Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/12381 |
Resumo: | Hospital Femina. Unidade de Prevenção à Transmissão Vertical. Porto Alegre, RS, Brasil. |
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Peixoto, Mario FerreiraPilotto, José HenriqueStoszek, Sonia KarolinaKreitchmann, RegisPinhata, Marisa Márcia MussiMelo, Victor HugoJoão, Esaú CustodioCeriotto, MarianaSouza, Ricardo da Silva deRead, Jennifer2015-12-10T14:49:37Z2015-12-10T14:49:37Z2011PEIXOTO, Mario Ferreira; et al. Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities. Braz J Infect Dis., v.15, n.3, May/June 2011.1413-8670https://www.arca.fiocruz.br/handle/icict/1238110.1590/S1413-86702011000300013engBrazilian Society of Infectious DiseasesGravidezInibidores da Protease HIVHIVToxicidadeLopinavirRitonavirPregnancyHIVHIV protease inhibitorsDrug toxicityLopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalitiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHospital Femina. Unidade de Prevenção à Transmissão Vertical. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / Hospital Geral de Nova Iguaçu. Nova Iguaçu, RJ, Brasil.Westat. Rockville, Maryland, USA.Irmandade da Santa Casa de Misericórdia de Porto Alegre. Porto Alegre, RS, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal de Minas Gerais. Belo Horizonte, MG, Brasil.Hospital dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Hospital de Agudos Dra. Cecilia Grierson. Buenos Aires, Argentina.Universidade de Caxias do Sul. STD/HIV Clinic. Rio Grande do Sul, RS, Brasil.CRMC-NICHD-NIH. Pediatric, Adolescent, and Maternal AIDS Branch. Bethesda, Maryland, USA.OBJECTIVES: To describe laboratory abnormalities among HIV-infected women and their infants with standard and increased lopinavir/ritonavir (LPV/r) dosing during the third trimester of pregnancy. METHODS: We evaluated data on pregnant women from NISDI cohorts (2002-2009) enrolled in Brazil, who received at least 28 days of LPV/r during the third pregnancy trimester and gave birth to singleton infants. RESULTS: 164 women received LPV/r standard dosing [(798/198 or 800/200 mg/day) (Group 1)] and 70 increased dosing [(> 800/200 mg/day) (Group 2)]. Group 1 was more likely to have advanced clinical disease and to use ARVs for treatment, and less likely to have CD4 counts > 500 cells/mm3. Mean plasma viral load was higher in Group 2. There were statistically significant, but not clinically meaningful, differences between groups in mean AST, ALT, cholesterol, and triglycerides. The proportion of women with Grade 3 or 4 adverse events was very low, with no statistically significant differences between groups in severe adverse events related to ALT, AST, total bilirubin, cholesterol, or triglycerides. There were statistically significant, but not clinically meaningful, differences between infant groups in ALT and creatinine. The proportion of infants with Grade 3 or 4 adverse events was very low, and there were no statistically significant differences in severe adverse events related to ALT, AST, BUN, or creatinine. CONCLUSION: The proportions of women and infants with severe laboratory adverse events were very low. Increased LPV/r dosing during the third trimester of pregnancy appears to be safe for HIV-infected women and their infants.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12381/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjosehenrique_pílotto_etal_IOC_2011.pdfjosehenrique_pílotto_etal_IOC_2011.pdfapplication/pdf889775https://www.arca.fiocruz.br/bitstream/icict/12381/2/josehenrique_p%c3%adlotto_etal_IOC_2011.pdfbede9287165c592266c12ec467cbdfe6MD52TEXTjosehenrique_pílotto_etal_IOC_2011.pdf.txtjosehenrique_pílotto_etal_IOC_2011.pdf.txtExtracted texttext/plain35445https://www.arca.fiocruz.br/bitstream/icict/12381/3/josehenrique_p%c3%adlotto_etal_IOC_2011.pdf.txtd5a28777db8177e11e6b53f5bb97e212MD53icict/123812023-09-05 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| dc.title.pt_BR.fl_str_mv |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| title |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| spellingShingle |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities Peixoto, Mario Ferreira Gravidez Inibidores da Protease HIV HIV Toxicidade Lopinavir Ritonavir Pregnancy HIV HIV protease inhibitors Drug toxicity |
| title_short |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| title_full |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| title_fullStr |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| title_full_unstemmed |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| title_sort |
Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities |
| author |
Peixoto, Mario Ferreira |
| author_facet |
Peixoto, Mario Ferreira Pilotto, José Henrique Stoszek, Sonia Karolina Kreitchmann, Regis Pinhata, Marisa Márcia Mussi Melo, Victor Hugo João, Esaú Custodio Ceriotto, Mariana Souza, Ricardo da Silva de Read, Jennifer |
| author_role |
author |
| author2 |
Pilotto, José Henrique Stoszek, Sonia Karolina Kreitchmann, Regis Pinhata, Marisa Márcia Mussi Melo, Victor Hugo João, Esaú Custodio Ceriotto, Mariana Souza, Ricardo da Silva de Read, Jennifer |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Peixoto, Mario Ferreira Pilotto, José Henrique Stoszek, Sonia Karolina Kreitchmann, Regis Pinhata, Marisa Márcia Mussi Melo, Victor Hugo João, Esaú Custodio Ceriotto, Mariana Souza, Ricardo da Silva de Read, Jennifer |
| dc.subject.other.pt_BR.fl_str_mv |
Gravidez Inibidores da Protease HIV HIV Toxicidade Lopinavir Ritonavir |
| topic |
Gravidez Inibidores da Protease HIV HIV Toxicidade Lopinavir Ritonavir Pregnancy HIV HIV protease inhibitors Drug toxicity |
| dc.subject.en.pt_BR.fl_str_mv |
Pregnancy HIV HIV protease inhibitors Drug toxicity |
| description |
Hospital Femina. Unidade de Prevenção à Transmissão Vertical. Porto Alegre, RS, Brasil. |
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2011 |
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2011 |
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2015-12-10T14:49:37Z |
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2015-12-10T14:49:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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PEIXOTO, Mario Ferreira; et al. Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities. Braz J Infect Dis., v.15, n.3, May/June 2011. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/12381 |
| dc.identifier.issn.none.fl_str_mv |
1413-8670 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S1413-86702011000300013 |
| identifier_str_mv |
PEIXOTO, Mario Ferreira; et al. Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities. Braz J Infect Dis., v.15, n.3, May/June 2011. 1413-8670 10.1590/S1413-86702011000300013 |
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openAccess |
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Brazilian Society of Infectious Diseases |
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Brazilian Society of Infectious Diseases |
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