Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine

Detalhes bibliográficos
Autor(a) principal: Espinel-Ingroff, A.
Data de Publicação: 2012
Outros Autores: Chowdhary, A., Cuenca-Estrella, M., Fothergill, A., Fuller, J., Hagen, F., Govender, N., Guarro, J., Johnson, E., Lass-Flörl, C., Lockhart, S. R., Martins, M. A., Meis, J. F., Melhem, M. S., Ostrosky-Zeichner, L., Pelaez, T., Pfaller, M. A., Schell, W. A., Trilles, L., Kidd, S., Turnidge, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36386
Resumo: 2020-04-11
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spelling Espinel-Ingroff, A.Chowdhary, A.Cuenca-Estrella, M.Fothergill, A.Fuller, J.Hagen, F.Govender, N.Guarro, J.Johnson, E.Lass-Flörl, C.Lockhart, S. R.Martins, M. A.Meis, J. F.Melhem, M. S.Ostrosky-Zeichner, L.Pelaez, T.Pfaller, M. A.Schell, W. A.Trilles, L.Kidd, S.Turnidge, J.2019-10-11T14:12:08Z2019-10-11T14:12:08Z2012ESPINEL-INGROFF, A. et al. Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine. Antimicrobial Agents and Chemotherapy, v. 56, n. 6, p. 3107-3113, June 2012.0066-4804https://www.arca.fiocruz.br/handle/icict/3638610.1128/AAC.06252-111098-6596engAmerican Society for MicrobiologyCryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-04-11VCU Medical Center. Richmond, VA, USA.University of Delhi. Vallabhbhai Patel Chest Institute. Delhi, India.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Micología. Pozuelo, Spain.University of Texas. Health Science Center. San Antonio, TX, USA.University of Alberta. Edmonton, AB, Canada.Canisius Wilhelmina Hospital. Department of Medical Microbiology and Infectious Diseases. Nijmegen, The Netherlands.National Institute for Communicable Diseases. Division of the National Health Laboratory Service. Johannesburg, South Africa.Universitat Rovira i Virgili. Facultat de Medicina. Instituto de Investigación Sanitaria Pere Virgili. Reus, Spain.The HPA Mycology Reference Laboratory. Kingsdown, Bristol, UK.The Innsbruck Medical University. Innsbruck, Austria.Centers for Disease Control and Prevention. Atlanta, GA, USA.Adolfo Lutz Institute Public Health Reference Center. Rio Claro, SP, Brazil.Canisius Wilhelmina Hospital. Department of Medical Microbiology and Infectious Diseases. Nijmegen, The Netherlands / Radboud University Medical Centre. Nijmegen, The Netherlands.Adolfo Lutz Institute Public Health Reference Center. Rio Claro, SP, Brazil.University of Texas. Health Science Center. Houston, TX, USA.Universidad Complutense. Facultad de Medicina. Madrid, Spain / Hospital General Universitario Gregorio Marañón, Madrid, Spain.University of Iowa. Iowa City, IA, USA.Duke University Medical Center. Durham, NC, USA.Fundação Oswaldo Cruz. Instituto de Pesquisa Clinica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Women’s and Children’s Hospital. Adelaide, Australia.Women’s and Children’s Hospital. Adelaide, Australia / University of Adelaide. Adelaide, Australia.Clinical breakpoints (CBPs) are not available for the Cryptococcus neoformans-Cryptococcus gattii species complex. MIC distributions were constructed for the wild type (WT) to establish epidemiologic cutoff values (ECVs) for C. neoformans and C. gattii versus amphotericin B and flucytosine. A total of 3,590 amphotericin B and 3,045 flucytosine CLSI MICs for C. neoformans (including 1,002 VNI isolates and 8 to 39 VNII, VNIII, and VNIV isolates) and 985 and 853 MICs for C. gattii, respectively (including 42 to 259 VGI, VGII, VGIII, and VGIV isolates), were gathered in 9 to 16 (amphotericin B) and 8 to 13 (flucytosine) laboratories (Europe, United States, Australia, Brazil, Canada, India, and South Africa) and aggregated for the analyses. Additionally, 442 amphotericin B and 313 flucytosine MICs measured by using CLSI-YNB medium instead of CLSI-RPMI medium and 237 Etest amphotericin B MICs for C. neoformans were evaluated. CLSI-RPMI ECVs for distributions originating in >3 laboratories (with the percentages of isolates for which MICs were less than or equal to ECVs given in parentheses) were as follows: for amphotericin B, 0.5 g/ml for C. neoformans VNI (97.2%) and C. gattii VGI and VGIIa (99.2 and 97.5%, respectively) and 1 g/ml for C. neoformans (98.5%) and C. gattii nontyped (100%) and VGII (99.2%) isolates; for flucytosine, 4 g/ml for C. gattii nontyped (96.4%) and VGI (95.7%) isolates, 8 g/ml for VNI (96.6%) isolates, and 16 g/ml for C. neoformans nontyped (98.6%) and C. gattii VGII (97.1%) isolates. Other molecular types had apparent variations in MIC distributions, but the number of laboratories contributing data was too low to allow us to ascertain that the differences were due to factors other than assay variation. ECVs may aid in the detection of isolates with acquired resistance mechanisms.Cryptococcus neoformansCryptococcus gattiiAmphotericin BFlucytosineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36386/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Espinel-Ingroff_A_etal_INI_2012.pdfve_Espinel-Ingroff_A_etal_INI_2012.pdfapplication/pdf180061https://www.arca.fiocruz.br/bitstream/icict/36386/2/ve_Espinel-Ingroff_A_etal_INI_2012.pdf5730244ca602233acab55f6dbef70d2eMD52TEXTve_Espinel-Ingroff_A_etal_INI_2012.pdf.txtve_Espinel-Ingroff_A_etal_INI_2012.pdf.txtExtracted texttext/plain43391https://www.arca.fiocruz.br/bitstream/icict/36386/3/ve_Espinel-Ingroff_A_etal_INI_2012.pdf.txte8ab488dabd0c8fffdf907470c928d3eMD53icict/363862021-03-24 16:32:30.568oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:30Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
title Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
spellingShingle Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
Espinel-Ingroff, A.
Cryptococcus neoformans
Cryptococcus gattii
Amphotericin B
Flucytosine
title_short Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
title_full Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
title_fullStr Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
title_full_unstemmed Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
title_sort Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine
author Espinel-Ingroff, A.
author_facet Espinel-Ingroff, A.
Chowdhary, A.
Cuenca-Estrella, M.
Fothergill, A.
Fuller, J.
Hagen, F.
Govender, N.
Guarro, J.
Johnson, E.
Lass-Flörl, C.
Lockhart, S. R.
Martins, M. A.
Meis, J. F.
Melhem, M. S.
Ostrosky-Zeichner, L.
Pelaez, T.
Pfaller, M. A.
Schell, W. A.
Trilles, L.
Kidd, S.
Turnidge, J.
author_role author
author2 Chowdhary, A.
Cuenca-Estrella, M.
Fothergill, A.
Fuller, J.
Hagen, F.
Govender, N.
Guarro, J.
Johnson, E.
Lass-Flörl, C.
Lockhart, S. R.
Martins, M. A.
Meis, J. F.
Melhem, M. S.
Ostrosky-Zeichner, L.
Pelaez, T.
Pfaller, M. A.
Schell, W. A.
Trilles, L.
Kidd, S.
Turnidge, J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Espinel-Ingroff, A.
Chowdhary, A.
Cuenca-Estrella, M.
Fothergill, A.
Fuller, J.
Hagen, F.
Govender, N.
Guarro, J.
Johnson, E.
Lass-Flörl, C.
Lockhart, S. R.
Martins, M. A.
Meis, J. F.
Melhem, M. S.
Ostrosky-Zeichner, L.
Pelaez, T.
Pfaller, M. A.
Schell, W. A.
Trilles, L.
Kidd, S.
Turnidge, J.
dc.subject.en.pt_BR.fl_str_mv Cryptococcus neoformans
Cryptococcus gattii
Amphotericin B
Flucytosine
topic Cryptococcus neoformans
Cryptococcus gattii
Amphotericin B
Flucytosine
description 2020-04-11
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-11T14:12:08Z
dc.date.available.fl_str_mv 2019-10-11T14:12:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESPINEL-INGROFF, A. et al. Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine. Antimicrobial Agents and Chemotherapy, v. 56, n. 6, p. 3107-3113, June 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36386
dc.identifier.issn.pt_BR.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.06252-11
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv ESPINEL-INGROFF, A. et al. Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine. Antimicrobial Agents and Chemotherapy, v. 56, n. 6, p. 3107-3113, June 2012.
0066-4804
10.1128/AAC.06252-11
1098-6596
url https://www.arca.fiocruz.br/handle/icict/36386
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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