The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14317 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Gisele P.SIlva, Johnatas D.Marques, Patricia S.Albuquerque, Cassiano Felippe Gonçalves deSantos, Heloísa L.Vasconcellos, Ana PaulaTakiya, Christina M.Morales, Marcelo M.Pelosi, PaoloMócsai, AttilaFaria Neto, Hugo C. de CastroRocco, Patricia R. M.2016-05-17T15:25:43Z2016-05-17T15:25:43Z2015OLIVEIRA, Gisele P. et al. The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology. Cellular Physiology and Biochemistry, v.36, p.1644-1658, July 2015.1015-8987https://www.arca.fiocruz.br/handle/icict/1431710.1159/0004303251421-9778engKargerSíndrome da insuficiência respiratória agudaDasatinibCytokinesHistologyLung mechanicsAcute respiratory distress syndromeToll like receptor-4Síndrome do Desconforto Respiratório do AdultoHistologiaCitocinasDasatinibeThe Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Patologia Celular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Fisiologia Celular e Molecular. Rio de Janeiro, RJ, Brasil.University of Genoa. IRCCS San Martino IST. Department of Surgical Sciences and Integrated Diagnostics. Genoa, Italy.Semmelweis University School of Medicine. Departmento of Physiology. Budapest, Hungary.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil.Background/Aims: Evidence suggests that tyrosine-kinase inhibitors may attenuate lung inflammation and fibrosis in experimental acute respiratory distress syndrome (ARDS). We hypothesized that dasatinib, a tyrosine-kinase inhibitor, might act differently depending on the ARDS etiology and the dose. Methods: C57/BL6 mice were divided to be pre-treated with dasatinib (1mg/kg or 10mg/kg) or vehicle (1% dimethyl-sulfoxide) by oral gavage. Thirty-minutes after pre-treatment, mice were subdivided into control (C) or ARDS groups. ARDS animals received Escherichia coli lipopolysaccharide intratracheally (ARDSp) or intraperitoneally (ARDSexp). A new dose of dasatinib or vehicle was administered at 6 and 24h. Results: Forty-eight hours after ARDS induction, dasatinib 1mg/kg yielded: improved lung morphofunction and reduced cells expressing toll-like receptor (TLR)-4 in lung, independent of ARDS etiology; reduced neutrophil and levels of interleukin (IL)-6, IL-10 and transforming growth factor (TGF)-β in ARDSp. The higher dose of dasatinib caused no changes in lung mechanics, diffuse alveolar damage, neutrophil, or cells expressing TLR4, but increased IL-6, vascular endothelial growth factor (VEGF), and cells expressing Fas receptor in lung in ARDSp. In ARDSexp, it improved lung morphofunction, increased VEGF, and reduced cells expressing TLR4. Conclusion: Dasatinib may have therapeutic potential in ARDS independent of etiology, but careful dose monitoring is required.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14317/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcassiano2_albuquerque_etal_IOC_2015.pdfcassiano2_albuquerque_etal_IOC_2015.pdfapplication/pdf2508946https://www.arca.fiocruz.br/bitstream/icict/14317/2/cassiano2_albuquerque_etal_IOC_2015.pdf29d88a583dd1f5c2eca02d6487651e78MD52TEXTcassiano2_albuquerque_etal_IOC_2015.pdf.txtcassiano2_albuquerque_etal_IOC_2015.pdf.txtExtracted texttext/plain56251https://www.arca.fiocruz.br/bitstream/icict/14317/3/cassiano2_albuquerque_etal_IOC_2015.pdf.txt26177c268c8049d6653e74fa3a483f8eMD53icict/143172018-04-02 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| dc.title.pt_BR.fl_str_mv |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| title |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| spellingShingle |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology Oliveira, Gisele P. Síndrome da insuficiência respiratória aguda Dasatinib Cytokines Histology Lung mechanics Acute respiratory distress syndrome Toll like receptor-4 Síndrome do Desconforto Respiratório do Adulto Histologia Citocinas Dasatinibe |
| title_short |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| title_full |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| title_fullStr |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| title_full_unstemmed |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| title_sort |
The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology |
| author |
Oliveira, Gisele P. |
| author_facet |
Oliveira, Gisele P. SIlva, Johnatas D. Marques, Patricia S. Albuquerque, Cassiano Felippe Gonçalves de Santos, Heloísa L. Vasconcellos, Ana Paula Takiya, Christina M. Morales, Marcelo M. Pelosi, Paolo Mócsai, Attila Faria Neto, Hugo C. de Castro Rocco, Patricia R. M. |
| author_role |
author |
| author2 |
SIlva, Johnatas D. Marques, Patricia S. Albuquerque, Cassiano Felippe Gonçalves de Santos, Heloísa L. Vasconcellos, Ana Paula Takiya, Christina M. Morales, Marcelo M. Pelosi, Paolo Mócsai, Attila Faria Neto, Hugo C. de Castro Rocco, Patricia R. M. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Gisele P. SIlva, Johnatas D. Marques, Patricia S. Albuquerque, Cassiano Felippe Gonçalves de Santos, Heloísa L. Vasconcellos, Ana Paula Takiya, Christina M. Morales, Marcelo M. Pelosi, Paolo Mócsai, Attila Faria Neto, Hugo C. de Castro Rocco, Patricia R. M. |
| dc.subject.other.pt_BR.fl_str_mv |
Síndrome da insuficiência respiratória aguda |
| topic |
Síndrome da insuficiência respiratória aguda Dasatinib Cytokines Histology Lung mechanics Acute respiratory distress syndrome Toll like receptor-4 Síndrome do Desconforto Respiratório do Adulto Histologia Citocinas Dasatinibe |
| dc.subject.en.pt_BR.fl_str_mv |
Dasatinib Cytokines Histology Lung mechanics Acute respiratory distress syndrome Toll like receptor-4 |
| dc.subject.decs.pt_BR.fl_str_mv |
Síndrome do Desconforto Respiratório do Adulto Histologia Citocinas Dasatinibe |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho (IBCCF). Laboratório de Investigação Pulmonar. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2016-05-17T15:25:43Z |
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2016-05-17T15:25:43Z |
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OLIVEIRA, Gisele P. et al. The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology. Cellular Physiology and Biochemistry, v.36, p.1644-1658, July 2015. |
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https://www.arca.fiocruz.br/handle/icict/14317 |
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1015-8987 |
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10.1159/000430325 |
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1421-9778 |
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OLIVEIRA, Gisele P. et al. The Effects of Dasatinib in Experimental Acute Respiratory Distress Syndrome Depend on Dose and Etiology. Cellular Physiology and Biochemistry, v.36, p.1644-1658, July 2015. 1015-8987 10.1159/000430325 1421-9778 |
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