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spelling Dória, Grace Anne AzevedoMenezes, Paula dos PassosLima, Bruno dos SantosVasconcelos, Bruno SSilva, Francilene Amaral daHenriques, Raíssa MeloMelo, Marcélia Garcez Dória deAlves, Ângela Valéria FariasMoraes, Manoel OPessoa, Cláudia do ÓCarvalho, Adriana AndradePrata, Ana Paula do NascimentoAlbuquerque Junior, Ricardo Luiz Cavalcanti deVerde, Isabel Bezerra LimaQuintans Júnior, Lucindo JoséBezerra, Daniel PereiraNogueira, Paulo Cesar de LimaAraujo, Adriano Antunes de Souza2017-08-17T14:10:19Z2017-08-17T14:10:19Z2016DORIA, G. A. A. et al. In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts. Phytomedicine, v. 23, p. 914–922, 2016.0944-7113https://www.arca.fiocruz.br/handle/icict/2065910.1016/j.phymed.2016.05.001engElsevierRemirea maritimaAntitumorSarcoma 180ApoptoseToxicidadeTunelRemirea maritimaAntitumorSarcoma 180ApoptosisToxicityTunelIn vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extractsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilTiradentes University. Institute of Technology and Research. Aracaju, SE, BrazilFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, BrazilFederal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Biology. São Cristóvão, SE, BrazilTiradentes University. Institute of Technology and Research. Aracaju, SE, BrazilTiradentes University. Institute of Technology and Research. Aracaju, SE, BrazilFederal University of Sergipe. Department of Physiology. São Cristóvão, SE, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Sergipe. Department of Chemistry. São Cristóvão, SE, BrazilFederal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, BrazilRemirea maritima has been widely used in the treatment of diarrhea, kidney disease, and high fever and for therapeutic purposes, such as an analgesic and anti-inflammatory. However, few scientific research studies on its medicinal properties have been reported. Purpose: The present study aimed to investigate the anticancer potential of aqueous extract (AE), 40% hydroalcoholic extracts (40HA) and 70% (70HA) from R. maritima in experimental models and to identify its phytochemical compounds. Methods: The chemical composition of AE, 40HA and 70HA was assessed by HPLC-DAD and ESI-IT-MS/MS . In vitro activity was determined on cultured tumor cell, NCI-H385N (Broncho-alveolar carcinoma), OVCAR- 8 (Ovarian carcinoma) and PC-3 M (prostate carcinoma) by the MTT assay, and the in vivo antitumor activity was assessed in Sarcoma 180-bearing mice. Toxicological parameters were also evaluated as well as the humoral immune response. Results: Among the aqueous and hydroalcoholic extracts of R. maritima , only 40HA showed in vitro bi- ological effect potential, presenting IC 50 values of 27.08, 46.62 and > 50 μg/ml for OVCAR-8, NCI-H385M and PC-3 M cells lines, respectively. Regarding chemical composition, a mixture of isovitexin-2 - O - β-D- glucopyranoside, vitexin-2 - O - β-D-glucopyranoside, luteolin-7- O -glucuronide and 1- O -(E)-caffeoyl- β-D- glucose were identified as the major phytochemical compounds of the extracts. In the in vivo study, the tumor inhibition rates were 57.16–62.57% at doses of 25 mg/kg and 50 mg/kg, respectively, and the tu- mor morphology presented increasing numbers of apoptotic cells. Additionally, 40HA also demonstrated significantly increased of OVA-specific total Ig. Conclusions: 40HA exhibited in vitro and in vivo anticancer properties without substantial toxicity that could be associated with its immunostimulating properties.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20659/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDória GA In vivo antitumor effect....pdfDória GA In vivo antitumor effect....pdfapplication/pdf2991613https://www.arca.fiocruz.br/bitstream/icict/20659/2/D%c3%b3ria%20GA%20In%20vivo%20antitumor%20effect....pdf72804791332cd39abe99ac99b2ff43bdMD52TEXTDória GA In vivo antitumor effect....pdf.txtDória GA In vivo antitumor effect....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
title In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
spellingShingle In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
Dória, Grace Anne Azevedo
Remirea maritima
Antitumor
Sarcoma 180
Apoptose
Toxicidade
Tunel
Remirea maritima
Antitumor
Sarcoma 180
Apoptosis
Toxicity
Tunel
title_short In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
title_full In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
title_fullStr In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
title_full_unstemmed In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
title_sort In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts
author Dória, Grace Anne Azevedo
author_facet Dória, Grace Anne Azevedo
Menezes, Paula dos Passos
Lima, Bruno dos Santos
Vasconcelos, Bruno S
Silva, Francilene Amaral da
Henriques, Raíssa Melo
Melo, Marcélia Garcez Dória de
Alves, Ângela Valéria Farias
Moraes, Manoel O
Pessoa, Cláudia do Ó
Carvalho, Adriana Andrade
Prata, Ana Paula do Nascimento
Albuquerque Junior, Ricardo Luiz Cavalcanti de
Verde, Isabel Bezerra Lima
Quintans Júnior, Lucindo José
Bezerra, Daniel Pereira
Nogueira, Paulo Cesar de Lima
Araujo, Adriano Antunes de Souza
author_role author
author2 Menezes, Paula dos Passos
Lima, Bruno dos Santos
Vasconcelos, Bruno S
Silva, Francilene Amaral da
Henriques, Raíssa Melo
Melo, Marcélia Garcez Dória de
Alves, Ângela Valéria Farias
Moraes, Manoel O
Pessoa, Cláudia do Ó
Carvalho, Adriana Andrade
Prata, Ana Paula do Nascimento
Albuquerque Junior, Ricardo Luiz Cavalcanti de
Verde, Isabel Bezerra Lima
Quintans Júnior, Lucindo José
Bezerra, Daniel Pereira
Nogueira, Paulo Cesar de Lima
Araujo, Adriano Antunes de Souza
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dória, Grace Anne Azevedo
Menezes, Paula dos Passos
Lima, Bruno dos Santos
Vasconcelos, Bruno S
Silva, Francilene Amaral da
Henriques, Raíssa Melo
Melo, Marcélia Garcez Dória de
Alves, Ângela Valéria Farias
Moraes, Manoel O
Pessoa, Cláudia do Ó
Carvalho, Adriana Andrade
Prata, Ana Paula do Nascimento
Albuquerque Junior, Ricardo Luiz Cavalcanti de
Verde, Isabel Bezerra Lima
Quintans Júnior, Lucindo José
Bezerra, Daniel Pereira
Nogueira, Paulo Cesar de Lima
Araujo, Adriano Antunes de Souza
dc.subject.other.pt_BR.fl_str_mv Remirea maritima
Antitumor
Sarcoma 180
Apoptose
Toxicidade
Tunel
topic Remirea maritima
Antitumor
Sarcoma 180
Apoptose
Toxicidade
Tunel
Remirea maritima
Antitumor
Sarcoma 180
Apoptosis
Toxicity
Tunel
dc.subject.en.pt_BR.fl_str_mv Remirea maritima
Antitumor
Sarcoma 180
Apoptosis
Toxicity
Tunel
description Federal University of Sergipe. Department of Pharmacy. São Cristóvão, SE, Brazil
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2017-08-17T14:10:19Z
dc.date.available.fl_str_mv 2017-08-17T14:10:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DORIA, G. A. A. et al. In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts. Phytomedicine, v. 23, p. 914–922, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20659
dc.identifier.issn.pt_BR.fl_str_mv 0944-7113
dc.identifier.doi.none.fl_str_mv 10.1016/j.phymed.2016.05.001
identifier_str_mv DORIA, G. A. A. et al. In vivo antitumor effect, induction of apoptosis and safety of Remirea maritima Aubl. (Cyperaceae) extracts. Phytomedicine, v. 23, p. 914–922, 2016.
0944-7113
10.1016/j.phymed.2016.05.001
url https://www.arca.fiocruz.br/handle/icict/20659
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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