Enterolobin induces rat paw oedema independently of PAF-acether

Detalhes bibliográficos
Autor(a) principal: Faria Neto, H. C. Castro
Data de Publicação: 1991
Outros Autores: Cordeiro, R. S. B., Martins, M. A., Silva, A. C. V. Correira da, Bozza, P. T., Sousa, M. V., Morhy, L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43467
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
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spelling Faria Neto, H. C. CastroCordeiro, R. S. B.Martins, M. A.Silva, A. C. V. Correira daBozza, P. T.Sousa, M. V.Morhy, L.2020-09-18T20:08:53Z2020-09-18T20:08:53Z1991FARIA NETO, H. C. Castro et al. Enterolobin induces rat paw oedema independently of PAF-acether. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 82, Suppl. 2, p. 129-131, 1991.0074-0276https://www.arca.fiocruz.br/handle/icict/4346710.1590/S0074-027619910006000291678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Proteínas de toxinaEdema de pataPAFToxin proteinsPAFPaw oedemaEnterolobin induces rat paw oedema independently of PAF-acetherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Laboratório de Química de Proteínas. Brasília, DF, Brasil.Universidade de Brasília. Departamento de Biologia Celular. Laboratório de Química de Proteínas. Brasília, DF, Brasil.The potential participation of PAF-acether (PAF) on the paw oedema triggered by enterolobin was investigated. Intraplantar injections of enterolobin )5-20 µg/paw) yielded a dose response curve for edema which appeared after 30 min, peaked in the interval between 2-4 h and faded after 24h. The pre-treatment with BN 52021, but not with other PAF antagonists such as PCA 4248 or WEB 2086, significantly blocked enterolobin-induced oedema. To clarify better the discrepant results obtained with the PAF antagonists, desensitization to PAF was performed. The oedema triggered by enterolobin was not modified in paf desensitized animals. It was concluded that the paw inflammation induced by enterolobin does not require PAF mechanism.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43467/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPTBozza_HCFNeto_etal_IOC_1991.pdfPTBozza_HCFNeto_etal_IOC_1991.pdfapplication/pdf153055https://www.arca.fiocruz.br/bitstream/icict/43467/2/PTBozza_HCFNeto_etal_IOC_1991.pdf38247de7c6d2e9a79d4d09a8ce1baf7aMD52TEXTPTBozza_HCFNeto_etal_IOC_1991.pdf.txtPTBozza_HCFNeto_etal_IOC_1991.pdf.txtExtracted texttext/plain3https://www.arca.fiocruz.br/bitstream/icict/43467/3/PTBozza_HCFNeto_etal_IOC_1991.pdf.txt2228e977ebea8966e27929f43e39cb67MD53icict/434672020-09-21 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dc.title.pt_BR.fl_str_mv Enterolobin induces rat paw oedema independently of PAF-acether
title Enterolobin induces rat paw oedema independently of PAF-acether
spellingShingle Enterolobin induces rat paw oedema independently of PAF-acether
Faria Neto, H. C. Castro
Proteínas de toxina
Edema de pata
PAF
Toxin proteins
PAF
Paw oedema
title_short Enterolobin induces rat paw oedema independently of PAF-acether
title_full Enterolobin induces rat paw oedema independently of PAF-acether
title_fullStr Enterolobin induces rat paw oedema independently of PAF-acether
title_full_unstemmed Enterolobin induces rat paw oedema independently of PAF-acether
title_sort Enterolobin induces rat paw oedema independently of PAF-acether
author Faria Neto, H. C. Castro
author_facet Faria Neto, H. C. Castro
Cordeiro, R. S. B.
Martins, M. A.
Silva, A. C. V. Correira da
Bozza, P. T.
Sousa, M. V.
Morhy, L.
author_role author
author2 Cordeiro, R. S. B.
Martins, M. A.
Silva, A. C. V. Correira da
Bozza, P. T.
Sousa, M. V.
Morhy, L.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Faria Neto, H. C. Castro
Cordeiro, R. S. B.
Martins, M. A.
Silva, A. C. V. Correira da
Bozza, P. T.
Sousa, M. V.
Morhy, L.
dc.subject.other.pt_BR.fl_str_mv Proteínas de toxina
Edema de pata
PAF
topic Proteínas de toxina
Edema de pata
PAF
Toxin proteins
PAF
Paw oedema
dc.subject.en.pt_BR.fl_str_mv Toxin proteins
PAF
Paw oedema
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2020-09-18T20:08:53Z
dc.date.available.fl_str_mv 2020-09-18T20:08:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FARIA NETO, H. C. Castro et al. Enterolobin induces rat paw oedema independently of PAF-acether. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 82, Suppl. 2, p. 129-131, 1991.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43467
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761991000600029
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv FARIA NETO, H. C. Castro et al. Enterolobin induces rat paw oedema independently of PAF-acether. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 82, Suppl. 2, p. 129-131, 1991.
0074-0276
10.1590/S0074-02761991000600029
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43467
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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