Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission

Detalhes bibliográficos
Autor(a) principal: Barbosa, Lúcio Macedo
Data de Publicação: 2016
Outros Autores: Reis, Eliana Almeida Gomes, Santos, Cláudio R. A. dos, Costa, Jackson Mauricio Lopes, Carmo, Theomira Mauadie de Azevedo, Aminu, Peace T, Pitanga, Thassila Nogueira, Terashima, Rafael Ponce, Blank, Walter A, Silva, Luciano Kalabric, Reis, Mitermayer Galvão dos, Blanton, Ronald Edward
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14706
Resumo: Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
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spelling Barbosa, Lúcio MacedoReis, Eliana Almeida GomesSantos, Cláudio R. A. dosCosta, Jackson Mauricio LopesCarmo, Theomira Mauadie de AzevedoAminu, Peace TPitanga, Thassila NogueiraTerashima, Rafael PonceBlank, Walter ASilva, Luciano KalabricReis, Mitermayer Galvão dosBlanton, Ronald Edward2016-06-30T14:32:42Z2016-07-07T11:39:48Z2016-06-30T14:32:42Z2016-07-07T11:39:48Z2016BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016.0020-7519dx.doi.org/10.1016/j.ijpara.2016.01.007https://www.arca.fiocruz.br/handle/icict/14706engElsevierRepeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilCase Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USAFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilMercer University School of Medicine. Macon, USACase Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USAFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, BrasilCase Western Reserve University. Center for Global Health and Diseases. Biomedical Research Building. Cleveland, OH, USARepeated treatments with praziquantel reduce schistosomiasis prevalence and morbidity, but transmission persists and populations often recover within a few years. To identify factors associated with persistence, we surveyed and treated all identified Schistosoma mansoni infections in two rural Brazilian communities (Jenipapo and Volta do Rio) in 2009, 2012 and 2013. Eggs were collected from all infected individuals and genotyped with 11 microsatellite markers to evaluate parasite differentiation and diversity. After successive rounds of community-wide treatment, prevalence decreased from 45% to 24% then 16%. Intensity of infection decreased by 57% over this period, and the number of eggs transmitted to the environment decreased by 92%. During all time periods the majority of eggs were excreted by those >15 years of age. The incidence was 23% in 2012 and 15% in 2013, consistent with a decrease in transmission. There was little immigration or gene flow over a distance of 6 km. On reinfection, infrapopulations were moderately differentiated indicating that pretreatment multilocus genotypes were not fully reacquired. The effective population size responded to census population decline more rapidly than differentiation. Reinfection was concentrated in the downstream portion of Jenipapo, consistent with the observed increased human fecal contamination. At this scale and in this area S. mansoni infections exist on a fragmented landscape with a highly focal pattern of transmission that may facilitate future elimination.Effective population sizeGenetic differentiationExtinctionPraziquantelReinfectionSpatial analysisBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBarbosa LM Repeated praziquantel....pdf.txtBarbosa LM Repeated praziquantel....pdf.txtExtracted texttext/plain45758https://www.arca.fiocruz.br/bitstream/icict/14706/4/Barbosa%20LM%20Repeated%20praziquantel....pdf.txt757f126502bc89ee45591eb4c9092acaMD54ORIGINALBarbosa LM Repeated 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dc.title.pt_BR.fl_str_mv Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
title Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
spellingShingle Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
Barbosa, Lúcio Macedo
Effective population size
Genetic differentiation
Extinction
Praziquantel
Reinfection
Spatial analysis
Brazil
title_short Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
title_full Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
title_fullStr Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
title_full_unstemmed Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
title_sort Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission
author Barbosa, Lúcio Macedo
author_facet Barbosa, Lúcio Macedo
Reis, Eliana Almeida Gomes
Santos, Cláudio R. A. dos
Costa, Jackson Mauricio Lopes
Carmo, Theomira Mauadie de Azevedo
Aminu, Peace T
Pitanga, Thassila Nogueira
Terashima, Rafael Ponce
Blank, Walter A
Silva, Luciano Kalabric
Reis, Mitermayer Galvão dos
Blanton, Ronald Edward
author_role author
author2 Reis, Eliana Almeida Gomes
Santos, Cláudio R. A. dos
Costa, Jackson Mauricio Lopes
Carmo, Theomira Mauadie de Azevedo
Aminu, Peace T
Pitanga, Thassila Nogueira
Terashima, Rafael Ponce
Blank, Walter A
Silva, Luciano Kalabric
Reis, Mitermayer Galvão dos
Blanton, Ronald Edward
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barbosa, Lúcio Macedo
Reis, Eliana Almeida Gomes
Santos, Cláudio R. A. dos
Costa, Jackson Mauricio Lopes
Carmo, Theomira Mauadie de Azevedo
Aminu, Peace T
Pitanga, Thassila Nogueira
Terashima, Rafael Ponce
Blank, Walter A
Silva, Luciano Kalabric
Reis, Mitermayer Galvão dos
Blanton, Ronald Edward
dc.subject.en.pt_BR.fl_str_mv Effective population size
Genetic differentiation
Extinction
Praziquantel
Reinfection
Spatial analysis
Brazil
topic Effective population size
Genetic differentiation
Extinction
Praziquantel
Reinfection
Spatial analysis
Brazil
description Fundação Gonçalo Moniz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Bahiana School of Medicine and Public Health. Salvador, BA, Brasil
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-06-30T14:32:42Z
2016-07-07T11:39:48Z
dc.date.available.fl_str_mv 2016-06-30T14:32:42Z
2016-07-07T11:39:48Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14706
dc.identifier.issn.pt_BR.fl_str_mv 0020-7519
dx.doi.org/10.1016/j.ijpara.2016.01.007
identifier_str_mv BARBOSA, L. M. et al. Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission. International Journal for Parasitology, v. 46, p. 343–350, 2016.
0020-7519
dx.doi.org/10.1016/j.ijpara.2016.01.007
url https://www.arca.fiocruz.br/handle/icict/14706
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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