Effects of azadirachtin in Rhodnius prolixus: data and hypotheses

Detalhes bibliográficos
Autor(a) principal: Garcia, E. S.
Data de Publicação: 1991
Outros Autores: Gonzales, M. S., Azambuja, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1590/S0074-02761991000600025
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43465
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Garcia, E. S.Gonzales, M. S.Azambuja, Patricia2020-09-18T19:46:57Z2020-09-18T19:46:57Z1991GARCIA, E. S.; GONZALES, M. S.; AZAMBUJA, P. Effects of azadirachtin in Rhodnius prolixus: data and hypotheses. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl. 2, p. 107-111, 1991.0074-0276https://www.arca.fiocruz.br/handle/icict/4346510.1590/S0074-027619910006000251678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Rhodnius prolixusAzadiractinaTrypanosoma cruziRhodnius prolixusazadirachtinTrypanosoma cruziEffects of azadirachtin in Rhodnius prolixus: data and hypothesesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Biologia Geral. Niterói, RJ, Brasil.The effects of azadirachtin A, a tetranortriterpenoid from the neem tree Azadirachta indica J., on both development and interaction between Trypanosoma cruzi, the causative agent of Chagas' disease, and its vector Rhodnius prolixus were studied. Given through a blood meal, a dose-rsponse relationship of azadirachtin was established using antifeedant effect and ecdysis inhibition as effective parameters. A singlo dose of azadirachtin A was able to block the onset of mitosis in the epidermis and ecdysteroid titers in the hemnolymph, determined by radioimmuneassay, were too low for an induction of ecadysis. The survival of T. cruzi was also studied in R. prolixus treated with the drug. If the trypomastigotes were fed in presence of azadirachtin A the number of parasites drastically decreased. If the drug was applied after infection of the bug with T. cruzi, the parasite was still abolished from the gut. If the insect was pretreated with azadirachtin A before infection the same observation was obtained. A single dose of azadirachtin A was enough for a permanent resistance of the insect host against its reinfection with T. cruzi and for blocking the ecdysis for a long time. The effects of azadirachtin A on the hormonal balance of the host and growth inhibition of the parasite will be discussed on the basis of the present results.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43465/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALESGarcia_etal_IOC_1991.pdfESGarcia_etal_IOC_1991.pdfapplication/pdf297248https://www.arca.fiocruz.br/bitstream/icict/43465/2/ESGarcia_etal_IOC_1991.pdf8a30a908b10fe4452ef57abef5618181MD52TEXTESGarcia_etal_IOC_1991.pdf.txtESGarcia_etal_IOC_1991.pdf.txtExtracted texttext/plain5https://www.arca.fiocruz.br/bitstream/icict/43465/3/ESGarcia_etal_IOC_1991.pdf.txtcc9067c2ee470dc248b14b194209a34eMD53icict/434652020-09-19 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dc.title.pt_BR.fl_str_mv Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
title Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
spellingShingle Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
Garcia, E. S.
Rhodnius prolixus
Azadiractina
Trypanosoma cruzi
Rhodnius prolixus
azadirachtin
Trypanosoma cruzi
title_short Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
title_full Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
title_fullStr Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
title_full_unstemmed Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
title_sort Effects of azadirachtin in Rhodnius prolixus: data and hypotheses
author Garcia, E. S.
author_facet Garcia, E. S.
Gonzales, M. S.
Azambuja, Patricia
author_role author
author2 Gonzales, M. S.
Azambuja, Patricia
author2_role author
author
dc.contributor.author.fl_str_mv Garcia, E. S.
Gonzales, M. S.
Azambuja, Patricia
dc.subject.other.pt_BR.fl_str_mv Rhodnius prolixus
Azadiractina
Trypanosoma cruzi
topic Rhodnius prolixus
Azadiractina
Trypanosoma cruzi
Rhodnius prolixus
azadirachtin
Trypanosoma cruzi
dc.subject.en.pt_BR.fl_str_mv Rhodnius prolixus
azadirachtin
Trypanosoma cruzi
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bioquímica e Biologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 1991
dc.date.issued.fl_str_mv 1991
dc.date.accessioned.fl_str_mv 2020-09-18T19:46:57Z
dc.date.available.fl_str_mv 2020-09-18T19:46:57Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GARCIA, E. S.; GONZALES, M. S.; AZAMBUJA, P. Effects of azadirachtin in Rhodnius prolixus: data and hypotheses. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl. 2, p. 107-111, 1991.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43465
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761991000600025
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv GARCIA, E. S.; GONZALES, M. S.; AZAMBUJA, P. Effects of azadirachtin in Rhodnius prolixus: data and hypotheses. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 86, Suppl. 2, p. 107-111, 1991.
0074-0276
10.1590/S0074-02761991000600025
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43465
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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