Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/18656 |
Resumo: | Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil. |
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Marques, André M.Velozo, Leosvaldo S.Carvalho, Michelle A.Serdeiro, Michele T.Honório, Nildimar A.Kaplan, Maria Auxiliadora C.Maleck, Marise2017-04-25T15:43:34Z2017-04-25T15:43:34Z2017MARQUES, André M. et al. Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil. J. Vector Borne Dis., v.54, p.61-68, Mar. 2017.0972-9062https://www.arca.fiocruz.br/handle/icict/18656engMedknow PubicationsDengueAedes aegyptiAtividade larvicidaBrasil1-butyl-34-methylenedioxybenzeneAedes aegyptidenguelarvicidal activityOttonia anisumPiperBrazilLarvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Severino Sombra. Laboratório de Insetos Vetores. Vassouras, RJ, Brasil.Universidade Severino Sombra. Laboratório de Insetos Vetores. Vassouras, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Vigilância Entomológica em Diptera e Hemiptera. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio e Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Núcleo Operacional Sentinela de Mosquitos Vetores. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil.Universidade Severino Sombra. Laboratório de Insetos Vetores. Vassouras, RJ, Brasil / Universidade Severino Sombra. Curso de Mestrado Profissional em Ciências Ambientais. Curso de Mestrado Profissional em Ciências da Saúde. Vassouras, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Entomologia Médica e Forense. Rio de Janeiro, RJ, Brasil.Background & objectives: Aedes aegypti mosquito is the principal vector of the viruses responsible for urban yellow fever, dengue, dengue haemorrhagic fever, as well as Zika and chikungunya in Brazil. The present study was aimed to investigate the insecticidal potential of the extract and fractions of Ottonia anisum, along with special metabolites isolated from it, as natural alternatives against larvae (L3) of Ae. aegypti, vector of potentially deadly tropical infections in Brazil. Methods: The plant species O. anisum was collected in March 2015, at Xerém area, in Rio de Janeiro City, Brazil. Crude extracts and the isolated pure compounds were screened for toxicity against Ae. aegypti larvae (L3). Bioassays were performed on 20 larvae (L3) of Ae. aegypti in triplicate. The samples were dissolved in a mixture of acetone and DMSO at final concentrations of 1–200 μg/ml. The toxicity of the solutions was evaluated towards the growth and development of Ae. aegypti larvae till emergence of adults. Results: The crude hexane extract showed 100% larval mortality 24 h after treatment at a concentration of 200 μg/ ml. The bioassays using 1-butyl-3,4-methylenedioxybenzene revealed 100% mortality among L3 larvae, 24 h after the treatment at a concentration of 30 μg/ml, the LC50 recorded was 1.6 μg/ml. At concentration of 10 μg/ml, the L3 larval mortality recorded was 92%. Interpretation & conclusion: The metabolite 1-butyl-3,4-methylenedioxybenzene showed potent toxicity against Ae. aegypti larvae. This arylbutanoid agent could be used as a natural alternative adjuvant pesticide, in new compositions that would be environmentally safer.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/18656/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALnildimar_honorio_etal_IOC_2017.pdfnildimar_honorio_etal_IOC_2017.pdfapplication/pdf285283https://www.arca.fiocruz.br/bitstream/icict/18656/2/nildimar_honorio_etal_IOC_2017.pdf258d00de4d51d5f0c1878a247188f7b5MD52TEXTnildimar_honorio_etal_IOC_2017.pdf.txtnildimar_honorio_etal_IOC_2017.pdf.txtExtracted texttext/plain37775https://www.arca.fiocruz.br/bitstream/icict/18656/3/nildimar_honorio_etal_IOC_2017.pdf.txt7d6e10ce50edabbce4b225bcb5614687MD53icict/186562023-09-05 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| dc.title.pt_BR.fl_str_mv |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| title |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| spellingShingle |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil Marques, André M. Dengue Aedes aegypti Atividade larvicida Brasil 1-butyl-3 4-methylenedioxybenzene Aedes aegypti dengue larvicidal activity Ottonia anisum Piper Brazil |
| title_short |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| title_full |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| title_fullStr |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| title_full_unstemmed |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| title_sort |
Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil |
| author |
Marques, André M. |
| author_facet |
Marques, André M. Velozo, Leosvaldo S. Carvalho, Michelle A. Serdeiro, Michele T. Honório, Nildimar A. Kaplan, Maria Auxiliadora C. Maleck, Marise |
| author_role |
author |
| author2 |
Velozo, Leosvaldo S. Carvalho, Michelle A. Serdeiro, Michele T. Honório, Nildimar A. Kaplan, Maria Auxiliadora C. Maleck, Marise |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Marques, André M. Velozo, Leosvaldo S. Carvalho, Michelle A. Serdeiro, Michele T. Honório, Nildimar A. Kaplan, Maria Auxiliadora C. Maleck, Marise |
| dc.subject.other.pt_BR.fl_str_mv |
Dengue Aedes aegypti Atividade larvicida Brasil |
| topic |
Dengue Aedes aegypti Atividade larvicida Brasil 1-butyl-3 4-methylenedioxybenzene Aedes aegypti dengue larvicidal activity Ottonia anisum Piper Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
1-butyl-3 4-methylenedioxybenzene Aedes aegypti dengue larvicidal activity Ottonia anisum Piper Brazil |
| description |
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto Walter Mors de Pesquisa em Produtos Naturais. Rio de Janeiro, RJ, Brasil. |
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2017 |
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2017-04-25T15:43:34Z |
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2017-04-25T15:43:34Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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MARQUES, André M. et al. Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil. J. Vector Borne Dis., v.54, p.61-68, Mar. 2017. |
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https://www.arca.fiocruz.br/handle/icict/18656 |
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0972-9062 |
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MARQUES, André M. et al. Larvicidal activity of Ottonia anisum metabolites against Aedes aegypti: A potential natural alternative source for mosquito vector control in Brazil. J. Vector Borne Dis., v.54, p.61-68, Mar. 2017. 0972-9062 |
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Medknow Pubications |
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