Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol

Detalhes bibliográficos
Autor(a) principal: Oliveira, Jardel Corrêa de
Data de Publicação: 2022
Outros Autores: Alves, Maíra Ramos, Lopes, Luis Phillipe Nagem, Iwami, Rodrigo Suguimoto, Motter, Fabiane Raquel, Bergamaschi, Cristiane de Cássia, Silva, Marcus Tolentino, Scalco, Diogo Luis, Lucio, Donavan de Souza, Mazzei, Lauren Giustti, Derech, Rodrigo D’Agostini, Pereira, Tiago Veiga, Barreto, Jorge Otávio Maia, Lopes, Luciane Cruz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59349
Resumo: This research received funding from the São Paulo Research Foundation (FAPESP), grant no. 2018/16893-8.
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spelling Oliveira, Jardel Corrêa deAlves, Maíra RamosLopes, Luis Phillipe NagemIwami, Rodrigo SuguimotoMotter, Fabiane RaquelBergamaschi, Cristiane de CássiaSilva, Marcus TolentinoScalco, Diogo LuisLucio, Donavan de SouzaMazzei, Lauren GiusttiDerech, Rodrigo D’AgostiniPereira, Tiago VeigaBarreto, Jorge Otávio MaiaLopes, Luciane Cruz2023-07-02T22:39:05Z2023-07-02T22:39:05Z2022OLIVEIRA, Jardel Corrêa de et al. Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol. BMJ Open, [s.l.], v. 12, n. 2, e. 057094, 2022.CRD420212510512044-605535210346PMC8883265https://www.arca.fiocruz.br/handle/icict/5934910.1136/bmjopen-2021-0570942044-6055This research received funding from the São Paulo Research Foundation (FAPESP), grant no. 2018/16893-8.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brasil / Florianópolis Family Medicine Residency Program. Family Physician. Florianópolis, SC, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brasil.Federal University of Rio de Janeiro. Pharmacy Undergraduate Course. Rio de Janeiro, RJ, Brazil.University of Sorocaba. Nursing Undergraduate Course. Sorocaba, SP, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.Federal University of São Carlos. Department of Economics. Sorocaba, SP, Brazil.Florianópolis Family Medicine Residency Program. Family Physician. Florianópolis, SC, Brazil.Florianópolis Family Medicine Residency Program. Family Physician. Florianópolis, SC, Brazil.University of Sorocaba. Department of Physiotherapy. Sorocaba, SP, Brazil.Municipal Health Department of the Florianópolis City Hall. Florianópolis, SC, Brazil.University of Leicester. Department of Health Sciences. Leicester, United Kingdom / University of Toronto. St. Michael’s Hospital. Applied Health Research Centre. Toronto, ON, Canada.Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.University of Sorocaba. Graduate Course in Pharmaceutical Sciences. Sorocaba, SP, Brazil.Introduction: Antiretroviral therapy (ART) for HIV/AIDS is associated with adverse events (AEs). However, little is known about the differences in the risk of AEs between women and men living with HIV/AIDS. This study aims to determine (1) whether there are sex differences in the risk of AEs in people with HIV/AIDS treated with ART and (2) the prevalence of AEs to the reproductive system and bone mineral density in women. Methods and analysis: This systematic review (SR) will include randomised trials evaluating ART in people living with HIV/AIDS with at least 12 weeks of duration follow-up. Searches will be conducted in Medline, Embase, Cochrane Library, Epistemonikos, Lilacs, trial registries and grey literature databases, without restriction on publication status, year of publication and language. The primary outcome will be the risk of ART discontinuation or drop-outs/withdrawals of ART due to AEs and the number of any treatment-emergent AE. The secondary outcomes are the incidence of serious clinic or laboratory (grade 3 and/or 4) treatment-emergent AEs, hospitalisation, death and AEs specific to the reproductive system and bone mineral density (osteoporosis, osteopenia and fractures) of women. Selection, data extraction and quality assessment will be performed by pairs of reviewers. Cochrane collaboration tools will be used to assess the risk of bias. If appropriate, a meta-analysis will be conducted to synthesise results. The overall quality of the evidence for each outcome will be determined by the Grades of Recommendation, Assessment, Development and Evaluation. Ethics and dissemination: The results of this SR will assist the formulation of public policies aimed at the management and monitoring of AEs of ART in people living with HIV/AIDS. A deliberative dialogue will be scheduled with the Department of Chronic Conditions and Sexually Transmitted Infections of Brazil’s Ministry of Health to align the project with policymakers’ interests.engBMJ Publishing Group Ltd.Acquired Immunodeficiency SyndromeAnti-Retroviral Agents / adverse effectsBiasFemaleHIV Infections / drug therapyHumansMaleMeta-Analysis as TopicSex CharacteristicsSystematic Reviews as TopicAcquired Immunodeficiency SyndromeHIV infectionsAdverse eventsClinical pharmacologyHealth policySíndrome de Imunodeficiência AdquiridaAntirretrovirais / efeitos adversosViésInfecções por HIV / tratamento farmacológicoMetanálise como AssuntoCaracteres SexuaisRevisões Sistemáticas como AssuntoSex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
title Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
spellingShingle Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
Oliveira, Jardel Corrêa de
Acquired Immunodeficiency Syndrome
Anti-Retroviral Agents / adverse effects
Bias
Female
HIV Infections / drug therapy
Humans
Male
Meta-Analysis as Topic
Sex Characteristics
Systematic Reviews as Topic
Acquired Immunodeficiency Syndrome
HIV infections
Adverse events
Clinical pharmacology
Health policy
Síndrome de Imunodeficiência Adquirida
Antirretrovirais / efeitos adversos
Viés
Infecções por HIV / tratamento farmacológico
Metanálise como Assunto
Caracteres Sexuais
Revisões Sistemáticas como Assunto
title_short Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
title_full Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
title_fullStr Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
title_full_unstemmed Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
title_sort Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol
author Oliveira, Jardel Corrêa de
author_facet Oliveira, Jardel Corrêa de
Alves, Maíra Ramos
Lopes, Luis Phillipe Nagem
Iwami, Rodrigo Suguimoto
Motter, Fabiane Raquel
Bergamaschi, Cristiane de Cássia
Silva, Marcus Tolentino
Scalco, Diogo Luis
Lucio, Donavan de Souza
Mazzei, Lauren Giustti
Derech, Rodrigo D’Agostini
Pereira, Tiago Veiga
Barreto, Jorge Otávio Maia
Lopes, Luciane Cruz
author_role author
author2 Alves, Maíra Ramos
Lopes, Luis Phillipe Nagem
Iwami, Rodrigo Suguimoto
Motter, Fabiane Raquel
Bergamaschi, Cristiane de Cássia
Silva, Marcus Tolentino
Scalco, Diogo Luis
Lucio, Donavan de Souza
Mazzei, Lauren Giustti
Derech, Rodrigo D’Agostini
Pereira, Tiago Veiga
Barreto, Jorge Otávio Maia
Lopes, Luciane Cruz
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Jardel Corrêa de
Alves, Maíra Ramos
Lopes, Luis Phillipe Nagem
Iwami, Rodrigo Suguimoto
Motter, Fabiane Raquel
Bergamaschi, Cristiane de Cássia
Silva, Marcus Tolentino
Scalco, Diogo Luis
Lucio, Donavan de Souza
Mazzei, Lauren Giustti
Derech, Rodrigo D’Agostini
Pereira, Tiago Veiga
Barreto, Jorge Otávio Maia
Lopes, Luciane Cruz
dc.subject.mesh.en_US.fl_str_mv Acquired Immunodeficiency Syndrome
Anti-Retroviral Agents / adverse effects
Bias
Female
HIV Infections / drug therapy
Humans
Male
Meta-Analysis as Topic
Sex Characteristics
Systematic Reviews as Topic
topic Acquired Immunodeficiency Syndrome
Anti-Retroviral Agents / adverse effects
Bias
Female
HIV Infections / drug therapy
Humans
Male
Meta-Analysis as Topic
Sex Characteristics
Systematic Reviews as Topic
Acquired Immunodeficiency Syndrome
HIV infections
Adverse events
Clinical pharmacology
Health policy
Síndrome de Imunodeficiência Adquirida
Antirretrovirais / efeitos adversos
Viés
Infecções por HIV / tratamento farmacológico
Metanálise como Assunto
Caracteres Sexuais
Revisões Sistemáticas como Assunto
dc.subject.en.en_US.fl_str_mv Acquired Immunodeficiency Syndrome
HIV infections
Adverse events
Clinical pharmacology
Health policy
dc.subject.decs.en_US.fl_str_mv Síndrome de Imunodeficiência Adquirida
Antirretrovirais / efeitos adversos
Viés
Infecções por HIV / tratamento farmacológico
Metanálise como Assunto
Caracteres Sexuais
Revisões Sistemáticas como Assunto
description This research received funding from the São Paulo Research Foundation (FAPESP), grant no. 2018/16893-8.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-07-02T22:39:05Z
dc.date.available.fl_str_mv 2023-07-02T22:39:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Jardel Corrêa de et al. Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol. BMJ Open, [s.l.], v. 12, n. 2, e. 057094, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59349
dc.identifier.govdoc.none.fl_str_mv CRD42021251051
dc.identifier.issn.en_US.fl_str_mv 2044-6055
dc.identifier.other.none.fl_str_mv 35210346
PMC8883265
dc.identifier.doi.none.fl_str_mv 10.1136/bmjopen-2021-057094
dc.identifier.eissn.none.fl_str_mv 2044-6055
identifier_str_mv OLIVEIRA, Jardel Corrêa de et al. Sex differences and adverse events of antiretrovirals in people living with HIV/AIDS: a systematic review and meta-analysis protocol. BMJ Open, [s.l.], v. 12, n. 2, e. 057094, 2022.
CRD42021251051
2044-6055
35210346
PMC8883265
10.1136/bmjopen-2021-057094
url https://www.arca.fiocruz.br/handle/icict/59349
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ Publishing Group Ltd.
publisher.none.fl_str_mv BMJ Publishing Group Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/59349/2/Jorge_Barreto_etal_FiocruzBSB_2022.pdf
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