Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60191 https://doi.org/10.1016/j.chemosphere.2023.139216 |
Resumo: | Universidade Federal do Paraná. Programa de Pós-Graduação em Ecologia e Conservação. Curitiba, PR, Brasil. |
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Carvalho, Lucicleide Ângelo Silva JunglesOya-Silva, Laís FernandaPerussolo, Maiara CarolinaGuaita, Gisele OliveiraBrito, Júlio César MoreiraEvans, Allan ArnoldProdocimo, Maritana MelaCestari, Marta MargareteBraga, Tarcio TeodoroAssis, Helena Cristina Silva de2023-08-22T15:49:56Z2023-08-22T15:49:56Z2023CARVALHO, Lucicleide Ângelo Silva Jungles et al. Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen. Chemosphere, v. 336, n. 139216, p. 1-13, 2023.0045-6535https://www.arca.fiocruz.br/handle/icict/60191https://doi.org/10.1016/j.chemosphere.2023.139216porElsevierFluorquinoloneAntibiotic ProphylaxisBiomarkersCiprofloxacinGenotoxicityFishesProfilaxis AntibióticaBiomarcadoresCiprofloxacinaGenotoxicidadPecesAntibioprophylaxieMarqueurs biologiquesCiprofloxacineGénotoxicitéPoissonsAntibioticoprofilaxiaBiomarcadoresCiprofloxacinaGenotoxicidadePeixesExperimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia queleninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Programa de Pós-Graduação em Ecologia e Conservação. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.Instituto de Pesquisa Pelé Pequeno Príncipe. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil.Fundação Ezequiel Dias. Belo Horizonte, MG, Brasil.Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil. / Faculdades Pequeno Príncipe. Faculdade de Medicina. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Biologia Celular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Genética. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Patologia. Curitiba, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil.Universidade Federal do Paraná. Programa de Pós-Graduação em Ecologia e Conservação. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Departamento de Farmacologia. Curitiba, PR, Brasil.Ciprofloxacin (CIP) is an antibiotic commonly used in human and veterinary medicine. It is present in the aquatic environment, but we still know very little about its effect on non-targeted organisms. This study aimed to evaluate the effects of long-term exposure to environmental CIP concentrations (1, 10, and 100 μg.L 1) in males and females of Rhamdia quelen. After 28 days of exposure, we collected the blood for the analysis of hematological and genotoxic biomarkers. Additionally, we measured 17 β-estradiol and 11 keto-testosterone levels. After the euthanasia, we collected the brain and the hypothalamus to analyze acetylcholinesterase (AChE) activity and neurotransmitters, respectively. The liver and gonads were assessed for biochemical, genotoxic, and histopathological biomarkers. At 100 μg.L 1 CIP, we observed genotoxicity in the blood, nuclear morphological changes, apoptosis, leukopenia, and a reduction of AChE in the brain. In the liver was observed oxidative stress and apoptosis. At 10 μg.L 1 CIP, leukopenia, morphological changes, and apoptosis were presented in the blood and a reduction of AChE in the brain. Apoptosis, leukocyte infiltration, steatosis, and necrosis occurred in the liver. Even at the lowest concentration (1 μg.L 1), adverse effects such as erythrocyte and liver genotoxicity, hepatocyte apoptosis, oxidative stress, and a decrease in somatic indexes were observed. The results showed the importance of monitoring CIP concentrations in the aquatic environment that cause sublethal effects on fish.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL1-s2.0-S004565Chemosphere.pdf1-s2.0-S004565Chemosphere.pdfapplication/pdf5729150https://www.arca.fiocruz.br/bitstream/icict/60191/2/1-s2.0-S004565Chemosphere.pdf271da245422558d8e3b1b9f5a78fc1b0MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60191/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/601912023-08-22 12:49:57.631oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-08-22T15:49:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| title |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| spellingShingle |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen Carvalho, Lucicleide Ângelo Silva Jungles Fluorquinolone Antibiotic Prophylaxis Biomarkers Ciprofloxacin Genotoxicity Fishes Profilaxis Antibiótica Biomarcadores Ciprofloxacina Genotoxicidad Peces Antibioprophylaxie Marqueurs biologiques Ciprofloxacine Génotoxicité Poissons Antibioticoprofilaxia Biomarcadores Ciprofloxacina Genotoxicidade Peixes |
| title_short |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| title_full |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| title_fullStr |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| title_full_unstemmed |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| title_sort |
Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen |
| author |
Carvalho, Lucicleide Ângelo Silva Jungles |
| author_facet |
Carvalho, Lucicleide Ângelo Silva Jungles Oya-Silva, Laís Fernanda Perussolo, Maiara Carolina Guaita, Gisele Oliveira Brito, Júlio César Moreira Evans, Allan Arnold Prodocimo, Maritana Mela Cestari, Marta Margarete Braga, Tarcio Teodoro Assis, Helena Cristina Silva de |
| author_role |
author |
| author2 |
Oya-Silva, Laís Fernanda Perussolo, Maiara Carolina Guaita, Gisele Oliveira Brito, Júlio César Moreira Evans, Allan Arnold Prodocimo, Maritana Mela Cestari, Marta Margarete Braga, Tarcio Teodoro Assis, Helena Cristina Silva de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carvalho, Lucicleide Ângelo Silva Jungles Oya-Silva, Laís Fernanda Perussolo, Maiara Carolina Guaita, Gisele Oliveira Brito, Júlio César Moreira Evans, Allan Arnold Prodocimo, Maritana Mela Cestari, Marta Margarete Braga, Tarcio Teodoro Assis, Helena Cristina Silva de |
| dc.subject.other.en_US.fl_str_mv |
Fluorquinolone |
| topic |
Fluorquinolone Antibiotic Prophylaxis Biomarkers Ciprofloxacin Genotoxicity Fishes Profilaxis Antibiótica Biomarcadores Ciprofloxacina Genotoxicidad Peces Antibioprophylaxie Marqueurs biologiques Ciprofloxacine Génotoxicité Poissons Antibioticoprofilaxia Biomarcadores Ciprofloxacina Genotoxicidade Peixes |
| dc.subject.en.en_US.fl_str_mv |
Antibiotic Prophylaxis Biomarkers Ciprofloxacin Genotoxicity Fishes |
| dc.subject.es.en_US.fl_str_mv |
Profilaxis Antibiótica Biomarcadores Ciprofloxacina Genotoxicidad Peces |
| dc.subject.fr.en_US.fl_str_mv |
Antibioprophylaxie Marqueurs biologiques Ciprofloxacine Génotoxicité Poissons |
| dc.subject.decs.en_US.fl_str_mv |
Antibioticoprofilaxia Biomarcadores Ciprofloxacina Genotoxicidade Peixes |
| description |
Universidade Federal do Paraná. Programa de Pós-Graduação em Ecologia e Conservação. Curitiba, PR, Brasil. |
| publishDate |
2023 |
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2023-08-22T15:49:56Z |
| dc.date.available.fl_str_mv |
2023-08-22T15:49:56Z |
| dc.date.issued.fl_str_mv |
2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
CARVALHO, Lucicleide Ângelo Silva Jungles et al. Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen. Chemosphere, v. 336, n. 139216, p. 1-13, 2023. |
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https://www.arca.fiocruz.br/handle/icict/60191 |
| dc.identifier.issn.en_US.fl_str_mv |
0045-6535 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.chemosphere.2023.139216 |
| identifier_str_mv |
CARVALHO, Lucicleide Ângelo Silva Jungles et al. Experimentally exposed toxic effects of long-term exposure to environmentally relevant concentrations of CIP in males and females of the silver catfish Rhamdia quelen. Chemosphere, v. 336, n. 139216, p. 1-13, 2023. 0045-6535 |
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https://www.arca.fiocruz.br/handle/icict/60191 https://doi.org/10.1016/j.chemosphere.2023.139216 |
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Elsevier |
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Elsevier |
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