No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/23838 |
Resumo: | Can archive publisher's version/PDF. Restrictions: 12 months embargo |
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Andrade, Simone LadeiaMelo, Gladson Naber P. deLima, Rita de Cássia de SouzaSalla, Laís C.Bastos, Melissa S.Rodrigues, Priscila T.Luz, Francisco das Chagas O.Ferreira, Marcelo U.2018-01-02T11:14:43Z2018-01-02T11:14:43Z2016ANDRADE, Simone Ladeia; et al. No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate–Mefloquine in Northwestern Brazil. Am. J. Trop. Med. Hyg., v.95, n.1, p.148–154, 2016.0002-9637https://www.arca.fiocruz.br/handle/icict/2383810.4269/ajtmh.16-0017Can archive publisher's version/PDF. Restrictions: 12 months embargoFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ. Brasil / Ministério da Saúde. Rede Amazônica de Vigilância da Resistência às Drogas Antimaláricas. Iniciativa Amazônica contra a Malária. Cruzeiro do Sul, AC, Brasil.Ministério da Saúde. Rede Amazônica de Vigilância da Resistência às Drogas Antimaláricas. Iniciativa Amazônica contra a Malária. Cruzeiro do Sul, AC, Brasil.Ministério da Saúde. Rede Amazônica de Vigilância da Resistência às Drogas Antimaláricas. Iniciativa Amazônica contra a Malária. Cruzeiro do Sul, AC, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de Brasília. Centro de Medicina Tropical. Brasília, DF, Brasil.Ministério da Saúde. Rede Amazônica de Vigilância da Resistência às Drogas Antimaláricas. Iniciativa Amazônica contra a Malária. Cruzeiro do Sul, AC, Brasil / Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.We evaluated the clinical efficacy of artesunate-mefloquine (ASMQ) fixed-dose combination to treat uncomplicated malaria in Juruá Valley, the main Plasmodium falciparum transmission hotspot in Brazil. Between November 2010 and February 2013, we enrolled 162 patients aged 4-73 years, with fever or a history of fever, and a single-species P. falciparum infection confirmed by microscopy and polymerase chain reaction (PCR). All 154 patients who completed the 42-day follow-up presented an adequate clinical and parasitologic response. ASMQ was well tolerated and no adverse event caused treatment interruption. Gametocytes were detected in 46.3% patients; 35.2% had gametocytes at enrollment, whereas others developed patent gametocytemia 1-14 days after starting ASMQ. By day 3 of treatment, all subjects had cleared asexual parasitemia, but parasite DNA remained PCR detectable in 37.6% of them. Day-3 PCR positivity was associated with prolonged gametocyte carriage. We found no molecular evidence of resistance to either MQ (pfmdr1 gene amplification) or AS (mutations in selected kelch13 gene domains known to be associated with AS resistance) in the local P. falciparum population. These results strongly support the use of ASMQ as a first-line regimen to treat uncomplicated P. falciparum malaria in northwestern Brazil, but underscore the need for gametocytocidal drugs to reduce the transmission potential of ASMQ-treated patients (ClinicalTrials.gov number NCT01144702).engThe American Society of Tropical Medicine and HygienePlasmodium falciparumMefloquinaTratamentoNoroeste do BrasilPlasmodium falciparumNorthwestern BrazilTreatmentmefloquineNo Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| title |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| spellingShingle |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil Andrade, Simone Ladeia Plasmodium falciparum Mefloquina Tratamento Noroeste do Brasil Plasmodium falciparum Northwestern Brazil Treatment mefloquine |
| title_short |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| title_full |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| title_fullStr |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| title_full_unstemmed |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| title_sort |
No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil |
| author |
Andrade, Simone Ladeia |
| author_facet |
Andrade, Simone Ladeia Melo, Gladson Naber P. de Lima, Rita de Cássia de Souza Salla, Laís C. Bastos, Melissa S. Rodrigues, Priscila T. Luz, Francisco das Chagas O. Ferreira, Marcelo U. |
| author_role |
author |
| author2 |
Melo, Gladson Naber P. de Lima, Rita de Cássia de Souza Salla, Laís C. Bastos, Melissa S. Rodrigues, Priscila T. Luz, Francisco das Chagas O. Ferreira, Marcelo U. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Andrade, Simone Ladeia Melo, Gladson Naber P. de Lima, Rita de Cássia de Souza Salla, Laís C. Bastos, Melissa S. Rodrigues, Priscila T. Luz, Francisco das Chagas O. Ferreira, Marcelo U. |
| dc.subject.other.pt_BR.fl_str_mv |
Plasmodium falciparum Mefloquina Tratamento Noroeste do Brasil |
| topic |
Plasmodium falciparum Mefloquina Tratamento Noroeste do Brasil Plasmodium falciparum Northwestern Brazil Treatment mefloquine |
| dc.subject.en.pt_BR.fl_str_mv |
Plasmodium falciparum Northwestern Brazil Treatment mefloquine |
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Can archive publisher's version/PDF. Restrictions: 12 months embargo |
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2016 |
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2016 |
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2018-01-02T11:14:43Z |
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2018-01-02T11:14:43Z |
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ANDRADE, Simone Ladeia; et al. No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate–Mefloquine in Northwestern Brazil. Am. J. Trop. Med. Hyg., v.95, n.1, p.148–154, 2016. |
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https://www.arca.fiocruz.br/handle/icict/23838 |
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0002-9637 |
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10.4269/ajtmh.16-0017 |
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ANDRADE, Simone Ladeia; et al. No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate–Mefloquine in Northwestern Brazil. Am. J. Trop. Med. Hyg., v.95, n.1, p.148–154, 2016. 0002-9637 10.4269/ajtmh.16-0017 |
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