Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Freitas, Dayvison Francis Saraiva
Data de Publicação: 2014
Outros Autores: Valle, Antonio Carlos Francesconi do, Silva, Margarete Bernardo Tavares da, Campos, Dayse Pereira, Lyra, Marcelo Rosandiski, Souza, Rogerio Valls de, Veloso, Valdiléa G., Zancopé-Oliveira, Rosely Maria, Bastos, Francisco Inácio Pinkusfeld Monteiro, Galhardo, Maria Clara Gutierrez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9298
Resumo: Financial support was received from FAPERJ/Rio de Janeiro, Brazil (grant proc. E-26/110.619/2012) and PAPES VI – CNPq/Fiocruz (grant proc. 407693/2012-2). DFSF received financial support from CNPq and CAPES. RMZO was supported in part by CNPq (350338/2000-0) and FAPERJ (E-26/103.157/2011). MCGG received partial funding from the Brazilian National STD/AIDS Program, Ministry of Health (46/CV079/2006). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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spelling Freitas, Dayvison Francis SaraivaValle, Antonio Carlos Francesconi doSilva, Margarete Bernardo Tavares daCampos, Dayse PereiraLyra, Marcelo RosandiskiSouza, Rogerio Valls deVeloso, Valdiléa G.Zancopé-Oliveira, Rosely MariaBastos, Francisco Inácio Pinkusfeld MonteiroGalhardo, Maria Clara Gutierrez2014-12-10T11:49:21Z2015-01-05T15:49:41Z2014-12-10T11:49:21Z2015-01-05T15:49:41Z2014FREITAS, Dayvison Francis Saraiva et al. Sporotrichosis: an emerging neglected opportunistic infection in hiv-infected patients in rio de janeiro, brazil. PLoS Neglected Tropical Diseases, v. 8, n. 8, p. 1-8, Aug. 2014.1935-2735https://www.arca.fiocruz.br/handle/icict/9298DOI:10.1371/journal.pntd.0003110Financial support was received from FAPERJ/Rio de Janeiro, Brazil (grant proc. E-26/110.619/2012) and PAPES VI – CNPq/Fiocruz (grant proc. 407693/2012-2). DFSF received financial support from CNPq and CAPES. RMZO was supported in part by CNPq (350338/2000-0) and FAPERJ (E-26/103.157/2011). MCGG received partial funding from the Brazilian National STD/AIDS Program, Ministry of Health (46/CV079/2006). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Comunicação e Informação Científica e Tecnológica em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Sporotrichosis associated with zoonotic transmission remains a relevant public health problem in Rio de Janeiro, Brazil, affecting a large at-risk population, which includes HIV-infected individuals. We assessed patients co-infected by Sporothrix spp. and HIV over time in the context of an unabated sporotrichosis epidemic. A retrospective cohort retrieved information from a National reference institute for infectious diseases regarding 48 patients with sporotrichosis-HIV co-infection (group 1) as well as 3,570 patients with sporotrichosis (group 2), from 1987 through March 2013. Most patients from group 1 were male (68.8%), whereas women were predominant in group 2 (69.1%; p,0.0001). Patients from group 1 were younger than those from group 2 (m = 38.38610.17 vs. 46.34615.85; p,0.001) and differed from group 2 in terms of their race/ethnic background, with 70.8% non-white patients in group 1 vs. 38.6% from group 2 (p,0.0001). Close to half (,44%) of the patients from group 1 were hospitalized due to sporotrichosis over time, whereas hospitalization was very unlikely in group 2, among whom approximately 1% were hospitalized over time. Dissemination of sporotrichosis was the main cause of hospitalization in both groups, although it was more common among hospitalized patients from group 1 (19/21 [90.5%] vs. 16/37 [43.2%]; p,0.001). Over the period under analysis, eight patients died due to sporotrichosis (3/48 vs. 5/3,570). The diagnosis of sporotrichosis elicited HIV testing and subsequent diagnosis in 19/48 patients, whereas 23/48 patients were simultaneously diagnosed with the two infections. HIV infection aggravates sporotrichosis, with a higher incidence of severe disseminated cases and a higher number of hospitalizations and deaths. Underserved populations, among whom sporotrichosis has been propagated, have been affected by different transmissible (e.g., HIV) and non-transmissible diseases. These populations should be targeted by community development programs and entitled to integrated management and care of their superimposed burdens.engPublic Library of ScienceSporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSporotrichosisHIVHIV-Infected PatientsPublic healthSporotrichosis epidemicSubcutaneous mycosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALFREITAS_VALLE_ETAL_ICICT_2014.pdfapplication/pdf654433https://www.arca.fiocruz.br/bitstream/icict/9298/1/FREITAS_VALLE_ETAL_ICICT_2014.pdfdd88f22130cb7f420ee45a2f00fb374bMD51LICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9298/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTFREITAS_VALLE_ETAL_ICICT_2014.pdf.txtFREITAS_VALLE_ETAL_ICICT_2014.pdf.txtExtracted texttext/plain38230https://www.arca.fiocruz.br/bitstream/icict/9298/3/FREITAS_VALLE_ETAL_ICICT_2014.pdf.txt1122a09f961655674e7d307297e04a40MD53icict/92982023-08-23 13:25:19.919oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-23T16:25:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
title Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
spellingShingle Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
Freitas, Dayvison Francis Saraiva
Sporotrichosis
HIV
HIV-Infected Patients
Public health
Sporotrichosis epidemic
Subcutaneous mycosis
title_short Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
title_full Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
title_fullStr Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
title_full_unstemmed Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
title_sort Sporotrichosis: an emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro, Brazil
author Freitas, Dayvison Francis Saraiva
author_facet Freitas, Dayvison Francis Saraiva
Valle, Antonio Carlos Francesconi do
Silva, Margarete Bernardo Tavares da
Campos, Dayse Pereira
Lyra, Marcelo Rosandiski
Souza, Rogerio Valls de
Veloso, Valdiléa G.
Zancopé-Oliveira, Rosely Maria
Bastos, Francisco Inácio Pinkusfeld Monteiro
Galhardo, Maria Clara Gutierrez
author_role author
author2 Valle, Antonio Carlos Francesconi do
Silva, Margarete Bernardo Tavares da
Campos, Dayse Pereira
Lyra, Marcelo Rosandiski
Souza, Rogerio Valls de
Veloso, Valdiléa G.
Zancopé-Oliveira, Rosely Maria
Bastos, Francisco Inácio Pinkusfeld Monteiro
Galhardo, Maria Clara Gutierrez
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Freitas, Dayvison Francis Saraiva
Valle, Antonio Carlos Francesconi do
Silva, Margarete Bernardo Tavares da
Campos, Dayse Pereira
Lyra, Marcelo Rosandiski
Souza, Rogerio Valls de
Veloso, Valdiléa G.
Zancopé-Oliveira, Rosely Maria
Bastos, Francisco Inácio Pinkusfeld Monteiro
Galhardo, Maria Clara Gutierrez
dc.subject.en.none.fl_str_mv Sporotrichosis
HIV
HIV-Infected Patients
Public health
Sporotrichosis epidemic
Subcutaneous mycosis
topic Sporotrichosis
HIV
HIV-Infected Patients
Public health
Sporotrichosis epidemic
Subcutaneous mycosis
description Financial support was received from FAPERJ/Rio de Janeiro, Brazil (grant proc. E-26/110.619/2012) and PAPES VI – CNPq/Fiocruz (grant proc. 407693/2012-2). DFSF received financial support from CNPq and CAPES. RMZO was supported in part by CNPq (350338/2000-0) and FAPERJ (E-26/103.157/2011). MCGG received partial funding from the Brazilian National STD/AIDS Program, Ministry of Health (46/CV079/2006). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-12-10T11:49:21Z
2015-01-05T15:49:41Z
dc.date.available.fl_str_mv 2014-12-10T11:49:21Z
2015-01-05T15:49:41Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv FREITAS, Dayvison Francis Saraiva et al. Sporotrichosis: an emerging neglected opportunistic infection in hiv-infected patients in rio de janeiro, brazil. PLoS Neglected Tropical Diseases, v. 8, n. 8, p. 1-8, Aug. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9298
dc.identifier.issn.pt_BR.fl_str_mv 1935-2735
dc.identifier.doi.pt_BR.fl_str_mv DOI:10.1371/journal.pntd.0003110
identifier_str_mv FREITAS, Dayvison Francis Saraiva et al. Sporotrichosis: an emerging neglected opportunistic infection in hiv-infected patients in rio de janeiro, brazil. PLoS Neglected Tropical Diseases, v. 8, n. 8, p. 1-8, Aug. 2014.
1935-2735
DOI:10.1371/journal.pntd.0003110
url https://www.arca.fiocruz.br/handle/icict/9298
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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