Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis

Detalhes bibliográficos
Autor(a) principal: Pyrrho, Alexandre S.
Data de Publicação: 2004
Outros Autores: Lenzi, Henrique Leonel, Ramos, Juliene Antonio, Moura Neto, Roberto, Cachem, Fabio Christiane O. F., Silva, Célia Santos da, Takiya, Christina Maeda, Gattass, Cerli Rocha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: DOI 10.1007/s00436-004-1078-8
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5486
Resumo: Acknowledgements This work was supported by FAPERJ, CNPq, FUJB, and FIOCRUZ. The authors are grateful to Dr. L. Correa for the Schistosoma mansoni cercariae. All experimental procedures were conducted in accordance with the Guidelines for Care and Use of Laboratory Animals (CAUAP) of the Institute of Biophysics Carlos Chagas Filho, which conform to the National Institute of Health (Bethesda, MD, USA) guidelines.
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spelling Pyrrho, Alexandre S.Lenzi, Henrique LeonelRamos, Juliene AntonioMoura Neto, RobertoCachem, Fabio Christiane O. F.Silva, Célia Santos daTakiya, Christina MaedaGattass, Cerli Rocha2012-09-06T14:04:30Z2012-09-06T14:04:30Z2004PYRRHO, A. S. ; LENZI, H. L. ; RAMOS, J. A. et al. Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schitosomiasis. Parasitology Research, v. 92, n. 6, p. 478-483, 2004.0932-0113https://www.arca.fiocruz.br/handle/icict/5486DOI 10.1007/s00436-004-1078-8Acknowledgements This work was supported by FAPERJ, CNPq, FUJB, and FIOCRUZ. The authors are grateful to Dr. L. Correa for the Schistosoma mansoni cercariae. All experimental procedures were conducted in accordance with the Guidelines for Care and Use of Laboratory Animals (CAUAP) of the Institute of Biophysics Carlos Chagas Filho, which conform to the National Institute of Health (Bethesda, MD, USA) guidelines.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilSchistosomiasis, a chronic disease with considerable social impact, is an important health problem in many countries. To investigate the possible use of immunomodulators as coadjuvants in the treatment of chronic Schistosoma mansoni infection, we evaluated the effect of dexamethasone on histological, hematological, and biochemical parameters that reflect disease severity and morbidity. Animals treated from the first day or after 35 days of infection, were analyzed. In both groups, dexamethasone: (1) induced a decrease in the number of granulomas in hepatic tissue without affecting the alanine aminotransferase profile, (2) reduced splenomegaly and hepatomegaly associated with disease, and (3) improved hemoglobin concentration, hematocrit values and reduced the percentage of reticulocytes, preventing the development of anemia that occurs in the chronic phase of infection. These data suggest that treatment with dexamethasone results in a mild course of murine schistosomiasis and point to this drug as a promising agent to complement S. mansoni specific treatment.engSprmger Verlag (Germany)Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAnti-Inflammatory AgentsSchistosomiasis mansoniDexamethasoneHemoglobinsAlanina TransaminaseAntiinflamatóriosDexametasonaEsquistossomose mansoniHemoglobinasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALDexamethasone treatment improves morphological.pdfDexamethasone treatment improves morphological.pdfapplication/pdf232536https://www.arca.fiocruz.br/bitstream/icict/5486/1/Dexamethasone%20treatment%20improves%20morphological.pdfb84ec2bb6d15a6390f33a0eae6f60727MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5486/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTDexamethasone treatment improves morphological.pdf.txtDexamethasone treatment improves morphological.pdf.txtExtracted texttext/plain25810https://www.arca.fiocruz.br/bitstream/icict/5486/5/Dexamethasone%20treatment%20improves%20morphological.pdf.txt8771b14df6e6096731f0dba95079d86bMD55THUMBNAILDexamethasone treatment improves morphological.pdf.jpgDexamethasone treatment improves morphological.pdf.jpgGenerated Thumbnailimage/jpeg2219https://www.arca.fiocruz.br/bitstream/icict/5486/4/Dexamethasone%20treatment%20improves%20morphological.pdf.jpg189164d1341dad93bf42775b5165374dMD54icict/54862018-04-06 09:06:43.798oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T12:06:43Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
title Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
spellingShingle Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
Pyrrho, Alexandre S.
Anti-Inflammatory Agents
Schistosomiasis mansoni
Dexamethasone
Hemoglobins
Alanina Transaminase
Antiinflamatórios
Dexametasona
Esquistossomose mansoni
Hemoglobinas
title_short Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
title_full Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
title_fullStr Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
title_full_unstemmed Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
title_sort Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schistosomiasis
author Pyrrho, Alexandre S.
author_facet Pyrrho, Alexandre S.
Lenzi, Henrique Leonel
Ramos, Juliene Antonio
Moura Neto, Roberto
Cachem, Fabio Christiane O. F.
Silva, Célia Santos da
Takiya, Christina Maeda
Gattass, Cerli Rocha
author_role author
author2 Lenzi, Henrique Leonel
Ramos, Juliene Antonio
Moura Neto, Roberto
Cachem, Fabio Christiane O. F.
Silva, Célia Santos da
Takiya, Christina Maeda
Gattass, Cerli Rocha
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pyrrho, Alexandre S.
Lenzi, Henrique Leonel
Ramos, Juliene Antonio
Moura Neto, Roberto
Cachem, Fabio Christiane O. F.
Silva, Célia Santos da
Takiya, Christina Maeda
Gattass, Cerli Rocha
dc.subject.en.pt_BR.fl_str_mv Anti-Inflammatory Agents
Schistosomiasis mansoni
Dexamethasone
Hemoglobins
topic Anti-Inflammatory Agents
Schistosomiasis mansoni
Dexamethasone
Hemoglobins
Alanina Transaminase
Antiinflamatórios
Dexametasona
Esquistossomose mansoni
Hemoglobinas
dc.subject.decs.pt_BR.fl_str_mv Alanina Transaminase
Antiinflamatórios
Dexametasona
Esquistossomose mansoni
Hemoglobinas
description Acknowledgements This work was supported by FAPERJ, CNPq, FUJB, and FIOCRUZ. The authors are grateful to Dr. L. Correa for the Schistosoma mansoni cercariae. All experimental procedures were conducted in accordance with the Guidelines for Care and Use of Laboratory Animals (CAUAP) of the Institute of Biophysics Carlos Chagas Filho, which conform to the National Institute of Health (Bethesda, MD, USA) guidelines.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2012-09-06T14:04:30Z
dc.date.available.fl_str_mv 2012-09-06T14:04:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PYRRHO, A. S. ; LENZI, H. L. ; RAMOS, J. A. et al. Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schitosomiasis. Parasitology Research, v. 92, n. 6, p. 478-483, 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5486
dc.identifier.issn.none.fl_str_mv 0932-0113
dc.identifier.doi.none.fl_str_mv DOI 10.1007/s00436-004-1078-8
identifier_str_mv PYRRHO, A. S. ; LENZI, H. L. ; RAMOS, J. A. et al. Dexamethasone treatment improves morphological and hematological parameters in chronic experimental schitosomiasis. Parasitology Research, v. 92, n. 6, p. 478-483, 2004.
0932-0113
DOI 10.1007/s00436-004-1078-8
url https://www.arca.fiocruz.br/handle/icict/5486
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sprmger Verlag (Germany)
publisher.none.fl_str_mv Sprmger Verlag (Germany)
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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