Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31455 |
Resumo: | 2020-01-01 |
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Conceição, Emilyn CostaGuimarães, Arthur Emil dos SantosLopes, Maria LuízaFurlaneto, Ismari PeriniRodrigues, Yan CorrêaConceição, Marília Lima daBarros, Wandyra AraújoCardoso, Ninarosa CalzavaraSharma, AbhinavLima, Luana Nepomuceno Gondim CostaGomes, Harrison MagdinierDuarte, Rafael SilvaFrota, CristianeRutaihwa, Liliana K.Gagneux, SebastienSuffys, Philip NoelLima, Karla Valéria Batista2019-02-06T13:54:46Z2019-02-06T13:54:46Z2018CONCEIÇÃO, Emilyn Costa; et al. Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil. Tuberculosis, v.113, p.125-129, 2018.1472-9792https://www.arca.fiocruz.br/handle/icict/3145510.1016/j.tube.2018.09.011engElsevierTuberculoseEpidemiologia molecularContatos domésticosGenotipagemResistência a medicamentosSequenciamento do genoma inteiroTuberculosisHousehold contactsMolecular epidemiologyGenotypingMulti-drug resistanceWhole genome sequencingAnalysis of potential household transmission events of tuberculosis in the city of Belem, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-01-01Universidade Federal do Rio de Janeiro.Instituto de Microbiologia Paulo de Goés.Rio de Janeiro, Brasil.Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil.Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Belém, PA, Brasil.Universidade Federal do Pará. Hospital Universitário João de Barros Barreto. Belém, PA, Brasil.University of Delhi. Delhi College of Engineering. New Delhi, India .Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Belém, PA, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada as Micobactérias, Rio de Janeiro, Brasil.Universidade Federal do Rio de Janeiro.Instituto de Microbiologia Paulo de Goés.Rio de Janeiro, Brasil.Universidade Federal do Ceará. Departamento de Patologia e Medicina Legal. Fortaleza, CE, Brasil.Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland.Swiss Tropical & Public Health Institute. Basel, Switzerland / University of Basel. Basel, Switzerland.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular Aplicada as Micobactérias, Rio de Janeiro, Brasil.Universidade do Estado do Pará. Programa de Pós-graduação em Biologia Parasitária na Amazônia. Belém, PA, Brasil / Instituto Evandro Chagas. Seção de Bacteriologia e Micologia. Belém, PA, Brasil.Tuberculosis (TB) is an infectious disease with a higher risk for infection and disease among household contacts (HHC). Here, we report a molecular epidemiology-based approach to study disease transmission and the genetic characteristics of Mycobacterium tuberculosis (Mtb) strains among HHC in the city of Belem, the capital of the state of Para in north Brazil. The study included 63 TB patients belonging to 26 HHC groups (HHC1 to HHC26). Spoligotyping and 24-loci Mycobacterial Interspersed Repetitive Unit - Variable Number of Tandem Repeat (MIRU-VNTR) revealed indistinguishable bacterial genotypes among 26 patients in 14 (53.8%) HHC groups. Drug susceptibility testing (DST) revealed that 45 (71.4%) of the Mtb isolates were multidrug resistant. The major cluster composed of isolates from five HHCs and on three of these, whole genome sequencing (WGS) was performed confirming their high genetic similarity. These results pinpoint the need for improved vigilance for TB control in households in the city of Belém. When comparing WGS versus phenotypic resistance detection methods as DST and Minimum Inhibitory Concentration (MIC) our data suggest that depending on the colonies selection, results may present variation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31455/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHarrisonMagdnier_etal_IOC_2018.pdfHarrisonMagdnier_etal_IOC_2018.pdfapplication/pdf954186https://www.arca.fiocruz.br/bitstream/icict/31455/2/HarrisonMagdnier_etal_IOC_2018.pdff0846f4960b19055538bb51c95f944f6MD52TEXTHarrisonMagdnier_etal_IOC_2018.pdf.txtHarrisonMagdnier_etal_IOC_2018.pdf.txtExtracted texttext/plain24461https://www.arca.fiocruz.br/bitstream/icict/31455/3/HarrisonMagdnier_etal_IOC_2018.pdf.txtae6bf43e6c820d30c56284403840eff6MD53icict/314552023-09-05 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dc.title.pt_BR.fl_str_mv |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
title |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
spellingShingle |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil Conceição, Emilyn Costa Tuberculose Epidemiologia molecular Contatos domésticos Genotipagem Resistência a medicamentos Sequenciamento do genoma inteiro Tuberculosis Household contacts Molecular epidemiology Genotyping Multi-drug resistance Whole genome sequencing |
title_short |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
title_full |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
title_fullStr |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
title_full_unstemmed |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
title_sort |
Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil |
author |
Conceição, Emilyn Costa |
author_facet |
Conceição, Emilyn Costa Guimarães, Arthur Emil dos Santos Lopes, Maria Luíza Furlaneto, Ismari Perini Rodrigues, Yan Corrêa Conceição, Marília Lima da Barros, Wandyra Araújo Cardoso, Ninarosa Calzavara Sharma, Abhinav Lima, Luana Nepomuceno Gondim Costa Gomes, Harrison Magdinier Duarte, Rafael Silva Frota, Cristiane Rutaihwa, Liliana K. Gagneux, Sebastien Suffys, Philip Noel Lima, Karla Valéria Batista |
author_role |
author |
author2 |
Guimarães, Arthur Emil dos Santos Lopes, Maria Luíza Furlaneto, Ismari Perini Rodrigues, Yan Corrêa Conceição, Marília Lima da Barros, Wandyra Araújo Cardoso, Ninarosa Calzavara Sharma, Abhinav Lima, Luana Nepomuceno Gondim Costa Gomes, Harrison Magdinier Duarte, Rafael Silva Frota, Cristiane Rutaihwa, Liliana K. Gagneux, Sebastien Suffys, Philip Noel Lima, Karla Valéria Batista |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Conceição, Emilyn Costa Guimarães, Arthur Emil dos Santos Lopes, Maria Luíza Furlaneto, Ismari Perini Rodrigues, Yan Corrêa Conceição, Marília Lima da Barros, Wandyra Araújo Cardoso, Ninarosa Calzavara Sharma, Abhinav Lima, Luana Nepomuceno Gondim Costa Gomes, Harrison Magdinier Duarte, Rafael Silva Frota, Cristiane Rutaihwa, Liliana K. Gagneux, Sebastien Suffys, Philip Noel Lima, Karla Valéria Batista |
dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Epidemiologia molecular Contatos domésticos Genotipagem Resistência a medicamentos Sequenciamento do genoma inteiro |
topic |
Tuberculose Epidemiologia molecular Contatos domésticos Genotipagem Resistência a medicamentos Sequenciamento do genoma inteiro Tuberculosis Household contacts Molecular epidemiology Genotyping Multi-drug resistance Whole genome sequencing |
dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Household contacts Molecular epidemiology Genotyping Multi-drug resistance Whole genome sequencing |
description |
2020-01-01 |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-02-06T13:54:46Z |
dc.date.available.fl_str_mv |
2019-02-06T13:54:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CONCEIÇÃO, Emilyn Costa; et al. Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil. Tuberculosis, v.113, p.125-129, 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31455 |
dc.identifier.issn.pt_BR.fl_str_mv |
1472-9792 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.tube.2018.09.011 |
identifier_str_mv |
CONCEIÇÃO, Emilyn Costa; et al. Analysis of potential household transmission events of tuberculosis in the city of Belem, Brazil. Tuberculosis, v.113, p.125-129, 2018. 1472-9792 10.1016/j.tube.2018.09.011 |
url |
https://www.arca.fiocruz.br/handle/icict/31455 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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