Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors

Detalhes bibliográficos
Autor(a) principal: Donnadieu, Emmanuel
Data de Publicação: 2020
Outros Autores: Dupré, Loïc, Pinho, Lia Gonçalves, Almeida, Vinicius Cotta de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/45548
Resumo: Université de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104. Paris, France.
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spelling Donnadieu, EmmanuelDupré, LoïcPinho, Lia GonçalvesAlmeida, Vinicius Cotta de2021-01-10T14:54:06Z2021-01-10T14:54:06Z2020DONNADIEU, Emmanuel et al. Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors. Journal of Leukocyte Biology, v. 108, p. 1067-1079, 2020.1938-3673https://www.arca.fiocruz.br/handle/icict/4554810.1002/JLB.1MR0520-746RengWiley Online LibraryImunoterapia contra o câncerTráfico de células TEngenharia de receptor de antígeno quiméricoMotilidadeMatriz extracelularMicroambiente tumoralCancer immunotherapyT cell traffickingChimeric antigen receptor engineeringMotilityExtracellular matrixTumor microenvironmentSurmounting the obstacles that impede effective CAR Tcell trafficking to solid tumorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversité de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104. Paris, France.INSERM, UMR1043, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France / CNRS, UMR5282. Toulouse, France / Université Toulouse III Paul-Sabatier, Toulouse, France.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Imunomodulação. Rio de Janeiro, RJ, Brasil.Innovative immunotherapies based on immune checkpoint targeting antibodies and engineered T cells are transforming the way we approach cancer treatment. However, although these T cell centered strategies result in marked and durable responses in patients across many different tumor types, they provide therapeutic efficacy only in a proportion of patients. A major challenge of immuno-oncology is thereby to identify mechanisms responsible for resistance to cancer immunotherapy in order to overcome them via adapted strategies thatwill ultimately improve intrinsic efficacy and response rates. Here, we focus on the barriers that restrain the trafficking of chimeric antigen receptor (CAR)-expressing T cells to solid tumors. Upon infusion, CAR T cells need to home into malignant sites, navigate within complex tumor environments, form productive interactions with cancer cells, deliver their cytotoxic activities, and finally persist.We review the accumulating evidence that the microenvironment of solid tumors contains multiple obstacles that hinder CAR T cells in the dynamic steps underlying their trafficking.We focus on how these hurdles may in part account for the failure of CAR T cell clinical trials in human carcinomas. Given the engineered nature of CAR T cells and possibilities to modify the tumor environment, there are ample opportunities to augment CAR T cell ability to efficiently find and combat tumors.We present some of these strategies, which represent a dynamic field of research with high potential for clinical applicability.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45548/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALViniciusCotta_Almeida_etal_IOC_2020.pdfViniciusCotta_Almeida_etal_IOC_2020.pdfapplication/pdf876304https://www.arca.fiocruz.br/bitstream/icict/45548/2/ViniciusCotta_Almeida_etal_IOC_2020.pdf7c2e711875ba5f9756a2ecd6bdecfe49MD52TEXTViniciusCotta_Almeida_etal_IOC_2020.pdf.txtViniciusCotta_Almeida_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
title Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
spellingShingle Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
Donnadieu, Emmanuel
Imunoterapia contra o câncer
Tráfico de células T
Engenharia de receptor de antígeno quimérico
Motilidade
Matriz extracelular
Microambiente tumoral
Cancer immunotherapy
T cell trafficking
Chimeric antigen receptor engineering
Motility
Extracellular matrix
Tumor microenvironment
title_short Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
title_full Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
title_fullStr Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
title_full_unstemmed Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
title_sort Surmounting the obstacles that impede effective CAR Tcell trafficking to solid tumors
author Donnadieu, Emmanuel
author_facet Donnadieu, Emmanuel
Dupré, Loïc
Pinho, Lia Gonçalves
Almeida, Vinicius Cotta de
author_role author
author2 Dupré, Loïc
Pinho, Lia Gonçalves
Almeida, Vinicius Cotta de
author2_role author
author
author
dc.contributor.author.fl_str_mv Donnadieu, Emmanuel
Dupré, Loïc
Pinho, Lia Gonçalves
Almeida, Vinicius Cotta de
dc.subject.other.pt_BR.fl_str_mv Imunoterapia contra o câncer
Tráfico de células T
Engenharia de receptor de antígeno quimérico
Motilidade
Matriz extracelular
Microambiente tumoral
topic Imunoterapia contra o câncer
Tráfico de células T
Engenharia de receptor de antígeno quimérico
Motilidade
Matriz extracelular
Microambiente tumoral
Cancer immunotherapy
T cell trafficking
Chimeric antigen receptor engineering
Motility
Extracellular matrix
Tumor microenvironment
dc.subject.en.pt_BR.fl_str_mv Cancer immunotherapy
T cell trafficking
Chimeric antigen receptor engineering
Motility
Extracellular matrix
Tumor microenvironment
description Université de Paris, Institut Cochin, INSERM, U1016, CNRS, UMR8104. Paris, France.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-01-10T14:54:06Z
dc.date.available.fl_str_mv 2021-01-10T14:54:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DONNADIEU, Emmanuel et al. Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors. Journal of Leukocyte Biology, v. 108, p. 1067-1079, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/45548
dc.identifier.issn.pt_BR.fl_str_mv 1938-3673
dc.identifier.doi.none.fl_str_mv 10.1002/JLB.1MR0520-746R
identifier_str_mv DONNADIEU, Emmanuel et al. Surmounting the obstacles that impede effective CAR T cell trafficking to solid tumors. Journal of Leukocyte Biology, v. 108, p. 1067-1079, 2020.
1938-3673
10.1002/JLB.1MR0520-746R
url https://www.arca.fiocruz.br/handle/icict/45548
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley Online Library
publisher.none.fl_str_mv Wiley Online Library
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/45548/2/ViniciusCotta_Almeida_etal_IOC_2020.pdf
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