HDAC8: a multifaceted target for therapeutic interventions.

Detalhes bibliográficos
Autor(a) principal: Chakrabarti, Alokta
Data de Publicação: 2015
Outros Autores: Oehme, Ina, Witt, Olaf, Oliveira, Guilherme Correa de, Sippl, Wolfgang, Romier, Christophe, Pierce, Raymond John, Jung, Manfred
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12712
Resumo: Albert-Ludwigs-Universität Freiburg. Institute of Pharmaceutical Sciences. Freiburg, Germany
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spelling Chakrabarti, AloktaOehme, InaWitt, OlafOliveira, Guilherme Correa deSippl, WolfgangRomier, ChristophePierce, Raymond JohnJung, Manfred2016-02-11T12:39:04Z2016-02-11T12:39:04Z2015CHAKRABARTI, Alokta et al. HDAC8: a multifaceted target for therapeutic interventions. Trends Pharmacol Sci., vol. 36, n. 7, p. 481-492, 2015.0165-6147https://www.arca.fiocruz.br/handle/icict/1271210.1016/j.tips.2015.04.013engElsevier IncHDAC8: a multifaceted target for therapeutic interventions.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAlbert-Ludwigs-Universität Freiburg. Institute of Pharmaceutical Sciences. Freiburg, GermanyGerman Cancer Research Centre. Clinical Cooperation Unit Pediatric Oncology. Heidelberg, GermanyGerman Cancer Research Centre. Clinical Cooperation Unit Pediatric Oncology. Heidelberg, Germany/University Hospital Heidelberg. Department of Pediatric Oncology, Hematology and Immunology. Heidelberg, GermanyFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Genômica e Biologia Computacional. Belo Horizonte, MG, BrazilMartin-Luther-Universität Halle-Wittenberg. Institut für Pharmazie. Halle, GermanyUniversité de Strasbourg. Institut de Génétique et Biologie Moléculaire et Cellulaire. Département de Biologie Structurale Intégrative. Illkirch, FranceInstitut Pasteur de Lille. Université de Lille. Center for Infection and Immunity of Lille. Lille, FranceAlbert-Ludwigs-Universität Freiburg. Institute of Pharmaceutical Sciences. Freiburg, GermanyHistone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and parasitic infections. It is a structurally well-characterized enzyme that also deacetylates nonhistone proteins. In cancer, HDAC8 is a major ‘epigenetic player’ that is linked to deregulated expression or interaction with transcription factors critical to tumorigenesis. In the parasite Schistosoma mansoni and in viral infections, HDAC8 is a novel target to subdue infection. The current challenge remains in the development of potent selective inhibitors that would specifically target HDAC8 with fewer adverse effects compared with pan-HDAC inhibitors. Here, we review HDAC8 as a drug target and discuss inhibitors with respect to their structural features and therapeutic interventions.histone deacetylasesHDAC8Cornelia de Lange syndromecancerschistosomaX-ray crystallographyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12712/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALHDAC8.pdfHDAC8.pdfapplication/pdf660548https://www.arca.fiocruz.br/bitstream/icict/12712/2/HDAC8.pdfd2bbf10d487ae406bd049065445975aeMD52TEXTHDAC8.pdf.txtHDAC8.pdf.txtExtracted texttext/plain59844https://www.arca.fiocruz.br/bitstream/icict/12712/3/HDAC8.pdf.txt77ce406c41d924b6eca144e92819cc00MD53icict/127122022-02-01 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dc.title.pt_BR.fl_str_mv HDAC8: a multifaceted target for therapeutic interventions.
title HDAC8: a multifaceted target for therapeutic interventions.
spellingShingle HDAC8: a multifaceted target for therapeutic interventions.
Chakrabarti, Alokta
histone deacetylases
HDAC8
Cornelia de Lange syndrome
cancer
schistosoma
X-ray crystallography
title_short HDAC8: a multifaceted target for therapeutic interventions.
title_full HDAC8: a multifaceted target for therapeutic interventions.
title_fullStr HDAC8: a multifaceted target for therapeutic interventions.
title_full_unstemmed HDAC8: a multifaceted target for therapeutic interventions.
title_sort HDAC8: a multifaceted target for therapeutic interventions.
author Chakrabarti, Alokta
author_facet Chakrabarti, Alokta
Oehme, Ina
Witt, Olaf
Oliveira, Guilherme Correa de
Sippl, Wolfgang
Romier, Christophe
Pierce, Raymond John
Jung, Manfred
author_role author
author2 Oehme, Ina
Witt, Olaf
Oliveira, Guilherme Correa de
Sippl, Wolfgang
Romier, Christophe
Pierce, Raymond John
Jung, Manfred
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chakrabarti, Alokta
Oehme, Ina
Witt, Olaf
Oliveira, Guilherme Correa de
Sippl, Wolfgang
Romier, Christophe
Pierce, Raymond John
Jung, Manfred
dc.subject.en.pt_BR.fl_str_mv histone deacetylases
HDAC8
Cornelia de Lange syndrome
cancer
schistosoma
X-ray crystallography
topic histone deacetylases
HDAC8
Cornelia de Lange syndrome
cancer
schistosoma
X-ray crystallography
description Albert-Ludwigs-Universität Freiburg. Institute of Pharmaceutical Sciences. Freiburg, Germany
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-02-11T12:39:04Z
dc.date.available.fl_str_mv 2016-02-11T12:39:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHAKRABARTI, Alokta et al. HDAC8: a multifaceted target for therapeutic interventions. Trends Pharmacol Sci., vol. 36, n. 7, p. 481-492, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12712
dc.identifier.issn.none.fl_str_mv 0165-6147
dc.identifier.doi.none.fl_str_mv 10.1016/j.tips.2015.04.013
identifier_str_mv CHAKRABARTI, Alokta et al. HDAC8: a multifaceted target for therapeutic interventions. Trends Pharmacol Sci., vol. 36, n. 7, p. 481-492, 2015.
0165-6147
10.1016/j.tips.2015.04.013
url https://www.arca.fiocruz.br/handle/icict/12712
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/12712/1/license.txt
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