Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11472 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Delatorre, EdsonFernandez, José C. CoutoGuimarães, Monick LindenmeyerCardoso, Ludimila Paula VazAlcantara, Keila Correia deStefani, Mariane Martins de AraújoRomero, HectorFreire, Caio C. M.Iamarno, AtilaZanotto, Paolo M. de A.Morgado, Mariza G.Bello, Gonzalo2015-08-19T13:49:17Z2015-08-19T13:49:17Z2013DELATORRE, Edson; et al. Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil. Plos One, v.8, n.9, 13p, 2013.https://www.arca.fiocruz.br/handle/icict/1147210.1371/journal.pone.0074072engPlos OneTracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Universidad de la República. Facultad de Ciencias. Sección Biomatemáticas. Laboratorio de Organización y Evolución del Genoma. Montevideo, Uruguay.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. Laboratório de Evolução Molecular e Bioinformática. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia. Laboratório de Evolução Molecular e Bioinformática. São Paulo, SP, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Previous studies indicate that the HIV-1 subtype C epidemic in southern Brazil was initiated by the introduction of a single founder strain probably originating from east Africa. However, the exact country of origin of such a founder strain as well as the origin of the subtype C viruses detected outside the Brazilian southern region remains unknown. HIV-1 subtype C pol sequences isolated in the southern, southeastern and central-western Brazilian regions (n = 209) were compared with a large number (n ~ 2,000) of subtype C pol sequences of African origin. Maximumlikelihood analyses revealed that most HIV-1 subtype C Brazilian sequences branched in a single monophyletic clade (CBR-I), nested within a larger monophyletic lineage characteristic of east Africa. Bayesian analyses indicate that the CBR-I clade most probably originated in Burundi and was introduced into the Paraná state (southern region) around the middle 1970s, after which it rapidly disseminated to neighboring regions. The states of Paraná and Santa Catarina have been the most important hubs of subtype C dissemination, and routine travel and spatial accessibility seems to have been the major driving forces of this process. Five additional introductions of HIV-1 subtype C strains probably originated in eastern (n = 2), southern (n = 2) and central (n = 1) African countries were detected in the Rio de Janeiro state (southeastern region). These results indicate a continuous influx of HIV-1 subtype C strains of African origin into Brazil and also unveil the existence of unrecognized transmission networks linking this country to east Africa.HIV-1 subtype CBrazilOrigin and Northward DisseminationHIV-1Brasilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11472/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALedson_delatorre_etal_IOC_2013.pdfapplication/pdf4000582https://www.arca.fiocruz.br/bitstream/icict/11472/2/edson_delatorre_etal_IOC_2013.pdfd6f1e4de43cd25ba0c7c4bd8ea326cbaMD52TEXTedson_delatorre_etal_IOC_2013.pdf.txtedson_delatorre_etal_IOC_2013.pdf.txtExtracted texttext/plain51939https://www.arca.fiocruz.br/bitstream/icict/11472/3/edson_delatorre_etal_IOC_2013.pdf.txt11ce0e29ef35207f970a0f8ebc528240MD53icict/114722022-06-24 13:02:56.135oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:02:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| title |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| spellingShingle |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil Delatorre, Edson HIV-1 subtype C Brazil Origin and Northward Dissemination HIV-1 Brasil |
| title_short |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| title_full |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| title_fullStr |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| title_full_unstemmed |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| title_sort |
Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil |
| author |
Delatorre, Edson |
| author_facet |
Delatorre, Edson Fernandez, José C. Couto Guimarães, Monick Lindenmeyer Cardoso, Ludimila Paula Vaz Alcantara, Keila Correia de Stefani, Mariane Martins de Araújo Romero, Hector Freire, Caio C. M. Iamarno, Atila Zanotto, Paolo M. de A. Morgado, Mariza G. Bello, Gonzalo |
| author_role |
author |
| author2 |
Fernandez, José C. Couto Guimarães, Monick Lindenmeyer Cardoso, Ludimila Paula Vaz Alcantara, Keila Correia de Stefani, Mariane Martins de Araújo Romero, Hector Freire, Caio C. M. Iamarno, Atila Zanotto, Paolo M. de A. Morgado, Mariza G. Bello, Gonzalo |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Delatorre, Edson Fernandez, José C. Couto Guimarães, Monick Lindenmeyer Cardoso, Ludimila Paula Vaz Alcantara, Keila Correia de Stefani, Mariane Martins de Araújo Romero, Hector Freire, Caio C. M. Iamarno, Atila Zanotto, Paolo M. de A. Morgado, Mariza G. Bello, Gonzalo |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 subtype C Brazil Origin and Northward Dissemination |
| topic |
HIV-1 subtype C Brazil Origin and Northward Dissemination HIV-1 Brasil |
| dc.subject.decs.pt_BR.fl_str_mv |
HIV-1 Brasil |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2013 |
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2013 |
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2015-08-19T13:49:17Z |
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2015-08-19T13:49:17Z |
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DELATORRE, Edson; et al. Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil. Plos One, v.8, n.9, 13p, 2013. |
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https://www.arca.fiocruz.br/handle/icict/11472 |
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10.1371/journal.pone.0074072 |
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DELATORRE, Edson; et al. Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil. Plos One, v.8, n.9, 13p, 2013. 10.1371/journal.pone.0074072 |
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