Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Júlia H.V.
Data de Publicação: 2023
Outros Autores: Carvalho, Alexandre B. de, Silva, Valdenizia R., Santos, Luciano de S., Soares, Milena B. P., Bezerra, Daniel P., Oliveira, Katia M., Corrêa, Rodrigo S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59039
Resumo: Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Universidade Federal de Ouro Preto (UFOP).
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spelling Rodrigues, Júlia H.V.Carvalho, Alexandre B. deSilva, Valdenizia R.Santos, Luciano de S.Soares, Milena B. P.Bezerra, Daniel P.Oliveira, Katia M.Corrêa, Rodrigo S.2023-06-15T13:21:46Z2023-06-15T13:21:46Z2023RODRIGUES, Júlia H. V. et al. Copper (II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells. Polyhedron, v. 239, p. 1-8, 2023.1873-3719https://www.arca.fiocruz.br/handle/icict/5903910.1016/j.poly.2023.116431Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Universidade Federal de Ouro Preto (UFOP).Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil / SENAI CIMATEC. Instituto SENAI de Inovação em Sistemas Avançados de Saúde. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade de Brasília. Instituto de Química. Campus Darcy Ribeiro. Brasília, DF, Brasil.Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Departamento de Química. Campus Morro do Cruzeiro. Preto, MG, Brasil.Here, we report four new heteroleptic Cu(II) complexes with the formula [Cu(bipy)(2H4MeBz)]NO3 (1), [Cu(phen)(2H4MeBz)]NO3 (2), [Cu(bipy)(2H4OcBz)]NO3 (3) and [Cu(phen)(2H4OcBz)]NO3 (4), where the ligands are 2-hydroxy-4-methoxybenzophenone (2H4MeBz), 2-hydroxy-4-(octyloxy)benzophenone (2H4OcBz), 2,2′-bipiridine (bipy) and 1,10-phenantroline (phen). All compounds present two bidentate ligands, a monoanionic 2-hydroxybenzophenone, forming a six-membered chelate ring and the diiminic ring forming a five-membered chelate ring, as well as one nitrate as counterion located at the axial position, as suggested by the crystal structure of complex 2. Complex/DNA interaction studies were also performed using spectroscopic titration (Kb close to 104 M−1), viscosity, Hoechst 33258 competition, and circular dichroism, revealing a moderate interaction between them. Additionally, complexes 1–4 moderately interact with BSA (Bovine Serum Albumin). The compounds were evaluated against HCT116 (human colon carcinoma) and HepG2 (human hepatocellular carcinoma) cancer cells and against MRC-5 (human lung fibroblast), a noncancer cells. The cytotoxic results suggest that complexes 2 and 4 are more cytotoxic than 1 and 3, showing that the presence of phen ligand may play an important role in increasing the biological effect of the compounds.engElsevierCobre(II)Diimines2-hidroxibenzofenonasheterolépticoDNABSACopper(II)Diimines2-HydroxybenzophenonesHeterolepticDNABSACobreDNACopper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59039/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALRodrigues, J. H. Copper(II) diiminic....pdfRodrigues, J. H. Copper(II) diiminic....pdfapplication/pdf2382251https://www.arca.fiocruz.br/bitstream/icict/59039/2/Rodrigues%2c%20J.%20H.%20%20Copper%28II%29%20diiminic....pdf301d474d3a59fe78948c4e5916321f65MD52icict/590392023-06-15 10:21:47.355oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-15T13:21:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
title Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
spellingShingle Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
Rodrigues, Júlia H.V.
Cobre(II)
Diimines
2-hidroxibenzofenonas
heteroléptico
DNA
BSA
Copper(II)
Diimines
2-Hydroxybenzophenones
Heteroleptic
DNA
BSA
Cobre
DNA
title_short Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
title_full Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
title_fullStr Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
title_full_unstemmed Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
title_sort Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells
author Rodrigues, Júlia H.V.
author_facet Rodrigues, Júlia H.V.
Carvalho, Alexandre B. de
Silva, Valdenizia R.
Santos, Luciano de S.
Soares, Milena B. P.
Bezerra, Daniel P.
Oliveira, Katia M.
Corrêa, Rodrigo S.
author_role author
author2 Carvalho, Alexandre B. de
Silva, Valdenizia R.
Santos, Luciano de S.
Soares, Milena B. P.
Bezerra, Daniel P.
Oliveira, Katia M.
Corrêa, Rodrigo S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Júlia H.V.
Carvalho, Alexandre B. de
Silva, Valdenizia R.
Santos, Luciano de S.
Soares, Milena B. P.
Bezerra, Daniel P.
Oliveira, Katia M.
Corrêa, Rodrigo S.
dc.subject.other.en_US.fl_str_mv Cobre(II)
Diimines
2-hidroxibenzofenonas
heteroléptico
DNA
BSA
topic Cobre(II)
Diimines
2-hidroxibenzofenonas
heteroléptico
DNA
BSA
Copper(II)
Diimines
2-Hydroxybenzophenones
Heteroleptic
DNA
BSA
Cobre
DNA
dc.subject.en.en_US.fl_str_mv Copper(II)
Diimines
2-Hydroxybenzophenones
Heteroleptic
DNA
BSA
dc.subject.decs.en_US.fl_str_mv Cobre
DNA
description Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Universidade Federal de Ouro Preto (UFOP).
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-15T13:21:46Z
dc.date.available.fl_str_mv 2023-06-15T13:21:46Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RODRIGUES, Júlia H. V. et al. Copper (II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells. Polyhedron, v. 239, p. 1-8, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59039
dc.identifier.issn.en_US.fl_str_mv 1873-3719
dc.identifier.doi.none.fl_str_mv 10.1016/j.poly.2023.116431
identifier_str_mv RODRIGUES, Júlia H. V. et al. Copper (II)/diiminic complexes based on 2-hydroxybenzophenones: DNA and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells. Polyhedron, v. 239, p. 1-8, 2023.
1873-3719
10.1016/j.poly.2023.116431
url https://www.arca.fiocruz.br/handle/icict/59039
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59039/1/license.txt
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