Derivation and validation of a novel severity scoring system for pneumonia at ICU admission
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41698 |
Resumo: | NIH (U01AI115940). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES. |
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Carmo, Thomas Azevedo doFerreira, Isabella Bonifácio BrigeMenezes, Rodrigo Carvalho deTelles, Gabriel PiñeiroOtero, Matheus LisboaArriaga Gutiérrez, María BelenFukutani, Kiyoshi FerreiraPamplona Neto, LicurgoAgareno, SydneyFilgueiras Filho, Nivaldo MenezesAndrade, Bruno de BezerrilAkrami, Kevan Michal2020-06-17T14:07:21Z2020-06-17T14:07:21Z2020CARMO, Thomas Azevedo do et al. Derivation and validation of a novel severity scoring system for pneumonia at ICU admission. Clinical Infectious Diseases, 2020.1058-4838https://www.arca.fiocruz.br/handle/icict/4169810.1093/cid/ciaa183NIH (U01AI115940). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES.Universidade Salvador. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil.Universidade do Estado da Bahia.Salvador, BA, Brasil.União Metropolitana para o Desenvolvimento da Educação e Cultura. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Salvador. Salvador, BA, Brasil.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil /Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Hospital de Cidade. Intensive Care Unit. Salvador, BA, Brazil.Hospital de Cidade. Intensive Care Unit. Salvador, BA, Brazil.Universidade Salvador. Salvador, BA, Brasil / Universidade do Estado da Bahia.Salvador, BA, Brasil / Hospital de Cidade. Salvador, BA, Brasil.Universidade Salvador. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / University of California. Department of Medicine. Division of Infectious Diseases and Pulmonary Critical Care and Sleep Medicine. San Diego, California.Severity stratification scores developed in Intensive Care Units (ICUs) are used in interventional studies to identify the most critically ill. Studies that evaluate accuracy of these scores in ICU patients admitted with pneumonia are lacking. This study aims to determine performance of severity scores as predictors of mortality in critically ill patients admitted with pneumonia. Methods: Prospective cohort study in a general ICU in Brazil. ICU severity scores (SAPS 3 and qSOFA), prognostic scores of pneumonia (CURB-65 and CRB-65), clinical and epidemiological variables in the first 6 hours of hospitalization were analyzed. Results: A total of 200 patients were included between August 2015 and July 2018 with a median age of 81 years (IQR 67-90) and female predominance (52%) primarily admitted from the emergency department (65%) with community acquired pneumonia (80.5%). Poor discriminative performance in predicting mortality was found with SAPS 3, CURB-65, CRB-65 and qSOFA. Multivariate regression identified variables independently associated with mortality that were used to develop a novel pneumonia specific ICU severity score (Pneumonia SHOCK score) that outperformed SAPS3, CURB-65 and CRB-65 (AUC 0.80 vs 0.74, 0.65 and 0.63, respectively). Discriminate function of the Pneumonia SHOCK score was validated in an external multi-center cohort of critically ill patients admitted with community acquired pneumonia (AUC 0.81).engOxford University PressPneumoniaUnidade de Tratamento IntensivoMortalidade.GravidadePneumoniaIntensive Care UnitMortalitySeverity ScoresDerivation and validation of a novel severity scoring system for pneumonia at ICU admissioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/41698/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarmo. T. A. Derivatiom....pdfCarmo. T. A. Derivatiom....pdfapplication/pdf1350086https://www.arca.fiocruz.br/bitstream/icict/41698/2/Carmo.%20T.%20A.%20Derivatiom....pdf2c078caf6f91e85899343a5d253ef452MD52TEXTCarmo. T. A. Derivatiom....pdf.txtCarmo. T. A. Derivatiom....pdf.txtExtracted texttext/plain37939https://www.arca.fiocruz.br/bitstream/icict/41698/3/Carmo.%20T.%20A.%20Derivatiom....pdf.txtf513db778fad0f1dfd985d084f01e44aMD53icict/416982023-03-15 14:34:26.257oai:www.arca.fiocruz.br:icict/41698Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| title |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| spellingShingle |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission Carmo, Thomas Azevedo do Pneumonia Unidade de Tratamento Intensivo Mortalidade. Gravidade Pneumonia Intensive Care Unit Mortality Severity Scores |
| title_short |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| title_full |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| title_fullStr |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| title_full_unstemmed |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| title_sort |
Derivation and validation of a novel severity scoring system for pneumonia at ICU admission |
| author |
Carmo, Thomas Azevedo do |
| author_facet |
Carmo, Thomas Azevedo do Ferreira, Isabella Bonifácio Brige Menezes, Rodrigo Carvalho de Telles, Gabriel Piñeiro Otero, Matheus Lisboa Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Pamplona Neto, Licurgo Agareno, Sydney Filgueiras Filho, Nivaldo Menezes Andrade, Bruno de Bezerril Akrami, Kevan Michal |
| author_role |
author |
| author2 |
Ferreira, Isabella Bonifácio Brige Menezes, Rodrigo Carvalho de Telles, Gabriel Piñeiro Otero, Matheus Lisboa Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Pamplona Neto, Licurgo Agareno, Sydney Filgueiras Filho, Nivaldo Menezes Andrade, Bruno de Bezerril Akrami, Kevan Michal |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carmo, Thomas Azevedo do Ferreira, Isabella Bonifácio Brige Menezes, Rodrigo Carvalho de Telles, Gabriel Piñeiro Otero, Matheus Lisboa Arriaga Gutiérrez, María Belen Fukutani, Kiyoshi Ferreira Pamplona Neto, Licurgo Agareno, Sydney Filgueiras Filho, Nivaldo Menezes Andrade, Bruno de Bezerril Akrami, Kevan Michal |
| dc.subject.other.pt_BR.fl_str_mv |
Pneumonia Unidade de Tratamento Intensivo Mortalidade. Gravidade |
| topic |
Pneumonia Unidade de Tratamento Intensivo Mortalidade. Gravidade Pneumonia Intensive Care Unit Mortality Severity Scores |
| dc.subject.en.pt_BR.fl_str_mv |
Pneumonia Intensive Care Unit Mortality Severity Scores |
| description |
NIH (U01AI115940). K.F.F. received a fellowship from the Programa Nacional de Pós-Doutorado, CAPES. |
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2020 |
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2020-06-17T14:07:21Z |
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2020-06-17T14:07:21Z |
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2020 |
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CARMO, Thomas Azevedo do et al. Derivation and validation of a novel severity scoring system for pneumonia at ICU admission. Clinical Infectious Diseases, 2020. |
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https://www.arca.fiocruz.br/handle/icict/41698 |
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1058-4838 |
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10.1093/cid/ciaa183 |
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CARMO, Thomas Azevedo do et al. Derivation and validation of a novel severity scoring system for pneumonia at ICU admission. Clinical Infectious Diseases, 2020. 1058-4838 10.1093/cid/ciaa183 |
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Oxford University Press |
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