Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.

Detalhes bibliográficos
Autor(a) principal: Moreira Júnior, Edson Duarte
Data de Publicação: 2014
Outros Autores: Giuliano, Anna R., Palefsky, Joel M., Flores, Carlos Aranda, Goldstone, Stephen, Ferris, Daron G., Hillman, Richard J., Moi, Harald, Stoler, Mark H., Marshall, J. Brooke, Vuocolo, Scott, Guris, Dalya, Haupt, Richard M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8091
Resumo: Associação Obras Sociais Irmã Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Moreira Júnior, Edson DuarteGiuliano, Anna R.Palefsky, Joel M.Flores, Carlos ArandaGoldstone, StephenFerris, Daron G.Hillman, Richard J.Moi, HaraldStoler, Mark H.Marshall, J. BrookeVuocolo, ScottGuris, DalyaHaupt, Richard M.2014-07-28T16:59:41Z2014-07-28T16:59:41Z2014MOREIRA JUNIOR, E. D. et al. Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men. Journal of Infectious Disease, v. 210, n. 2, p. 192-199, 2014.0022-1899https://www.arca.fiocruz.br/handle/icict/809110.1093/infdis/jiu077engOxford University PressIncidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAssociação Obras Sociais Irmã Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.Center for Infection Research in Cancer. H. Lee Moffitt Cancer Center and Research Institute. Tampa, Florida.University of California. Department of Medicine. San Francisco.University Medical Center. National Public Health Institute. Morelos, Mexico.Mount Sinai School of Medicine. New York, NY, USA.Gynecologic Cancer Prevention Center Georgia Health Sciences University. Augusta.Western Sydney Sexual Health Centre. University of Sydney. Australia.University of Oslo. Olafia STI Clinic. Oslo University Hospital. Norway.University of Virginia. Charlottesville.Merck. North Wales. Pennsylvania.Merck. North Wales. Pennsylvania.Merck. North Wales. Pennsylvania.Merck. North Wales. Pennsylvania.BACKGROUND: In this analysis, we examine the incidence and clearance of external genital human papillomavirus (HPV) infection among heterosexual males aged 16-24 years. METHODS: A total of 1732 males aged 16-24 years old in the placebo arm of a quadrivalent HPV vaccine trial were included in this analysis. Participants were enrolled from 18 countries in Africa, the Asia-Pacific region, Europe, Latin America, and North America. Subjects underwent anogenital examinations and sampling of the penis, scrotum, and perineal/perianal regions. RESULTS: The incidence rate of any HPV DNA genotype 6, 11, 16, and/or 18 detection was 9.0 cases per 100 person-years. Rates of HPV DNA detection were highest in men from Africa. Median time to clearance of HPV genotypes 6, 11, 16, and 18 DNA was 6.1, 6.1, 7.7, and 6.2 months, respectively. Median time to clearance of persistently detected HPV 6, 11, 16, and 18 DNA was 6.7, 3.2, 9.2, and 4.7 months, respectively. CONCLUSION: The study results suggest that the acquisition of HPV 6, 11, 16, and/or 18 in males is common and that many of these so-called infections are subsequently cleared, similar to findings for women. Nevertheless, given the high rate of HPV detection among young men, HPV vaccination of males may reduce infection in men and reduce the overall burden of HPV-associated disease in the community.HPVIncidenceProgressionMalesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMoreira JR ED Incidence....pdfMoreira JR ED Incidence....pdfapplication/pdf291970https://www.arca.fiocruz.br/bitstream/icict/8091/1/Moreira%20JR%20ED%20Incidence....pdf7693bccee24be3958443377418f4d398MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8091/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMoreira JR ED Incidence....pdf.txtMoreira JR ED Incidence....pdf.txtExtracted texttext/plain39869https://www.arca.fiocruz.br/bitstream/icict/8091/3/Moreira%20JR%20ED%20Incidence....pdf.txt3eb363afe7624a6f1bcaa8e54b574acbMD53icict/80912023-03-15 14:33:01.916oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:01Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
title Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
spellingShingle Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
Moreira Júnior, Edson Duarte
HPV
Incidence
Progression
Males
title_short Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
title_full Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
title_fullStr Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
title_full_unstemmed Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
title_sort Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men.
author Moreira Júnior, Edson Duarte
author_facet Moreira Júnior, Edson Duarte
Giuliano, Anna R.
Palefsky, Joel M.
Flores, Carlos Aranda
Goldstone, Stephen
Ferris, Daron G.
Hillman, Richard J.
Moi, Harald
Stoler, Mark H.
Marshall, J. Brooke
Vuocolo, Scott
Guris, Dalya
Haupt, Richard M.
author_role author
author2 Giuliano, Anna R.
Palefsky, Joel M.
Flores, Carlos Aranda
Goldstone, Stephen
Ferris, Daron G.
Hillman, Richard J.
Moi, Harald
Stoler, Mark H.
Marshall, J. Brooke
Vuocolo, Scott
Guris, Dalya
Haupt, Richard M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moreira Júnior, Edson Duarte
Giuliano, Anna R.
Palefsky, Joel M.
Flores, Carlos Aranda
Goldstone, Stephen
Ferris, Daron G.
Hillman, Richard J.
Moi, Harald
Stoler, Mark H.
Marshall, J. Brooke
Vuocolo, Scott
Guris, Dalya
Haupt, Richard M.
dc.subject.en.pt_BR.fl_str_mv HPV
Incidence
Progression
Males
topic HPV
Incidence
Progression
Males
description Associação Obras Sociais Irmã Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2014
dc.date.accessioned.fl_str_mv 2014-07-28T16:59:41Z
dc.date.available.fl_str_mv 2014-07-28T16:59:41Z
dc.date.issued.fl_str_mv 2014
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOREIRA JUNIOR, E. D. et al. Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men. Journal of Infectious Disease, v. 210, n. 2, p. 192-199, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8091
dc.identifier.issn.none.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jiu077
identifier_str_mv MOREIRA JUNIOR, E. D. et al. Incidence, clearance, and disease progression of genital human papillomavirus infection in heterosexual men. Journal of Infectious Disease, v. 210, n. 2, p. 192-199, 2014.
0022-1899
10.1093/infdis/jiu077
url https://www.arca.fiocruz.br/handle/icict/8091
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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