Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14706 |
Resumo: | Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil |
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Barbosa, Lúcio MacedoReis, Eliana Almeida GomesSantos, Cláudio R. A. dosCosta, Jackson Mauricio LopesCarmo, Theomira Mauadie de AzevedoAminu, Peace TPitanga, Thassila NogueiraTerashima, Rafael PonceBlank, Walter ASilva, Luciano KalabricReis, Mitermayer Galvão dosBlanton, Ronald Edward2016-06-30T14:32:42Z2016-07-07T11:39:48Z2016-06-30T14:32:42Z2016-07-07T11:39:48Z2016BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016.0020-7519dx.doi.org/10.1016/j.ijpara.2016.01.007https://www.arca.fiocruz.br/handle/icict/14706engElsevierRepeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilCase Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USAFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMercer University School of Medicine. Macon, USACase Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USAFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilCase Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USARepeated treatments with praziquantel reduce schistosomiasis prevalence and morbidity, but transmission persists and populations often recover within a few years. To identify factors associated with persistence, we surveyed and treated all identified Schistosoma mansoni infections in two rural Brazilian communities (Jenipapo and Volta do Rio) in 2009, 2012 and 2013. Eggs were collected from all infected individuals and genotyped with 11 microsatellite markers to evaluate parasite differentiation and diversity. After successive rounds of community-wide treatment, prevalence decreased from 45% to 24% then 16%. Intensity of infection decreased by 57% over this period, and the number of eggs transmitted to the environment decreased by 92%. During all time periods the majority of eggs were excreted by those >15 years of age. The incidence was 23% in 2012 and 15% in 2013, consistent with a decrease in transmission. There was little immigration or gene flow over a distance of 6 km. On reinfection, infrapopulations were moderately differentiated indicating that pretreatment multilocus genotypes were not fully reacquired. The effective population size responded to census population decline more rapidly than differentiation. Reinfection was concentrated in the downstream portion of Jenipapo, consistent with the observed increased human fecal contamination. At this scale and in this area S. mansoni infections exist on a fragmented landscape with a highly focal pattern of transmission that may facilitate future elimination.Effective population sizeGenetic differentiationExtinctionPraziquantelReinfectionSpatial analysisBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBarbosa LM Repeated praziquantel....pdf.txtBarbosa LM Repeated praziquantel....pdf.txtExtracted texttext/plain45758https://www.arca.fiocruz.br/bitstream/icict/14706/4/Barbosa%20LM%20Repeated%20praziquantel....pdf.txt757f126502bc89ee45591eb4c9092acaMD54ORIGINALBarbosa LM Repeated praziquantel....pdfapplication/pdf658303https://www.arca.fiocruz.br/bitstream/icict/14706/2/Barbosa%20LM%20Repeated%20praziquantel....pdf8ac33d0bdd6d54f84525260c7d847818MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14706/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/147062023-03-15 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| dc.title.pt_BR.fl_str_mv |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| title |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| spellingShingle |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission Barbosa, Lúcio Macedo Effective population size Genetic differentiation Extinction Praziquantel Reinfection Spatial analysis Brazil |
| title_short |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| title_full |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| title_fullStr |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| title_full_unstemmed |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| title_sort |
Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission |
| author |
Barbosa, Lúcio Macedo |
| author_facet |
Barbosa, Lúcio Macedo Reis, Eliana Almeida Gomes Santos, Cláudio R. A. dos Costa, Jackson Mauricio Lopes Carmo, Theomira Mauadie de Azevedo Aminu, Peace T Pitanga, Thassila Nogueira Terashima, Rafael Ponce Blank, Walter A Silva, Luciano Kalabric Reis, Mitermayer Galvão dos Blanton, Ronald Edward |
| author_role |
author |
| author2 |
Reis, Eliana Almeida Gomes Santos, Cláudio R. A. dos Costa, Jackson Mauricio Lopes Carmo, Theomira Mauadie de Azevedo Aminu, Peace T Pitanga, Thassila Nogueira Terashima, Rafael Ponce Blank, Walter A Silva, Luciano Kalabric Reis, Mitermayer Galvão dos Blanton, Ronald Edward |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barbosa, Lúcio Macedo Reis, Eliana Almeida Gomes Santos, Cláudio R. A. dos Costa, Jackson Mauricio Lopes Carmo, Theomira Mauadie de Azevedo Aminu, Peace T Pitanga, Thassila Nogueira Terashima, Rafael Ponce Blank, Walter A Silva, Luciano Kalabric Reis, Mitermayer Galvão dos Blanton, Ronald Edward |
| dc.subject.en.pt_BR.fl_str_mv |
Effective population size Genetic differentiation Extinction Praziquantel Reinfection Spatial analysis Brazil |
| topic |
Effective population size Genetic differentiation Extinction Praziquantel Reinfection Spatial analysis Brazil |
| description |
Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil |
| publishDate |
2016 |
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2016-06-30T14:32:42Z 2016-07-07T11:39:48Z |
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2016-06-30T14:32:42Z 2016-07-07T11:39:48Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016. |
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https://www.arca.fiocruz.br/handle/icict/14706 |
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0020-7519 dx.doi.org/10.1016/j.ijpara.2016.01.007 |
| identifier_str_mv |
BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016. 0020-7519 dx.doi.org/10.1016/j.ijpara.2016.01.007 |
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