Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Castro, Claudia G. S. Osorio de
Data de Publicação: 2015
Outros Autores: Suárez‑Mutis, Martha C., Miranda, Elaine S., Luz, Tatiana C. B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13199
Resumo: Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Núcleo de Assistência Farmacêutica. Rio de Janeiro, RJ, Brasil.
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spelling Castro, Claudia G. S. Osorio deSuárez‑Mutis, Martha C.Miranda, Elaine S.Luz, Tatiana C. B.2016-03-17T15:46:13Z2016-03-17T15:46:13Z2015CASTRO, Claudia G. S. et al. Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon. Malaria Journal, v.14:471, 7p, 2015.1475-2875https://www.arca.fiocruz.br/handle/icict/1319910.1186/s12936-015-0998-3engBioMed CentralDispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Núcleo de Assistência Farmacêutica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Farmácia. Departamento de Farmácia e Administração Farmacêutica. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Educação em Saúde e Ambiente. Belo Horizonte, MG, BrasilBackground: In Brazil, 99.7 % of malaria cases occur in the Amazon region. Although the number of cases is decreas‑ ing, the country accounted for almost 60 % of cases in the Americas Region, in 2013. Novel approaches for malaria treatment open the possibility of eliminating the disease, but suboptimal dispensing and lack of adherence influence treatment outcomes. The aim of this paper is to show the results on dispensing practices, non-adherence and deter‑ minants of non-adherence to treatment of non-complicated malaria. Methods: The study was conducted in six high-risk municipalities with Plasmodium vivax and Plasmodium falciparum transmission in the Brazilian Amazon and based on the theoretical framework of the Mafalda Project, which included investigation of dispensing and adherence. The World Health Organization Rapid Evaluation Method has been used to estimate sample size. Individuals over 15 years of age with malaria were approached at health facilities and invited to participate through informed consent. Data was collected in chart review forms focusing on diagnosis, Plasmodium type, prescribing, and dispensing (kind, quantity, labelling and procedures). Follow-up household interviews comple‑ mented data collection at health facility. Non-adherence was measured during the implementation phase, by selfreports and pill-counts. Analysis was descriptive and statistical tests were carried out. Determinants of non-adherence and quality of dispensing were assessed according to the literature. Results: The study involved 165 patients. Dispensing was done according to the national guidelines. Labelling was adequate for P. vivax but inadequate for P. falciparum medicines. Non-adherent patients were 12.1 % according to selfreports and 21.8 % according to pill-counts. Results point to greater non-adherence among all P. falciparum patients and among malaria non-naîve patients. More patients informed understanding adverse effects than ‘how to use’ anti-malarials. Conclusions: Non-adherent patients were mostly those with a P. falciparum diagnosis and those in their second or more malaria episode. New taxonomies and concepts on adherence stress the importance of focusing on the individual patient. Interventions targeted to and tailored for malaria patients must be addressed by health policy and implemented by managers and clinicians.MalariaBrazilDispensingAdherenceMedicinesMaláriaBrasilDispensador de MedicamentosAderênciaMedicamentosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13199/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALmarta_mutis_etal_ IOC_2015.pdfmarta_mutis_etal_ IOC_2015.pdfapplication/pdf977658https://www.arca.fiocruz.br/bitstream/icict/13199/2/marta_mutis_etal_%20IOC_2015.pdfc95e8c95f470666e41bf320ac07b5aa2MD52TEXTmarta_mutis_etal_ IOC_2015.pdf.txtmarta_mutis_etal_ IOC_2015.pdf.txtExtracted texttext/plain37260https://www.arca.fiocruz.br/bitstream/icict/13199/3/marta_mutis_etal_%20IOC_2015.pdf.txt95f5197bff54ccd184152b2ed82fae20MD53icict/131992023-09-05 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dc.title.pt_BR.fl_str_mv Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
title Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
spellingShingle Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
Castro, Claudia G. S. Osorio de
Malaria
Brazil
Dispensing
Adherence
Medicines
Malária
Brasil
Dispensador de Medicamentos
Aderência
Medicamentos
title_short Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
title_full Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
title_fullStr Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
title_full_unstemmed Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
title_sort Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon
author Castro, Claudia G. S. Osorio de
author_facet Castro, Claudia G. S. Osorio de
Suárez‑Mutis, Martha C.
Miranda, Elaine S.
Luz, Tatiana C. B.
author_role author
author2 Suárez‑Mutis, Martha C.
Miranda, Elaine S.
Luz, Tatiana C. B.
author2_role author
author
author
dc.contributor.author.fl_str_mv Castro, Claudia G. S. Osorio de
Suárez‑Mutis, Martha C.
Miranda, Elaine S.
Luz, Tatiana C. B.
dc.subject.en.pt_BR.fl_str_mv Malaria
Brazil
Dispensing
Adherence
Medicines
topic Malaria
Brazil
Dispensing
Adherence
Medicines
Malária
Brasil
Dispensador de Medicamentos
Aderência
Medicamentos
dc.subject.decs.pt_BR.fl_str_mv Malária
Brasil
Dispensador de Medicamentos
Aderência
Medicamentos
description Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Núcleo de Assistência Farmacêutica. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-03-17T15:46:13Z
dc.date.available.fl_str_mv 2016-03-17T15:46:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, Claudia G. S. et al. Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon. Malaria Journal, v.14:471, 7p, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13199
dc.identifier.issn.pt_BR.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-015-0998-3
identifier_str_mv CASTRO, Claudia G. S. et al. Dispensing and determinants of non‑adherence to treatment for non complicated malaria caused by Plasmodium vivax and Plasmodium falciparum in high‑risk municipalities in the Brazilian Amazon. Malaria Journal, v.14:471, 7p, 2015.
1475-2875
10.1186/s12936-015-0998-3
url https://www.arca.fiocruz.br/handle/icict/13199
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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