The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42701 |
Resumo: | Carvalho, Ana Cristina Calçada. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.; Croda, Julio Henrique Rosa. Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
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Martinez, LeonardoCords, OliviaAcuna-Villaorduña, CarlosAhuja, Shama DesaiAltet, NeusAugusto, OrvalhoBaliashvili, DavitBasu, SanjayBecerra, MercedesBonnet, MarylineBoom, W. HenryBorgdorf, MartienBoulahbal, FadilaCarvalho, Anna Cristina CalçadaCayla, Joan A.Chakhaia, TsiraCohen, TedPei-Chun, ChanCroda, Julio Henrique RosaDatta, SumonaCorral, Helena delDenholm, Justin T.Dietze, ReynaldoDobler, Claudia C.Donkor, SimonEgere, UzochukwuEllner, Jerrold J.Espinal, MarcosEvans, Carlton A.Chi-Tai, FangFielding, KatherineFox, Greg J.García, Luis F.García-Basteiro, Alberto L.Geis, SteffenGraham, Stephen M.Grandjean, LouisHannoun, DjoharHatherill, MarkHauri, Anja M.Hesseling, Anneke C.Hill, Philip C.Li-Min, HuangHuerga, HelenaHussain, RabiaJarlsberg, LeahJones-López, Edward C.Kato, SeiyaKato-Maeda, MidoriKampmann, BeateKirchner, H. LesterKritski, AfrânioLange, ChristophMeng-Rui, LeeLi-Na, LeeChih-Hsin, LeeLemos, Antonio CarlosLienhardt, ChristianDu-Lin, LingQiao, LiuLo, Nathan C.Long, RichardLopez-Varela, ElisaPeng, LuMagee, MatthewMalone, LaShaunda L.Mandalakas, Anna M.Martinson, Neil A.Mazahir, RufaidaMurray, Megan B.Martins Netto, EduardoOtero, LarissaParsonnet, JulieReingold, ArthurSchaaf, H. SimonSeddon, James A.Sharma, SurendraSingh, JitendraSingh, SarmanSloot, RosaSotgiu, GiovanniStein, Catherine M.Iqbal, Najeeha TalatTriasih, RinaTrieu, LisaLoeff, Maarten F. Schim van derStuyft, Patrick van derSchalkwyk, Cari vanVashishtha, RichaVerhagen, Lilly M.Villalba, Julian A.Jann-Yuan, WangWhalen, Christopher C.Yoshiyama, TakashiZar, Heather J.Zellweger, Jean-PierreLimei, ZhuHorsburgh, C. RobertAndrews, Jason R.2020-08-12T12:20:49Z2020-08-12T12:20:49Z2020MARTINEZ, Leonardo et al. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis. The Lancet, v. 395, n. 10228, p. 973-984, 21 Mar. 2020.1474-547Xhttps://www.arca.fiocruz.br/handle/icict/4270110.1016/S0140-6736(20)30166-5Carvalho, Ana Cristina Calçada. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.; Croda, Julio Henrique Rosa. Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA (L Martinez PhD, O Cords MS, N C Lo MD, J Parsonnet MD, J R Andrews MD); Division of Epidemiology, Stanford University School of Medicine, Stanford, CA, USA (N C Lo MD); Department of Medicine, Boston Medical Center, Boston, MA, USA (C Acuna-Villaorduña MD, C R Horsburgh MD, E C Jones-López MD); Departments of Epidemiology, Biostatistics, and Global Health, Boston University School of Public Health, Boston, MA, USA (C R Horsburgh MD); Bureau of Tuberculosis Control, New York City Department of Health and Mental Hygiene, Queens, NY, USA (S D Ahuja PhD, L Trieu MPH); Unidad de Tuberculosis Vall d’Hebron-Drassanes, Hospital Universitari Vall d’Hebron, Barcelona, Spain (N Altet MD); Instituto de Investigación en Atención Primaria Jordi Gol, Barcelona, Spain (N Altet MD); Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique (O Augusto MPH); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA (D Baliashvili MD); National Center for Disease Control and Public Health, Tbilisi, Georgia (D Baliashvili MD); Center for Primary Care, Harvard Medical School, Boston, MA, USA (S Basu PhD); Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA (M Becerra ScD, M Murray MD); Unité Mixte Internationale Trans VIHMI (UMI 233 IRD–U1175 INSERM, Université de Montpellier), Institut de Recherche pour le Développement (IRD), Montpellier, France (M Bonnet MD, C Lienhardt PhD); Center for Infections and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands (M Borgdorff PhD, R Sloot PhD); Department of Infectious Diseases, Public Health Service, Amsterdam, Netherlands (M Borgdorff PhD, M F Schim van der Loeff MD); Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Public Health Service, Amsterdam, Netherlands (R Sloot PhD); Groupe de recherche sur la tuberculose latente, Laboratoire National de Référence pour la Tuberculose, Institut Pasteur d’Algérie, Algiers, Algeria (F Boulahbal MD); Laboratory of Innovations in Therapies, Education and Bioproducts (LITEB), Oswaldo Cruz Institute (IOC), FioCruz, Rio de Janeiro, Brazil (A C Carvalho MD); Epidemiology Service, Agència de Salut Pública de Barcelona, Barcelona, Spain (J A Cayla MD); Foundation of the Tuberculosis Research Unit of Barcelona (fuiTB), Barcelona, Spain (J A Cayla MD); National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia (T Chakhaia MD); School of Public Health, Georgia State University, Atlanta, GA, USA (T Chakhaia MD); Division of Chronic Infectious Disease, Taiwan Centers for Disease Control, Taipei, Taiwan (P C Chan MD); Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan (P C Chan MD, L Huang MD); College of Medicine and College of Public Health, National Taiwan University, Taipei, Taiwan (L Huang MD); Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan (P Chan MD, C Fang PhD); Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (J Wang PhD, M Lee, C Fang PhD); Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA (T Cohen DPH); Oswaldo Cruz Foundation, Mato Grosso do Sul, Brazil (J Croda PhD); Grupo de Epidemiologıa, Universidad de Antioquia, Medellin, Colombia (H del Corral PhD); Grupo de Inmunología Celular e Inmunogenética, Facultad de Medicina, Sede de Investigación Universitaria, Universidad de Antioquia, Medellin, Colombia (H del Corral PhD, L F García MD); Victorian Tuberculosis Program, Melbourne Health, Melbourne, VIC, Australia; Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia (J Denholm PhD); Núcleo de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitória, Brazil (R Dietze MD); Global Health & Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisbon, Portugal (R Dietze MD); Institute for Evidence-Based Healthcare, Bond University and Gold Coast University Hospital, Gold Coast, QLD, Australia (C Dobler MD); Department of Respiratory Medicine, Liverpool Hospital, Sydney, NSW, Australia (C Dobler MD); Vaccines and Immunity Theme, Medical Research Council Unit, Banjul, The Gambia (B Kampmann MD, S Donkor Msc); Department of International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK (U Egere PhD); Department of Medicine, Center for Emerging Pathogens, Rutgers-New Jersey Medical School, Newark, NJ, USA (J J Ellner MD); Pan American Health Organization, Communicable Diseases and Environmental Determinants of Health, Washington, DC, USA (M Espinal MD); Innovation for Health and Development (IFHAD), Laboratory of Research and Development, Universidad Peruana Cayetano Heredia, Lima, Peru (C A Evans PhD, S Datta MD); Department of Infectious Disease, Imperial College London, London, UK (C A Evans PhD, S Datta MD, J A Seddon PhD); Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK (K Fielding PhD); Sydney Medical School, Camperdown, NSW, Australia (G Fox PhD); Woolcock Institute of Medical Research, Glebe, NSW, Australia (G Fox PhD); Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique (A L García-Basteiro PhD, E Lopez-Varela PhD); ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain (A L García-Basteiro PhD, E Lopez-Varela PhD); Institute for Medical Microbiology and Hospital Hygiene, Philipps University of Marburg, Marburg, Germany (S Geis MD); Centre for International Health, University of Melbourne Department of Paediatrics and Murdoch Children’s Research Institute, Royal Children’s Hospital, Melbourne, VIC, Australia (S Graham MD); Department of Infection, Inflammation and Immunity, Institute of Child Health, University College London, London, UK (L Grandjean MD); Department of Information, National Institute of Public Health, Algiers, Algeria (D Hannoun MD); South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease & Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa (M Hatherill MD); Hesse State Health Office, Dillenburg, Germany (A M Hauri MD); University of Otago Medical School, Dunedin, New Zealand (P C Hill MD); Epicentre, Paris, France (H Huerga PhD); Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan (R Hussain MD); Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, CA, USA (L G Jarlsberg BA, M Kato-Maeda MD); Division of Infectious Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA (E C Jones-López MD); Research Institute of Tuberculosis, Tokyo, Japan (S Kato MD); The Vaccine Centre, London School of Hygiene & Tropical Medicine, London, UK (B Kampmann PhD); Department of Population Health Sciences, Geisinger, Danville, PA, USA (HL Kirchner PhD); Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (A Kritski PhD); Division of Clinical Infectious Diseases, Medical Clinic, Research Center Borstel, Borstel, Germany (C Lange MD); Respiratory Medicine & International Health, University of Lübeck, Lübeck, Germany (C Lange MD); Tuberculosis Unit, German Center for Infection Research, Borstel, Germany (C Lange MD); Department of Medicine, Karolinska Institute, Stockholm, Sweden (C Lange MD); Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan (C Lee MD); Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (C Lee MD); Department of Laboratory Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University, New Taipei City, Taiwan (L Lee MD); University Hospital Professor Edgard Santos, Federal University of Bahia, Salvador, Bahia, Brazil (A C Lemos MD, E N Netto PhD); Taichung Regional Center, Taiwan Centers for Disease Control, Taipei, Taiwan (D Ling MPH); Tuberculosis Program Evaluation and Research Unit, University of Alberta, Edmonton, AB, Canada (R Long MD); Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA (M J Magee PhD); Uganda-CWRU Research Collaboration, Makerere University and Mulago Hospital, Kampala, Uganda (L L Malone MSPH, W H Boom MD, C M Stein PhD); Division of Infectious Disease, Department of Medicine and Tuberculosis Research Unit, Case Western Reserve University, Cleveland, OH, USA (W H Boom MD, C M Stein PhD); University Hospitals Cleveland Medical Center, Cleveland, OH, USA (W H Boom MD, C M Stein PhD); The Global TB Program, Texas Children’s Hospital and the Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA (A M Mandalakas MD); Perinatal HIV Research Unit (PHRU), University of the Witwatersrand, Johannesburg, South Africa (N A Martinson MBBCH); Center for TB Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA (N A Martinson MBBCH); Department of Pediatrics, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India (R Mazahir MD); Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru (L Otero PhD); Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru (L Otero PhD); University of California, Berkeley, Berkeley, CA, USA (A Reingold MD); Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa (J A Seddon PhD, A C Hesseling MD, H S Schaaf MD); Department of Molecular Medicine, Jamia Hamdard Institute of Molecular Medicine, New Delhi, India (S Sharma MD); Departments of General Medicine and Respiratory, Medicine Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India (S Sharma MD); Department of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India (J Singh PhD); All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India (S Singh MD); Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy (G Sotgiu PhD); Departments of Paediatrics and Child Health, Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan (N T Iqbal PhD); Department of Pediatrics, Dr Sardjito Hospital and Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia (R Triasih PhD); Department of Public Health, Faculty of Medicine, Ghent University, Ghent, Belgium (P Van der Stuyft PhD); The South African Department of Science and Technology/National Research Foundation (DST/NRF) Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), University of Stellenbosch, Stellenbosch, South Africa (C van Schalkwyk MCom); Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India (R Vashishtha PhD); Laboratorio de Tuberculosis, Instituto de Biomedicina, Universidad Central de Venezuela, Caracas, Venezuela (L M Verhagen MD, J A Villalba MD); Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands (L M Verhagen MD); Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA (J A Villalba MD); Global Health Institute, University of Georgia, Athens, GA, USA (C C Whalen MD); Respiratory Disease Center, Fukujuji Hospital, Tokyo, Japan (T Yoshiyama MD); Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital and Medical Research Council Unit on Child and Adolescent Health, Cape Town, South Africa (H J Zar PhD); TB Competence Center, Swiss Lung Association, Berne, Switzerland (J P Zellweger MD); and Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, Jiangsu Province, China (L Zhu MD, Q Liu MD, P Lu PhD).National Institutes of HealthMúltipla - ver em NotasBackground: Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood. Methods: In this systematic review and meta-analysis, we investigated the development of tuberculosis in children closely exposed to a tuberculosis case and followed for incident disease. We restricted our search to cohort studies published between Jan 1, 1998, and April 6, 2018, in MEDLINE, Web of Science, BIOSIS, and Embase electronic databases. Individual-participant data and a pre-specified list of variables were requested from authors of all eligible studies. These included characteristics of the exposed child, the index case, and environmental characteristics. To be eligible for inclusion in the final analysis, a dataset needed to include: (1) individuals below 19 years of age; (2) followup for tuberculosis for a minimum of 6 months; (3) individuals with household or close exposure to an individual with tuberculosis; (4) information on the age and sex of the child; and (5) start and end follow-up dates. Studies assessing incident tuberculosis but without dates or time of follow-up were excluded. Our analysis had two primary aims: (1) estimating the risk of developing tuberculosis by time-period of follow-up, demographics (age, region), and clinical attributes (HIV, tuberculosis infection status, previous tuberculosis); and (2) estimating the effectiveness of preventive therapy and BCG vaccination on the risk of developing tuberculosis. We estimated the odds of prevalent tuberculosis with mixed-effects logistic models and estimated adjusted hazard ratios (HRs) for incident tuberculosis with mixedeffects Poisson regression models. The effectiveness of preventive therapy against incident tuberculosis was estimated through propensity score matching. The study protocol is registered with PROSPERO (CRD42018087022). Findings: In total, study groups from 46 cohort studies in 34 countries—29 (63%) prospective studies and 17 (37%) retrospective—agreed to share their data and were included in the final analysis. 137 647 tuberculosis-exposed children were evaluated at baseline and 130 512 children were followed for 429 538 person-years, during which 1299 prevalent and 999 incident tuberculosis cases were diagnosed. Children not receiving preventive therapy with a positive result for tuberculosis infection had significantly higher 2-year cumulative tuberculosis incidence than children with a negative result for tuberculosis infection, and this incidence was greatest among children below 5 years of age (19·0% [95% CI 8·4–37·4]). The effectiveness of preventive therapy was 63% (adjusted HR 0·37 [95% CI 0·30–0·47]) among all exposed children, and 91% (adjusted HR 0·09 [0·05–0·15]) among those with a positive result for tuberculosis infection. Among all children <5 years of age who developed tuberculosis, 83% were diagnosed within 90 days of the baseline visit. Interpretation: The risk of developing tuberculosis among exposed infants and young children is very high. Most cases occurred within weeks of contact investigation initiation and might not be preventable through prophylaxis. This suggests that alternative strategies for prevention are needed, such as earlier initiation of preventive therapy through rapid diagnosis of adult cases or community-wide screening approaches.engElsevierTuberculoseCriançasExposição próximaRevisão sistemáticaRiscosRisk of tuberculosisChildrenClose exposureSystematic reviewThe risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| title |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| spellingShingle |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis Martinez, Leonardo Tuberculose Crianças Exposição próxima Revisão sistemática Riscos Risk of tuberculosis Children Close exposure Systematic review |
| title_short |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| title_full |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| title_fullStr |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| title_full_unstemmed |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| title_sort |
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis |
| author |
Martinez, Leonardo |
| author_facet |
Martinez, Leonardo Cords, Olivia Acuna-Villaorduña, Carlos Ahuja, Shama Desai Altet, Neus Augusto, Orvalho Baliashvili, Davit Basu, Sanjay Becerra, Mercedes Bonnet, Maryline Boom, W. Henry Borgdorf, Martien Boulahbal, Fadila Carvalho, Anna Cristina Calçada Cayla, Joan A. Chakhaia, Tsira Cohen, Ted Pei-Chun, Chan Croda, Julio Henrique Rosa Datta, Sumona Corral, Helena del Denholm, Justin T. Dietze, Reynaldo Dobler, Claudia C. Donkor, Simon Egere, Uzochukwu Ellner, Jerrold J. Espinal, Marcos Evans, Carlton A. Chi-Tai, Fang Fielding, Katherine Fox, Greg J. García, Luis F. García-Basteiro, Alberto L. Geis, Steffen Graham, Stephen M. Grandjean, Louis Hannoun, Djohar Hatherill, Mark Hauri, Anja M. Hesseling, Anneke C. Hill, Philip C. Li-Min, Huang Huerga, Helena Hussain, Rabia Jarlsberg, Leah Jones-López, Edward C. Kato, Seiya Kato-Maeda, Midori Kampmann, Beate Kirchner, H. Lester Kritski, Afrânio Lange, Christoph Meng-Rui, Lee Li-Na, Lee Chih-Hsin, Lee Lemos, Antonio Carlos Lienhardt, Christian Du-Lin, Ling Qiao, Liu Lo, Nathan C. Long, Richard Lopez-Varela, Elisa Peng, Lu Magee, Matthew Malone, LaShaunda L. Mandalakas, Anna M. Martinson, Neil A. Mazahir, Rufaida Murray, Megan B. Martins Netto, Eduardo Otero, Larissa Parsonnet, Julie Reingold, Arthur Schaaf, H. Simon Seddon, James A. Sharma, Surendra Singh, Jitendra Singh, Sarman Sloot, Rosa Sotgiu, Giovanni Stein, Catherine M. Iqbal, Najeeha Talat Triasih, Rina Trieu, Lisa Loeff, Maarten F. Schim van der Stuyft, Patrick van der Schalkwyk, Cari van Vashishtha, Richa Verhagen, Lilly M. Villalba, Julian A. Jann-Yuan, Wang Whalen, Christopher C. Yoshiyama, Takashi Zar, Heather J. Zellweger, Jean-Pierre Limei, Zhu Horsburgh, C. Robert Andrews, Jason R. |
| author_role |
author |
| author2 |
Cords, Olivia Acuna-Villaorduña, Carlos Ahuja, Shama Desai Altet, Neus Augusto, Orvalho Baliashvili, Davit Basu, Sanjay Becerra, Mercedes Bonnet, Maryline Boom, W. Henry Borgdorf, Martien Boulahbal, Fadila Carvalho, Anna Cristina Calçada Cayla, Joan A. Chakhaia, Tsira Cohen, Ted Pei-Chun, Chan Croda, Julio Henrique Rosa Datta, Sumona Corral, Helena del Denholm, Justin T. Dietze, Reynaldo Dobler, Claudia C. Donkor, Simon Egere, Uzochukwu Ellner, Jerrold J. Espinal, Marcos Evans, Carlton A. Chi-Tai, Fang Fielding, Katherine Fox, Greg J. García, Luis F. García-Basteiro, Alberto L. Geis, Steffen Graham, Stephen M. Grandjean, Louis Hannoun, Djohar Hatherill, Mark Hauri, Anja M. Hesseling, Anneke C. Hill, Philip C. Li-Min, Huang Huerga, Helena Hussain, Rabia Jarlsberg, Leah Jones-López, Edward C. Kato, Seiya Kato-Maeda, Midori Kampmann, Beate Kirchner, H. Lester Kritski, Afrânio Lange, Christoph Meng-Rui, Lee Li-Na, Lee Chih-Hsin, Lee Lemos, Antonio Carlos Lienhardt, Christian Du-Lin, Ling Qiao, Liu Lo, Nathan C. Long, Richard Lopez-Varela, Elisa Peng, Lu Magee, Matthew Malone, LaShaunda L. Mandalakas, Anna M. Martinson, Neil A. Mazahir, Rufaida Murray, Megan B. Martins Netto, Eduardo Otero, Larissa Parsonnet, Julie Reingold, Arthur Schaaf, H. Simon Seddon, James A. Sharma, Surendra Singh, Jitendra Singh, Sarman Sloot, Rosa Sotgiu, Giovanni Stein, Catherine M. Iqbal, Najeeha Talat Triasih, Rina Trieu, Lisa Loeff, Maarten F. Schim van der Stuyft, Patrick van der Schalkwyk, Cari van Vashishtha, Richa Verhagen, Lilly M. Villalba, Julian A. Jann-Yuan, Wang Whalen, Christopher C. Yoshiyama, Takashi Zar, Heather J. Zellweger, Jean-Pierre Limei, Zhu Horsburgh, C. Robert Andrews, Jason R. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Martinez, Leonardo Cords, Olivia Acuna-Villaorduña, Carlos Ahuja, Shama Desai Altet, Neus Augusto, Orvalho Baliashvili, Davit Basu, Sanjay Becerra, Mercedes Bonnet, Maryline Boom, W. Henry Borgdorf, Martien Boulahbal, Fadila Carvalho, Anna Cristina Calçada Cayla, Joan A. Chakhaia, Tsira Cohen, Ted Pei-Chun, Chan Croda, Julio Henrique Rosa Datta, Sumona Corral, Helena del Denholm, Justin T. Dietze, Reynaldo Dobler, Claudia C. Donkor, Simon Egere, Uzochukwu Ellner, Jerrold J. Espinal, Marcos Evans, Carlton A. Chi-Tai, Fang Fielding, Katherine Fox, Greg J. García, Luis F. García-Basteiro, Alberto L. Geis, Steffen Graham, Stephen M. Grandjean, Louis Hannoun, Djohar Hatherill, Mark Hauri, Anja M. Hesseling, Anneke C. Hill, Philip C. Li-Min, Huang Huerga, Helena Hussain, Rabia Jarlsberg, Leah Jones-López, Edward C. Kato, Seiya Kato-Maeda, Midori Kampmann, Beate Kirchner, H. Lester Kritski, Afrânio Lange, Christoph Meng-Rui, Lee Li-Na, Lee Chih-Hsin, Lee Lemos, Antonio Carlos Lienhardt, Christian Du-Lin, Ling Qiao, Liu Lo, Nathan C. Long, Richard Lopez-Varela, Elisa Peng, Lu Magee, Matthew Malone, LaShaunda L. Mandalakas, Anna M. Martinson, Neil A. Mazahir, Rufaida Murray, Megan B. Martins Netto, Eduardo Otero, Larissa Parsonnet, Julie Reingold, Arthur Schaaf, H. Simon Seddon, James A. Sharma, Surendra Singh, Jitendra Singh, Sarman Sloot, Rosa Sotgiu, Giovanni Stein, Catherine M. Iqbal, Najeeha Talat Triasih, Rina Trieu, Lisa Loeff, Maarten F. Schim van der Stuyft, Patrick van der Schalkwyk, Cari van Vashishtha, Richa Verhagen, Lilly M. Villalba, Julian A. Jann-Yuan, Wang Whalen, Christopher C. Yoshiyama, Takashi Zar, Heather J. Zellweger, Jean-Pierre Limei, Zhu Horsburgh, C. Robert Andrews, Jason R. |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Crianças Exposição próxima Revisão sistemática Riscos |
| topic |
Tuberculose Crianças Exposição próxima Revisão sistemática Riscos Risk of tuberculosis Children Close exposure Systematic review |
| dc.subject.en.en.fl_str_mv |
Risk of tuberculosis Children Close exposure Systematic review |
| description |
Carvalho, Ana Cristina Calçada. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.; Croda, Julio Henrique Rosa. Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento. |
| publishDate |
2020 |
| dc.date.accessioned.fl_str_mv |
2020-08-12T12:20:49Z |
| dc.date.available.fl_str_mv |
2020-08-12T12:20:49Z |
| dc.date.issued.fl_str_mv |
2020 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
MARTINEZ, Leonardo et al. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis. The Lancet, v. 395, n. 10228, p. 973-984, 21 Mar. 2020. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/42701 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1474-547X |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1016/S0140-6736(20)30166-5 |
| identifier_str_mv |
MARTINEZ, Leonardo et al. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis. The Lancet, v. 395, n. 10228, p. 973-984, 21 Mar. 2020. 1474-547X 10.1016/S0140-6736(20)30166-5 |
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Elsevier |
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Elsevier |
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