Influence of endogamy and mitochondrial DNA on immunological parameters in cattle

Detalhes bibliográficos
Autor(a) principal: Macedo, Auricélio Alves de
Data de Publicação: 2014
Outros Autores: Bittar, Joely Ferreira Figueiredo, Bassi, Paula Boeira, Ronda, Juliano Bergamo, Bittar, Eustáquio Rezende, Paneto, João Cláudio do Carmo, Araújo, Márcio Sobreira Silva, Santos, Renato de Lima, Martins Filho, Olindo Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9533
Resumo: Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil.
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spelling Macedo, Auricélio Alves deBittar, Joely Ferreira FigueiredoBassi, Paula BoeiraRonda, Juliano BergamoBittar, Eustáquio RezendePaneto, João Cláudio do CarmoAraújo, Márcio Sobreira SilvaSantos, Renato de LimaMartins Filho, Olindo Assis2015-02-23T15:40:24Z2015-02-23T15:40:24Z2014MACEDO, Auricélio Alves de et al. Influence of endogamy and mitochondrial DNA on immunological parameters in cattle. BMC Veterinary Research, v. 10, p. 79, 20141746-6148https://www.arca.fiocruz.br/handle/icict/953310.1186/1746-6148-10-79engBioMed Central Ltd.Influence of endogamy and mitochondrial DNA on immunological parameters in cattleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil.Universidade de Uberaba. Uberaba, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade de Uberaba. Uberaba, MG, Brazil.Universidade de Uberaba. Uberaba, MG, Brazil.Universidade de Uberaba. Uberaba, MG, Brazil.Universidade de Uberaba. Uberaba, MG, Brazil.Universidade de Uberaba. Uberaba, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilBackground: Endogamy increases the risk of manifestation of deleterious recessive genes. Mitochondrial DNA allows the separation of American Zebu (Bos indicus and Bos taurus) and evaluate the effect of mitochondrial DNA on productive traits of cattle. However, the effect of endogamy and mitochondrial DNA (mtDNA) on the immune system remains unclear. The aim of this study was to evaluate the association between endogamy, mtDNA and immune parameters. Results: A total of 86 cattle (43 cows and 43 calves) were used in this study. Age, endogamy, milk yield, and origin of mtDNA were measured and their influence on immunological parameters was evaluated. Older cows had increased CD4+ T cells, decreased CD21+ and γδhigh T cells as well as increased CD4+/CD8+ and T/B ratio. Multiple regression analysis indicated that endogamy in calves was associated with increased CD8+ T and CD21+ B lymphocytes, and decreased γδhigh T cells in peripheral blood. Cows with medium and lower endogamy had a lower percentage of B lymphocytes and γδlow T cells and cows with lower endogamy had higher levels of γδ T cells and γδhigh T cells, as well as the CD4+/CD48+ cell ratio. Calves with higher endogamy had higher levels of CD8+ T lymphocytes, whereas calves with lower endogamy had lower levels of γδlow T cells. Conclusions: These results demonstrated for the first time that endogamy influences the immune system of cattle.EndogamyCattlemtDNAFlow cytometryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/9533/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINAL2014_095.pdf2014_095.pdfapplication/pdf394714https://www.arca.fiocruz.br/bitstream/icict/9533/2/2014_095.pdf1e6267f1b3ca1696d3d4dd860e6f057fMD52TEXT2014_095.pdf.txt2014_095.pdf.txtExtracted texttext/plain36001https://www.arca.fiocruz.br/bitstream/icict/9533/3/2014_095.pdf.txta291511827b0accf6350d48c74cd3d2bMD53icict/95332022-02-03 11:33:50.633oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-02-03T14:33:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
title Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
spellingShingle Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
Macedo, Auricélio Alves de
Endogamy
Cattle
mtDNA
Flow cytometry
title_short Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
title_full Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
title_fullStr Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
title_full_unstemmed Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
title_sort Influence of endogamy and mitochondrial DNA on immunological parameters in cattle
author Macedo, Auricélio Alves de
author_facet Macedo, Auricélio Alves de
Bittar, Joely Ferreira Figueiredo
Bassi, Paula Boeira
Ronda, Juliano Bergamo
Bittar, Eustáquio Rezende
Paneto, João Cláudio do Carmo
Araújo, Márcio Sobreira Silva
Santos, Renato de Lima
Martins Filho, Olindo Assis
author_role author
author2 Bittar, Joely Ferreira Figueiredo
Bassi, Paula Boeira
Ronda, Juliano Bergamo
Bittar, Eustáquio Rezende
Paneto, João Cláudio do Carmo
Araújo, Márcio Sobreira Silva
Santos, Renato de Lima
Martins Filho, Olindo Assis
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Macedo, Auricélio Alves de
Bittar, Joely Ferreira Figueiredo
Bassi, Paula Boeira
Ronda, Juliano Bergamo
Bittar, Eustáquio Rezende
Paneto, João Cláudio do Carmo
Araújo, Márcio Sobreira Silva
Santos, Renato de Lima
Martins Filho, Olindo Assis
dc.subject.en.pt_BR.fl_str_mv Endogamy
Cattle
mtDNA
Flow cytometry
topic Endogamy
Cattle
mtDNA
Flow cytometry
description Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brazil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-02-23T15:40:24Z
dc.date.available.fl_str_mv 2015-02-23T15:40:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACEDO, Auricélio Alves de et al. Influence of endogamy and mitochondrial DNA on immunological parameters in cattle. BMC Veterinary Research, v. 10, p. 79, 2014
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9533
dc.identifier.issn.none.fl_str_mv 1746-6148
dc.identifier.doi.none.fl_str_mv 10.1186/1746-6148-10-79
identifier_str_mv MACEDO, Auricélio Alves de et al. Influence of endogamy and mitochondrial DNA on immunological parameters in cattle. BMC Veterinary Research, v. 10, p. 79, 2014
1746-6148
10.1186/1746-6148-10-79
url https://www.arca.fiocruz.br/handle/icict/9533
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central Ltd.
publisher.none.fl_str_mv BioMed Central Ltd.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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