/pdf4716712https://www.arca.fiocruz.br/bitstream/icict/14014/2/ajs_gon%c3%a7alves_etal_IOC_2016.pdfe6769839da19872ac067869a2793fe03MD52TEXTajs_gonçalves_etal_IOC_2016.pdf.txtajs_gonçalves_etal_IOC_2016.pdf.txtExtracted texttext/plain64407https://www.arca.fiocruz.br/bitstream/icict/14014/3/ajs_gon%c3%a7alves_etal_IOC_2016.pdf.txt3e6ccc233297656255054d4ba5fac604MD53icict/140142018-04-02 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| dc.title.pt_BR.fl_str_mv |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| title |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| spellingShingle |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route Oliveira, E. R. A. Dengue Sistema Nervoso Central Resposta Imune Infecção intracerebral Camundongos Dengue Mouse model Intracerebral infection Immune response Central nervous system |
| title_short |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| title_full |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| title_fullStr |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| title_full_unstemmed |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| title_sort |
Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route |
| author |
Oliveira, E. R. A. |
| author_facet |
Oliveira, E. R. A. Amorim, J. F. S Paes, M. V. Azevedo, A. S. Gonçalves, A. J. S. Costa, S. M. Mantuano-Barradas, M. Póvoa, T. F. Meis, J. Oliveira, C. A. Basílio de Nogueira, A. C. M. A. Alves, A. M. B. |
| author_role |
author |
| author2 |
Amorim, J. F. S Paes, M. V. Azevedo, A. S. Gonçalves, A. J. S. Costa, S. M. Mantuano-Barradas, M. Póvoa, T. F. Meis, J. Oliveira, C. A. Basílio de Nogueira, A. C. M. A. Alves, A. M. B. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, E. R. A. Amorim, J. F. S Paes, M. V. Azevedo, A. S. Gonçalves, A. J. S. Costa, S. M. Mantuano-Barradas, M. Póvoa, T. F. Meis, J. Oliveira, C. A. Basílio de Nogueira, A. C. M. A. Alves, A. M. B. |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Sistema Nervoso Central Resposta Imune Infecção intracerebral Camundongos |
| topic |
Dengue Sistema Nervoso Central Resposta Imune Infecção intracerebral Camundongos Dengue Mouse model Intracerebral infection Immune response Central nervous system |
| dc.subject.en.pt_BR.fl_str_mv |
Dengue Mouse model Intracerebral infection Immune response Central nervous system |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biotecnologia e Fisiologia de Infecções Virais. Rio de Janeiro, RJ, Brasil. |
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2016 |
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2016-04-28T15:45:33Z |
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2016-04-28T15:45:33Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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OLIVEIRA, E. R. A. et al. Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route. Virology, v.489, p.95-107, Feb. 2016. |
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https://www.arca.fiocruz.br/handle/icict/14014 |
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0042-6822 |
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10.1016/j.virol.2015.12.006 |
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OLIVEIRA, E. R. A. et al. Peripheral effects induced in BALB/c mice infected with DENV by the intracerebral route. Virology, v.489, p.95-107, Feb. 2016. 0042-6822 10.1016/j.virol.2015.12.006 |
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