Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents

Detalhes bibliográficos
Autor(a) principal: Siqueira Filho, Ezequias Pessoa de
Data de Publicação: 2016
Outros Autores: Ramos, Zani, Carlos Leomar, Nogueira, Albina Carvalho de Oliveira, Nelson, David Lee, Souza-Fagundes, Elaine Maria de, Cota, Betania Barros
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54095
Resumo: FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS
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spelling Siqueira Filho, Ezequias Pessoa deRamosZani, Carlos LeomarNogueira, Albina Carvalho de OliveiraNelson, David LeeSouza-Fagundes, Elaine Maria deCota, Betania Barros2022-08-01T13:20:18Z2022-08-01T13:20:18Z2016SIQUEIRA FILHO, Ezequias Pessoa de. Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents. Natural Products Chemistry & Research, v. 04, n. 02, 1000204, 2016. DOI:10.4172/2329-6836.10002042329-6836https://www.arca.fiocruz.br/handle/icict/5409510.4172/2329-6836.1000204FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISLaboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, BrazilDepartment of Physiology and Biophysics. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, BrazilZoo-Botanic Foundation of Belo Horizonte. Belo Horizonte, MG, BrazilPro-Rectory of Graduate and Research Program. Federal University of Jequitinhonha and Mucuri Valley. Diamantina, MG, BrazilDepartment of Physiology and Biophysics. Federal University of Minas Gerais. Belo Horizonte, MG, BrazilLaboratory of Chemistry and Natural Products. René Rachou Research Center. Oswaldo Cruz Foundation. Belo Horizonte, MG, BrazilCytotoxicity activities of the crude ethanol extracts from Chamaecostus subsessilis and Chamaecostus cuspidatus and the fractions obtained by liquid-liquid partition were observed when these species were assayed against a panel of six human cancer cell lineages (HL60, Jurkat, MDA-MB231, MCF-7, HCT, THP-1) and normal (Vero) cells using the MTT colorimetric assay. The cytotoxic effects in the HL60, Jurkat and THP-1 lineages were mediated via an apoptotic mechanism when treated with crude ethanol extracts from these species. The presence of flavonoids, terpenoids and saponins in fractions from both species was observed in the preliminary phytochemical study. These results provide scientific support for the study of the Costaceae family and show that C. cuspidatus and C. subsessilis are potential sources of compounds with anticancer activities.engInternational Online Medical CouncilChamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNatural productsChamaecostus; CancerAntitumoral agentsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/54095/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALChamaecostus subsessilis and Chamaecost...Potential Sources of Anticancer Agents.pdfChamaecostus subsessilis and Chamaecost...Potential Sources of Anticancer Agents.pdfapplication/pdf360787https://www.arca.fiocruz.br/bitstream/icict/54095/2/Chamaecostus%20subsessilis%20and%20Chamaecost...Potential%20Sources%20of%20Anticancer%20Agents.pdf87850f5a3659331c623223dd0e7f6134MD52icict/540952022-08-01 10:20:18.326oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-01T13:20:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
title Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
spellingShingle Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
Siqueira Filho, Ezequias Pessoa de
Natural products
Chamaecostus; Cancer
Antitumoral agents
title_short Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
title_full Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
title_fullStr Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
title_full_unstemmed Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
title_sort Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents
author Siqueira Filho, Ezequias Pessoa de
author_facet Siqueira Filho, Ezequias Pessoa de
Ramos
Zani, Carlos Leomar
Nogueira, Albina Carvalho de Oliveira
Nelson, David Lee
Souza-Fagundes, Elaine Maria de
Cota, Betania Barros
author_role author
author2 Ramos
Zani, Carlos Leomar
Nogueira, Albina Carvalho de Oliveira
Nelson, David Lee
Souza-Fagundes, Elaine Maria de
Cota, Betania Barros
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Siqueira Filho, Ezequias Pessoa de
Ramos
Zani, Carlos Leomar
Nogueira, Albina Carvalho de Oliveira
Nelson, David Lee
Souza-Fagundes, Elaine Maria de
Cota, Betania Barros
dc.subject.en.pt_BR.fl_str_mv Natural products
Chamaecostus; Cancer
Antitumoral agents
topic Natural products
Chamaecostus; Cancer
Antitumoral agents
description FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2022-08-01T13:20:18Z
dc.date.available.fl_str_mv 2022-08-01T13:20:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SIQUEIRA FILHO, Ezequias Pessoa de. Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents. Natural Products Chemistry & Research, v. 04, n. 02, 1000204, 2016. DOI:10.4172/2329-6836.1000204
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54095
dc.identifier.issn.pt_BR.fl_str_mv 2329-6836
dc.identifier.doi.none.fl_str_mv 10.4172/2329-6836.1000204
identifier_str_mv SIQUEIRA FILHO, Ezequias Pessoa de. Chamaecostus subsessilis and Chamaecostus cuspidatus (Nees & Mart) C.Specht and D.W.Stev as Potential Sources of Anticancer Agents. Natural Products Chemistry & Research, v. 04, n. 02, 1000204, 2016. DOI:10.4172/2329-6836.1000204
2329-6836
10.4172/2329-6836.1000204
url https://www.arca.fiocruz.br/handle/icict/54095
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv International Online Medical Council
publisher.none.fl_str_mv International Online Medical Council
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/54095/1/license.txt
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