Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59349 |
Resumo: | This research received funding from the São Paulo Research Foundation (FAPESP), grant no. 2018/16893-8. |
| id |
CRUZ_cfa06ce9ece39d879c288a5210713e87 |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/59349 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Oliveira, Jardel Corrêa deAlves, Maíra RamosLopes, Luis Phillipe NagemIwami, Rodrigo SuguimotoMotter, Fabiane RaquelBergamaschi, Cristiane de CássiaSilva, Marcus TolentinoScalco, Diogo LuisLucio, Donavan de SouzaMazzei, Lauren GiusttiDerech, Rodrigo D’AgostiniPereira, Tiago VeigaBarreto, Jorge Otávio MaiaLopes, Luciane Cruz2023-07-02T22:39:05Z2023-07-02T22:39:05Z2022OLIVEIRA, Jardel Corrêa de et al. Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol. BMJ Open, [s.l.], v. 12, n. 2, e. 057094, 2022.CRD420212510512044-605535210346PMC8883265https://www.arca.fiocruz.br/handle/icict/5934910.1136/bmjopen-2021-0570942044-6055This research received funding from the São Paulo Research Foundation (FAPESP), grant no. 2018/16893-8.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brasil / Florianópolis Family Medicine Residency Program. Family Physician. Florianópolis, SC, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brasil.Federal University of Rio de Janeiro. Pharmacy Undergraduate Course. Rio de Janeiro, RJ, Brazil.University of Sorocaba. Nursing Undergraduate Course. Sorocaba, SP, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.Federal University of São Carlos. Department of Economics. Sorocaba, SP, Brazil.Florianópolis Family Medicine Residency Program. Family Physician. Florianópolis, SC, Brazil.Florianópolis Family Medicine Residency Program. Family Physician. Florianópolis, SC, Brazil.University of Sorocaba. Department of Physiotherapy. Sorocaba, SP, Brazil.Municipal Health Department of the Florianópolis City Hall. Florianópolis, SC, Brazil.University of Leicester. Department of Health Sciences. Leicester, United Kingdom / University of Toronto. St. Michael’s Hospital. Applied Health Research Centre. Toronto, ON, Canada.Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.Introduction: Antiretroviral therapy (ART) for HIV/AIDS is associated with adverse events (AEs). However, little is known about the differences in the risk of AEs between women and men living with HIV/AIDS. This study aims to determine (1) whether there are sex differences in the risk of AEs in people with HIV/AIDS treated with ART and (2) the prevalence of AEs to the reproductive system and bone mineral density in women. Methods and analysis: This systematic review (SR) will include randomised trials evaluating ART in people living with HIV/AIDS with at least 12 weeks of duration follow-up. Searches will be conducted in Medline, Embase, Cochrane Library, Epistemonikos, Lilacs, trial registries and grey literature databases, without restriction on publication status, year of publication and language. The primary outcome will be the risk of ART discontinuation or drop-outs/withdrawals of ART due to AEs and the number of any treatment-emergent AE. The secondary outcomes are the incidence of serious clinic or laboratory (grade 3 and/or 4) treatment-emergent AEs, hospitalisation, death and AEs specific to the reproductive system and bone mineral density (osteoporosis, osteopenia and fractures) of women. Selection, data extraction and quality assessment will be performed by pairs of reviewers. Cochrane collaboration tools will be used to assess the risk of bias. If appropriate, a meta-analysis will be conducted to synthesise results. The overall quality of the evidence for each outcome will be determined by the Grades of Recommendation, Assessment, Development and Evaluation. Ethics and dissemination: The results of this SR will assist the formulation of public policies aimed at the management and monitoring of AEs of ART in people living with HIV/AIDS. A deliberative dialogue will be scheduled with the Department of Chronic Conditions and Sexually Transmitted Infections of Brazil’s Ministry of Health to align the project with policymakers’ interests.engBMJ Publishing Group Ltd.Acquired Immunodeficiency SyndromeAnti-Retroviral Agents / adverse effectsBiasFemaleHIV Infections / drug therapyHumansMaleMeta-Analysis as TopicSex CharacteristicsSystematic Reviews as TopicAcquired Immunodeficiency SyndromeHIV infectionsAdverse eventsClinical pharmacologyHealth policySíndrome de Imunodeficiência AdquiridaAntirretrovirais / efeitos adversosViésInfecções por HIV / tratamento farmacológicoMetanálise como AssuntoCaracteres SexuaisRevisões Sistemáticas como AssuntoSex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59349/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJorge_Barreto_etal_FiocruzBSB_2022.pdfJorge_Barreto_etal_FiocruzBSB_2022.pdfARTIGO + MATERIAL SUPLEMENTARapplication/pdf563324https://www.arca.fiocruz.br/bitstream/icict/59349/2/Jorge_Barreto_etal_FiocruzBSB_2022.pdfcfe8d142ae929058da3363a2046f80bdMD52icict/593492023-07-02 19:39:06.66oai:www.arca.fiocruz.br:icict/59349Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-02T22:39:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| title |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| spellingShingle |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol Oliveira, Jardel Corrêa de Acquired Immunodeficiency Syndrome Anti-Retroviral Agents / adverse effects Bias Female HIV Infections / drug therapy Humans Male Meta-Analysis as Topic Sex Characteristics Systematic Reviews as Topic Acquired Immunodeficiency Syndrome HIV infections Adverse events Clinical pharmacology Health policy Síndrome de Imunodeficiência Adquirida Antirretrovirais / efeitos adversos Viés Infecções por HIV / tratamento farmacológico Metanálise como Assunto Caracteres Sexuais Revisões Sistemáticas como Assunto |
| title_short |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| title_full |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| title_fullStr |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| title_full_unstemmed |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| title_sort |
Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol |
| author |
Oliveira, Jardel Corrêa de |
| author_facet |
Oliveira, Jardel Corrêa de Alves, Maíra Ramos Lopes, Luis Phillipe Nagem Iwami, Rodrigo Suguimoto Motter, Fabiane Raquel Bergamaschi, Cristiane de Cássia Silva, Marcus Tolentino Scalco, Diogo Luis Lucio, Donavan de Souza Mazzei, Lauren Giustti Derech, Rodrigo D’Agostini Pereira, Tiago Veiga Barreto, Jorge Otávio Maia Lopes, Luciane Cruz |
| author_role |
author |
| author2 |
Alves, Maíra Ramos Lopes, Luis Phillipe Nagem Iwami, Rodrigo Suguimoto Motter, Fabiane Raquel Bergamaschi, Cristiane de Cássia Silva, Marcus Tolentino Scalco, Diogo Luis Lucio, Donavan de Souza Mazzei, Lauren Giustti Derech, Rodrigo D’Agostini Pereira, Tiago Veiga Barreto, Jorge Otávio Maia Lopes, Luciane Cruz |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Jardel Corrêa de Alves, Maíra Ramos Lopes, Luis Phillipe Nagem Iwami, Rodrigo Suguimoto Motter, Fabiane Raquel Bergamaschi, Cristiane de Cássia Silva, Marcus Tolentino Scalco, Diogo Luis Lucio, Donavan de Souza Mazzei, Lauren Giustti Derech, Rodrigo D’Agostini Pereira, Tiago Veiga Barreto, Jorge Otávio Maia Lopes, Luciane Cruz |
| dc.subject.mesh.en_US.fl_str_mv |
Acquired Immunodeficiency Syndrome Anti-Retroviral Agents / adverse effects Bias Female HIV Infections / drug therapy Humans Male Meta-Analysis as Topic Sex Characteristics Systematic Reviews as Topic |
| topic |
Acquired Immunodeficiency Syndrome Anti-Retroviral Agents / adverse effects Bias Female HIV Infections / drug therapy Humans Male Meta-Analysis as Topic Sex Characteristics Systematic Reviews as Topic Acquired Immunodeficiency Syndrome HIV infections Adverse events Clinical pharmacology Health policy Síndrome de Imunodeficiência Adquirida Antirretrovirais / efeitos adversos Viés Infecções por HIV / tratamento farmacológico Metanálise como Assunto Caracteres Sexuais Revisões Sistemáticas como Assunto |
| dc.subject.en.en_US.fl_str_mv |
Acquired Immunodeficiency Syndrome HIV infections Adverse events Clinical pharmacology Health policy |
| dc.subject.decs.en_US.fl_str_mv |
Síndrome de Imunodeficiência Adquirida Antirretrovirais / efeitos adversos Viés Infecções por HIV / tratamento farmacológico Metanálise como Assunto Caracteres Sexuais Revisões Sistemáticas como Assunto |
| description |
This research received funding from the São Paulo Research Foundation (FAPESP), grant no. 2018/16893-8. |
| publishDate |
2022 |
| dc.date.issued.fl_str_mv |
2022 |
| dc.date.accessioned.fl_str_mv |
2023-07-02T22:39:05Z |
| dc.date.available.fl_str_mv |
2023-07-02T22:39:05Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
OLIVEIRA, Jardel Corrêa de et al. Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol. BMJ Open, [s.l.], v. 12, n. 2, e. 057094, 2022. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/59349 |
| dc.identifier.govdoc.none.fl_str_mv |
CRD42021251051 |
| dc.identifier.issn.en_US.fl_str_mv |
2044-6055 |
| dc.identifier.other.none.fl_str_mv |
35210346 PMC8883265 |
| dc.identifier.doi.none.fl_str_mv |
10.1136/bmjopen-2021-057094 |
| dc.identifier.eissn.none.fl_str_mv |
2044-6055 |
| identifier_str_mv |
OLIVEIRA, Jardel Corrêa de et al. Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol. BMJ Open, [s.l.], v. 12, n. 2, e. 057094, 2022. CRD42021251051 2044-6055 35210346 PMC8883265 10.1136/bmjopen-2021-057094 |
| url |
https://www.arca.fiocruz.br/handle/icict/59349 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
BMJ Publishing Group Ltd. |
| publisher.none.fl_str_mv |
BMJ Publishing Group Ltd. |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/59349/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/59349/2/Jorge_Barreto_etal_FiocruzBSB_2022.pdf |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 cfe8d142ae929058da3363a2046f80bd |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813008894733058048 |