Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression

Detalhes bibliográficos
Autor(a) principal: Cal, Tereza Cristina Minto Fontes
Data de Publicação: 2021
Outros Autores: Mattos, Rafael Teixeira, Medeiros, Nayara Ingrid, Pinto, Bruna Fernandes, Bezerra, Mayara Belchior, Souza, Bruna Roque, Dutra, Walderez Ornelas, Ferrari, Teresa Cristina de Abreu, Vidigal, Paula Vieira Teixeira, Faria, Luciana Costa, Couto, Cláudia Alves, Estanislau, Juliana de Assis Gomes Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51524
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.
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spelling Cal, Tereza Cristina Minto FontesMattos, Rafael TeixeiraMedeiros, Nayara IngridPinto, Bruna FernandesBezerra, Mayara BelchiorSouza, Bruna RoqueDutra, Walderez OrnelasFerrari, Teresa Cristina de AbreuVidigal, Paula Vieira TeixeiraFaria, Luciana CostaCouto, Cláudia AlvesEstanislau, Juliana de Assis Gomes Silva2022-03-03T17:50:32Z2022-03-03T17:50:32Z2021CAL, Tereza Cristina Minto Fontes et al. Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression. Front Immunol., v. 12, 708959, 2021. doi: 10.3389/fimmu.2021.7089591664-3224https://www.arca.fiocruz.br/handle/icict/5152410.3389/fimmu.2021.708959engFrontiers Research FoundationCrosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Imunologia Celular e Molecular. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Anatomia Patológica e Medicina Legal. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Hospital das Clínicas. Instituto Alfa de Gastroenterologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.Cytokines are involved in the immunopathogenesis of nonalcoholic fatty liver disease (NAFLD), but the relationship between them and clinical parameters of NAFLD progression is still unknown. Using flow cytometry, we evaluated the plasma levels of IL-1β, IL-6, IL-12, TNF and IL-10 and their association with clinical and biochemical parameters of liver function during simple steatosis (NAFL) and nonalcoholic steatohepatitis (NASH) in biopsy-proven patients. The NASH patients showed higher levels of IL-6 associated with a lower IL-10/IL-6 ratio. Besides heatmaps were similar in the NAFL and NASH groups, the same did not occur in signature curves, the NASH patients were high producers to IL-12 and IL-6 while the NAFL patients were not high producers of any cytokines evaluated. Integrative biomarker network analysis revealed that cytokines are differently correlated with clinical parameters, while IL-12, IL-10 presented moderate and negative correlations with glycemic and lipid profile in the NAFL group. The NASH group IL-12 and TNF revealed stronger and positive correlations with transient elastography parameters and NAFLD liver fibrosis score. These data suggest that IL-6 and IL-10 might act in chronic inflammation and insulin resistance whereas IL-12 and TNF may be involved in promoting liver damage and NAFLD progression. Plasma concentration analysis of these molecules and their association with clinical parameters can be used as new biomarkers to monitoring NAFLD progression and to reflect NASH development.biomarkerscytokinesimmune responseinflammationliver damagenonalcoholic fatty liver diseaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51524/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCrosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression - 5154.pdfCrosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression - 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dc.title.pt_BR.fl_str_mv Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
title Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
spellingShingle Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
Cal, Tereza Cristina Minto Fontes
biomarkers
cytokines
immune response
inflammation
liver damage
nonalcoholic fatty liver disease
title_short Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
title_full Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
title_fullStr Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
title_full_unstemmed Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
title_sort Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression
author Cal, Tereza Cristina Minto Fontes
author_facet Cal, Tereza Cristina Minto Fontes
Mattos, Rafael Teixeira
Medeiros, Nayara Ingrid
Pinto, Bruna Fernandes
Bezerra, Mayara Belchior
Souza, Bruna Roque
Dutra, Walderez Ornelas
Ferrari, Teresa Cristina de Abreu
Vidigal, Paula Vieira Teixeira
Faria, Luciana Costa
Couto, Cláudia Alves
Estanislau, Juliana de Assis Gomes Silva
author_role author
author2 Mattos, Rafael Teixeira
Medeiros, Nayara Ingrid
Pinto, Bruna Fernandes
Bezerra, Mayara Belchior
Souza, Bruna Roque
Dutra, Walderez Ornelas
Ferrari, Teresa Cristina de Abreu
Vidigal, Paula Vieira Teixeira
Faria, Luciana Costa
Couto, Cláudia Alves
Estanislau, Juliana de Assis Gomes Silva
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cal, Tereza Cristina Minto Fontes
Mattos, Rafael Teixeira
Medeiros, Nayara Ingrid
Pinto, Bruna Fernandes
Bezerra, Mayara Belchior
Souza, Bruna Roque
Dutra, Walderez Ornelas
Ferrari, Teresa Cristina de Abreu
Vidigal, Paula Vieira Teixeira
Faria, Luciana Costa
Couto, Cláudia Alves
Estanislau, Juliana de Assis Gomes Silva
dc.subject.en.pt_BR.fl_str_mv biomarkers
cytokines
immune response
inflammation
liver damage
nonalcoholic fatty liver disease
topic biomarkers
cytokines
immune response
inflammation
liver damage
nonalcoholic fatty liver disease
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-03T17:50:32Z
dc.date.available.fl_str_mv 2022-03-03T17:50:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAL, Tereza Cristina Minto Fontes et al. Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression. Front Immunol., v. 12, 708959, 2021. doi: 10.3389/fimmu.2021.708959
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51524
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2021.708959
identifier_str_mv CAL, Tereza Cristina Minto Fontes et al. Crosstalk Between Plasma Cytokines, Inflammation, and Liver Damage as a New Strategy to Monitoring NAFLD Progression. Front Immunol., v. 12, 708959, 2021. doi: 10.3389/fimmu.2021.708959
1664-3224
10.3389/fimmu.2021.708959
url https://www.arca.fiocruz.br/handle/icict/51524
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51524/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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