Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups

Detalhes bibliográficos
Autor(a) principal: Hiragi, Cássia de Oliveira
Data de Publicação: 2011
Outros Autores: Vilela, Ana Luisa Miranda, Rocha, Dulce Maria Sucena, Oliveira, Silviene Fabiana de, Hatagima, Ana, Guimarães, Nazaré Klautau
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16751
Resumo: Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.
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spelling Hiragi, Cássia de OliveiraVilela, Ana Luisa MirandaRocha, Dulce Maria SucenaOliveira, Silviene Fabiana deHatagima, AnaGuimarães, Nazaré Klautau2017-01-06T15:12:55Z2017-01-06T15:12:55Z2011HIRAGI, Cássia de Oliveira; et al. Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups. Genetics and Molecular Biology, v.34, n.1, p.11-18, 2011.1415-4757https://www.arca.fiocruz.br/handle/icict/167511415-4757engSociedade Brasileira de GenéticaAntioxidantesPolimorfismos gênicosEtnias brasileirasGenética populacionalFarmacogenéticaantioxidantsPCR-RFLPgene polymorphismsBrazilian ethnicitiespupolution geneticspharmacogeneticsSuperoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groupsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.Universidade de Brasília. Campus de Planaltina. Brasília, DF, Brasil.Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Genética. Rio de Janeiro, RJ, Brasil.Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.Antioxidants such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX1) reduce the oxidation rates in the organism. Gluthatione S-transferases (GSTs) play a vital role in phase 2 of biotransformation of many substances. Variation in the expression of these enzymes suggests individual differences for the degree of antioxidant protection and geographical differences in the distribution of these variants. We described the distribution frequency of CAT (21A/T), SOD2 (Ala9Val), GPX1 (Pro198Leu), GSTM1 and GSTT1 polymorphisms in three Brazilian population groups: Kayabi Amerindians (n = 60), Kalunga Afro-descendants (n = 72), and an urban mixed population from Federal District (n = 162). Frequencies of the variants observed in Kalunga (18% to 58%) and Federal District (33% to 63%) were similar to those observed in Euro and Afro-descendants, while in Kayabi (3% to 68%), depending on the marker, frequencies were similar to the ones found in different ethnic groups. Except for SOD2 in all population groups studied here, and for GPX1 in Kalunga, the genotypic distributions were in accordance with Hardy-Weinberg Equilibrium. These data can clarify the contribution of different ethnicities in the formation of mixed populations, such as that of Brazil. Moreover, outcomes will be valuable resources for future functional studies and for genetic studies in specific populations. If these studies are designed to comprehensively explore the role of these genetic polymorphisms in the etiology of human diseases they may help to prevent inconsistent genotype-phenotype associations in pharmacogenetic studies.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16751/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALana_hatagima_etal_IOC_2011.pdfana_hatagima_etal_IOC_2011.pdfapplication/pdf86925https://www.arca.fiocruz.br/bitstream/icict/16751/2/ana_hatagima_etal_IOC_2011.pdf6fd262116fda3b5f4f6e7397a46adf2eMD52TEXTana_hatagima_etal_IOC_2011.pdf.txtana_hatagima_etal_IOC_2011.pdf.txtExtracted texttext/plain40022https://www.arca.fiocruz.br/bitstream/icict/16751/3/ana_hatagima_etal_IOC_2011.pdf.txt4df390aeba5b1055a9c5f290c428ba55MD53icict/167512018-08-15 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dc.title.pt_BR.fl_str_mv Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
title Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
spellingShingle Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
Hiragi, Cássia de Oliveira
Antioxidantes
Polimorfismos gênicos
Etnias brasileiras
Genética populacional
Farmacogenética
antioxidants
PCR-RFLP
gene polymorphisms
Brazilian ethnicities
pupolution genetics
pharmacogenetics
title_short Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
title_full Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
title_fullStr Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
title_full_unstemmed Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
title_sort Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups
author Hiragi, Cássia de Oliveira
author_facet Hiragi, Cássia de Oliveira
Vilela, Ana Luisa Miranda
Rocha, Dulce Maria Sucena
Oliveira, Silviene Fabiana de
Hatagima, Ana
Guimarães, Nazaré Klautau
author_role author
author2 Vilela, Ana Luisa Miranda
Rocha, Dulce Maria Sucena
Oliveira, Silviene Fabiana de
Hatagima, Ana
Guimarães, Nazaré Klautau
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Hiragi, Cássia de Oliveira
Vilela, Ana Luisa Miranda
Rocha, Dulce Maria Sucena
Oliveira, Silviene Fabiana de
Hatagima, Ana
Guimarães, Nazaré Klautau
dc.subject.other.pt_BR.fl_str_mv Antioxidantes
Polimorfismos gênicos
Etnias brasileiras
Genética populacional
Farmacogenética
topic Antioxidantes
Polimorfismos gênicos
Etnias brasileiras
Genética populacional
Farmacogenética
antioxidants
PCR-RFLP
gene polymorphisms
Brazilian ethnicities
pupolution genetics
pharmacogenetics
dc.subject.en.pt_BR.fl_str_mv antioxidants
PCR-RFLP
gene polymorphisms
Brazilian ethnicities
pupolution genetics
pharmacogenetics
description Universidade de Brasília. Instituto de Ciências Biológicas. Departamento de Genética e Morfologia. Brasília, DF, Brasil.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2017-01-06T15:12:55Z
dc.date.available.fl_str_mv 2017-01-06T15:12:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HIRAGI, Cássia de Oliveira; et al. Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups. Genetics and Molecular Biology, v.34, n.1, p.11-18, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16751
dc.identifier.issn.pt_BR.fl_str_mv 1415-4757
dc.identifier.eissn.none.fl_str_mv 1415-4757
identifier_str_mv HIRAGI, Cássia de Oliveira; et al. Superoxide dismutase, catalase, glutathione peroxidase and gluthatione S-transferases M1 and T1 gene polymorphisms in three Brazilian population groups. Genetics and Molecular Biology, v.34, n.1, p.11-18, 2011.
1415-4757
url https://www.arca.fiocruz.br/handle/icict/16751
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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