Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57798 |
Resumo: | University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. |
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Cambou, Mary C.Liu, Christine M.Mok, ThaliaFajardo-Martinez, VivianaPaiola, Sophia G.Ibarrondo, Francisco J.Kerin, TaraFuller, TrevonTobin, Nicole H.Garcia, GustavoBhattacharya, DebikaAldrovandi, Grace M.Arumugaswami, VaithilingarajaSuan-Sin, FooJung, Jae U.Vasconcelos, ZiltonBrasil, PatriciaBrendolin, MichelleYang, OttoRao, RashmiNielsen-Saines, Karin2023-04-14T23:08:57Z2023-04-14T23:08:57Z2022CAMBOU, Mary C. et al. Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. The Journal of Infectious Diseases, v. 227, n. 2, p. 236-245, Jan 11, 2023.https://www.arca.fiocruz.br/handle/icict/57798engCOVID-19 na gravidezSARS-CoV-2 na gravidezTransferência transplacentáriaCOVID-19 in pregnancySARS-CoV-2 in pregnancyTransplacental transferLongitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA.University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA.University of California. Department of Molecular and Medical Pharmacology. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA.University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA.University of California. Department of Molecular and Medical Pharmacology. Los Angeles, California, USA.Department of Cancer Biology. Infection Biology Program and Global Center for Pathogen and Human Health Research Cleveland Clinic. Cleveland, Ohio, USA.Department of Cancer Biology. Infection Biology Program and Global Center for Pathogen and Human Health Research Cleveland Clinic. Cleveland, Ohio, USA.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Maternidade do Hospital Estadual Adão Pereira Nunes. Caxias, RJ, Brazil.University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA.University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA.University of California. Department of Obstetrics and Gynecology. David Geffen School of Medicine. Los Angeles, California, USA.University of California. David Geffen School of Medicine. Department of Pediatrics. Los Angeles, California, USA.Background: There are limited data on how coronavirus disease 2019 (COVID-19) severity, timing of infection, and subsequent vaccination impact transplacental transfer and persistence of maternal and infant antibodies. Methods: In a longitudinal cohort of pregnant women with polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, maternal/infant sera were collected at enrollment, delivery/birth, and 6 months. Anti-SARS-CoV-2 spike immunoglobulin (Ig)G, IgM, and IgA were measured by enzyme-linked immunosorbent assay. Results: Two-hundred fifty-six pregnant women and 135 infants were enrolled; 148 maternal and 122 neonatal specimens were collected at delivery/birth; 45 maternal and 48 infant specimens were collected at 6 months. Sixty-eight percent of women produced all anti-SARS-CoV-2 isotypes at delivery (IgG, IgM, IgA); 96% had at least 1 isotype. Symptomatic disease and vaccination before delivery were associated with higher maternal IgG at labor and delivery. Detectable IgG in infants dropped from 78% at birth to 52% at 6 months. In the multivariate analysis evaluating factors associated with detectable IgG in infants at delivery, significant predictors were 3rd trimester infection (odds ratio [OR] = 4.0), mild/moderate disease (OR = 4.8), severe/critical disease (OR = 6.3), and maternal vaccination before delivery (OR = 18.8). No factors were significant in the multivariate analysis at 6 months postpartum. Conclusions: Vaccination in pregnancy post-COVID-19 recovery is a strategy for boosting antibodies in mother-infant dyads.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57798/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Cambou_Mary_etal_INI_2023_PREPRINT.pdfve_Cambou_Mary_etal_INI_2023_PREPRINT.pdfapplication/pdf1069142https://www.arca.fiocruz.br/bitstream/icict/57798/2/ve_Cambou_Mary_etal_INI_2023_PREPRINT.pdf2f98284a539957977e7812b822a4f2ffMD52icict/577982023-04-14 20:08:58.834oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-04-14T23:08:58Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| title |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| spellingShingle |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy Cambou, Mary C. COVID-19 na gravidez SARS-CoV-2 na gravidez Transferência transplacentária COVID-19 in pregnancy SARS-CoV-2 in pregnancy Transplacental transfer |
| title_short |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| title_full |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| title_fullStr |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| title_full_unstemmed |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| title_sort |
Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads Following SARS-CoV-2 Infection in Pregnancy |
| author |
Cambou, Mary C. |
| author_facet |
Cambou, Mary C. Liu, Christine M. Mok, Thalia Fajardo-Martinez, Viviana Paiola, Sophia G. Ibarrondo, Francisco J. Kerin, Tara Fuller, Trevon Tobin, Nicole H. Garcia, Gustavo Bhattacharya, Debika Aldrovandi, Grace M. Arumugaswami, Vaithilingaraja Suan-Sin, Foo Jung, Jae U. Vasconcelos, Zilton Brasil, Patricia Brendolin, Michelle Yang, Otto Rao, Rashmi Nielsen-Saines, Karin |
| author_role |
author |
| author2 |
Liu, Christine M. Mok, Thalia Fajardo-Martinez, Viviana Paiola, Sophia G. Ibarrondo, Francisco J. Kerin, Tara Fuller, Trevon Tobin, Nicole H. Garcia, Gustavo Bhattacharya, Debika Aldrovandi, Grace M. Arumugaswami, Vaithilingaraja Suan-Sin, Foo Jung, Jae U. Vasconcelos, Zilton Brasil, Patricia Brendolin, Michelle Yang, Otto Rao, Rashmi Nielsen-Saines, Karin |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cambou, Mary C. Liu, Christine M. Mok, Thalia Fajardo-Martinez, Viviana Paiola, Sophia G. Ibarrondo, Francisco J. Kerin, Tara Fuller, Trevon Tobin, Nicole H. Garcia, Gustavo Bhattacharya, Debika Aldrovandi, Grace M. Arumugaswami, Vaithilingaraja Suan-Sin, Foo Jung, Jae U. Vasconcelos, Zilton Brasil, Patricia Brendolin, Michelle Yang, Otto Rao, Rashmi Nielsen-Saines, Karin |
| dc.subject.other.en_US.fl_str_mv |
COVID-19 na gravidez SARS-CoV-2 na gravidez Transferência transplacentária |
| topic |
COVID-19 na gravidez SARS-CoV-2 na gravidez Transferência transplacentária COVID-19 in pregnancy SARS-CoV-2 in pregnancy Transplacental transfer |
| dc.subject.en.en_US.fl_str_mv |
COVID-19 in pregnancy SARS-CoV-2 in pregnancy Transplacental transfer |
| description |
University of California. David Geffen School of Medicine. Department of Medicine. Los Angeles, California, USA. |
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2022 |
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2022 |
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2023-04-14T23:08:57Z |
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2023-04-14T23:08:57Z |
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CAMBOU, Mary C. et al. Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. The Journal of Infectious Diseases, v. 227, n. 2, p. 236-245, Jan 11, 2023. |
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https://www.arca.fiocruz.br/handle/icict/57798 |
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CAMBOU, Mary C. et al. Longitudinal Evaluation of Antibody Persistence in Mother-Infant Dyads After Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy. The Journal of Infectious Diseases, v. 227, n. 2, p. 236-245, Jan 11, 2023. |
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