Antibody evasion by the P.1 strain of SARS-CoV-2

Detalhes bibliográficos
Autor(a) principal: Dejnirattisai, Wanwisa
Data de Publicação: 2021
Outros Autores: Zhou, Daming, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Gimm, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E, Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, López-Camacho, César, Slon-Campos, Jose, Walter, Thomas S., Skelly, Donal, Clemens, Sue Ann Costa, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Costa, Cristiano Fernandes da, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda Agudo Mendonça Teixeira de, Dold, Christina, Levin -, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah C., Caroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Paterson, Neil G., Williams, Mark A., Hall, David R., Hulswit, Ruben J.G., Bowden, Thomas A, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/47923
Resumo: A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/
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spelling Dejnirattisai, WanwisaZhou, DamingSupasa, PiyadaLiu, ChangMentzer, Alexander J.Gimm, Helen M.Zhao, YuguangDuyvesteyn, Helen M.ETuekprakhon, AekkachaiNutalai, RungtiwaWang, BeibeiLópez-Camacho, CésarSlon-Campos, JoseWalter, Thomas S.Skelly, DonalClemens, Sue Ann CostaNaveca, Felipe GomesNascimento, ValdineteNascimento, FernandaCosta, Cristiano Fernandes daResende, Paola CristinaPauvolid-Correa, AlexSiqueira, Marilda Agudo Mendonça Teixeira deDold, ChristinaLevin -, RobertDong, TaoPollard, Andrew J.Knight, Julian C.Crook, DerrickLambe, TeresaClutterbuck, ElizabethBibi, SagidaFlaxman, AmyBittaye, MustaphaBelij-Rammerstorfer, SandraGilbert, Sarah C.Caroll, Miles W.Klenerman, PaulBarnes, EleanorDunachie, Susanna J.Paterson, Neil G.Williams, Mark A.Hall, David R.Hulswit, Ruben J.G.Bowden, Thomas AFry, Elizabeth E.Mongkolsapaya, JuthathipRen, JingshanStuart, David I.Screaton, Gavin R.2021-06-30T12:42:00Z2021-06-30T12:42:00Z2021DEJNIRATTISAI, Wanwisa et al. Antibody evasion by the P.1 strain of SARS-CoV-2. Cell, n. 184, p. 2939-2954, May 2021.1525-0016https://www.arca.fiocruz.br/handle/icict/4792310.1016/j.cell.2021.03.055A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Division of Structural Biology. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK / University of Oxford. Chinese Academy of Medical Science (CAMS) Oxford Institute (COI). Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK / Oxford University Hospitals NHS Foundation Trust. Oxford, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus. Didcot, UK.University of Oxford. Nuffield Department of Medicine. Division of Structural Biology. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Division of Structural Biology. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Division of Structural Biology. The Wellcome Centre for Human Genetics. Oxford, UK.Oxford University Hospitals NHS Foundation Trust. Oxford, UK / Peter Medawar Building for Pathogen Research. Oxford, UK / University of Oxford. Nuffield Department of Clinical Neurosciences. Oxford, UK.University of Siena. Institute of Global Health. Department of Paediatrics. Siena, Italia / University of Oxford. Oxford, UK.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Laboratório de Ecologia de Doenças Transmissíveis na Amazônia. Manaus, AM, Brasil.Fundação de Vigilância em Saúde do Amazonas. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil / Texas A&M University. College Station. Department of Veterinary Integrative Biosciences. TX, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratório e do Sarampo. Rio de Janeiro, RJ, Brasil.NIHR Oxford Biomedical Research Centre. Oxford, UK / University of Oxford. Oxford Vaccine Group. Department of Paediatrics. Oxford, UK.Worthing Hospital. Worthing, UK.University of Oxford. Chinese Academy of Medical Science. Oxford Institute. Oxford, UK / University of Oxford, Radcliffe Department of Medicine. MRC Human Immunology Unit. MRC Weatherall Institute of Molecular Medicine. Oxford, UK / University of Oxford. Nuffield Department of Medicine. Oxford, UK.NIHR Oxford Biomedical Research Centre. Oxford, UK / University of Oxford. Department of Paediatrics. Oxford Vaccine Group. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK / University of Oxford. Chinese Academy of Medical Science. Oxford Institute. Oxford, UK / University of Oxford. Nuffield Department of Medicine. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Oxford, UK.University of Oxford. Jenner Institute. Nuffield Department of Medicine. Oxford, UK.NIHR Oxford Biomedical Research Centre. Oxford, UK / University of Oxford. Department of Paediatrics. Oxford Vaccine Group. Oxford, UK.NIHR Oxford Biomedical Research Centre. Oxford, UK / University of Oxford. Department of Paediatrics. Oxford Vaccine Group. Oxford, UK.University of Oxford. Jenner Institute. Nuffield Department of Medicine. Oxford, UK.University of Oxford. Jenner Institute. Nuffield Department of Medicine. Oxford, UK.University of Oxford. Jenner Institute. Nuffield Department of Medicine. Oxford, UK.University of Oxford. Jenner Institute. Nuffield Department of Medicine. Oxford, UK.University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK / National Infection Service. Public Health England Porton Down, Salisbury, UK.National Infection Service. Public Health England. Porton Down, Salisbury, UK / Peter Medawar Building for Pathogen Research. Oxford, UK / NIHR Oxford Biomedical Research Centre. Oxford, UK / University of Oxford. Translational Gastroenterology Unit. Oxford, UK.National Infection Service. Public Health England. Porton Down, Salisbury, UK / Peter Medawar Building for Pathogen Research. Oxford, UK / NIHR Oxford Biomedical Research Centre. Oxford, UK / University of Oxford. Translational Gastroenterology Unit. Oxford, UK.Oxford University Hospitals NHS Foundation Trust. Oxford, UK / Peter Medawar Building for Pathogen Research. Oxford, UK / University of Oxford. Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine. Oxford, UK / University of Oxford. Mahidol-Oxford Tropical Medicine Research Unit, Bangkok Thailand, Department of Medicine. Oxford, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus. Didcot, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus. Didcot, UK.Diamond Light Source Ltd, Harwell Science & Innovation Campus. Didcot, UK.University of Oxford. Division of Structural Biology. Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Division of Structural Biology. Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Division of Structural Biology. Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Division of Structural Biology. Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK / University of Oxford. Chinese Academy of Medical Science. Oxford Institute. Oxford, UK / Siriraj Center of Research Excellence in Dengue & Emerging Pathogens. Dean Office for Research, Faculty of Medicine Siriraj Hospital. Mahidol University. Thailand.University of Oxford. Division of Structural Biology. Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK.University of Oxford. Division of Structural Biology. Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK / University of Oxford. Division of Structural Biology, Nuffield Department of Medicine. The Wellcome Centre for Human Genetics. Oxford, UK / University of Oxford, Oxford Institute. Chinese Academy of Medical Science. Oxford, UK / Diamond Light Source Ltd, Harwell Science & Innovation Campus. Didcot, UK / Instruct-ERIC, Oxford House Parkway. Court John Smith Drive. Oxford, UK .University of Oxford. Nuffield Department of Medicine. Wellcome Centre for Human Genetics. Oxford, UK / University of Oxford. Oxford Institute. Chinese Academy of Medical Science. Oxford, UK.Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutral izing antibody responses to the virus spike derived from early isolates. However, new strains have emerged with multiple mutations, including P.1 from Brazil, B.1.351 from South Africa, and B.1.1.7 from the UK (12, 10, and 9 changes in the spike, respectively). All have mutations in the ACE2 binding site, with P.1 and B.1.351 having a virtually identical triplet (E484K, K417N/T, and N501Y), which we show confer similar increased af finity for ACE2. We show that, surprisingly, P.1 is significantly less resistant to naturally acquired or vaccine induced antibody responses than B.1.351, suggesting that changes outside the receptor-binding domain (RBD) impact neutralization. Monoclonal antibody (mAb) 222 neutralizes all three variants despite interacting with two of the ACE2-binding site mutations. We explain this through structural analysis and use the 222 light chain to largely restore neutralization potency to a major class of public antibodiesengCell PressSARS-CoV-2Evasão de anticorposcepa P.1COVID-19Rede Genômica FiocruzGENOMAHCOVSARS-CoV-2P.1 strainAntibody evasionCOVID-19Antibody evasion by the P.1 strain of SARS-CoV-2info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Antibody evasion by the P.1 strain of SARS-CoV-2
title Antibody evasion by the P.1 strain of SARS-CoV-2
spellingShingle Antibody evasion by the P.1 strain of SARS-CoV-2
Dejnirattisai, Wanwisa
SARS-CoV-2
Evasão de anticorpos
cepa P.1
COVID-19
Rede Genômica Fiocruz
GENOMAHCOV
SARS-CoV-2
P.1 strain
Antibody evasion
COVID-19
title_short Antibody evasion by the P.1 strain of SARS-CoV-2
title_full Antibody evasion by the P.1 strain of SARS-CoV-2
title_fullStr Antibody evasion by the P.1 strain of SARS-CoV-2
title_full_unstemmed Antibody evasion by the P.1 strain of SARS-CoV-2
title_sort Antibody evasion by the P.1 strain of SARS-CoV-2
author Dejnirattisai, Wanwisa
author_facet Dejnirattisai, Wanwisa
Zhou, Daming
Supasa, Piyada
Liu, Chang
Mentzer, Alexander J.
Gimm, Helen M.
Zhao, Yuguang
Duyvesteyn, Helen M.E
Tuekprakhon, Aekkachai
Nutalai, Rungtiwa
Wang, Beibei
López-Camacho, César
Slon-Campos, Jose
Walter, Thomas S.
Skelly, Donal
Clemens, Sue Ann Costa
Naveca, Felipe Gomes
Nascimento, Valdinete
Nascimento, Fernanda
Costa, Cristiano Fernandes da
Resende, Paola Cristina
Pauvolid-Correa, Alex
Siqueira, Marilda Agudo Mendonça Teixeira de
Dold, Christina
Levin -, Robert
Dong, Tao
Pollard, Andrew J.
Knight, Julian C.
Crook, Derrick
Lambe, Teresa
Clutterbuck, Elizabeth
Bibi, Sagida
Flaxman, Amy
Bittaye, Mustapha
Belij-Rammerstorfer, Sandra
Gilbert, Sarah C.
Caroll, Miles W.
Klenerman, Paul
Barnes, Eleanor
Dunachie, Susanna J.
Paterson, Neil G.
Williams, Mark A.
Hall, David R.
Hulswit, Ruben J.G.
Bowden, Thomas A
Fry, Elizabeth E.
Mongkolsapaya, Juthathip
Ren, Jingshan
Stuart, David I.
Screaton, Gavin R.
author_role author
author2 Zhou, Daming
Supasa, Piyada
Liu, Chang
Mentzer, Alexander J.
Gimm, Helen M.
Zhao, Yuguang
Duyvesteyn, Helen M.E
Tuekprakhon, Aekkachai
Nutalai, Rungtiwa
Wang, Beibei
López-Camacho, César
Slon-Campos, Jose
Walter, Thomas S.
Skelly, Donal
Clemens, Sue Ann Costa
Naveca, Felipe Gomes
Nascimento, Valdinete
Nascimento, Fernanda
Costa, Cristiano Fernandes da
Resende, Paola Cristina
Pauvolid-Correa, Alex
Siqueira, Marilda Agudo Mendonça Teixeira de
Dold, Christina
Levin -, Robert
Dong, Tao
Pollard, Andrew J.
Knight, Julian C.
Crook, Derrick
Lambe, Teresa
Clutterbuck, Elizabeth
Bibi, Sagida
Flaxman, Amy
Bittaye, Mustapha
Belij-Rammerstorfer, Sandra
Gilbert, Sarah C.
Caroll, Miles W.
Klenerman, Paul
Barnes, Eleanor
Dunachie, Susanna J.
Paterson, Neil G.
Williams, Mark A.
Hall, David R.
Hulswit, Ruben J.G.
Bowden, Thomas A
Fry, Elizabeth E.
Mongkolsapaya, Juthathip
Ren, Jingshan
Stuart, David I.
Screaton, Gavin R.
author2_role author
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author
author
dc.contributor.author.fl_str_mv Dejnirattisai, Wanwisa
Zhou, Daming
Supasa, Piyada
Liu, Chang
Mentzer, Alexander J.
Gimm, Helen M.
Zhao, Yuguang
Duyvesteyn, Helen M.E
Tuekprakhon, Aekkachai
Nutalai, Rungtiwa
Wang, Beibei
López-Camacho, César
Slon-Campos, Jose
Walter, Thomas S.
Skelly, Donal
Clemens, Sue Ann Costa
Naveca, Felipe Gomes
Nascimento, Valdinete
Nascimento, Fernanda
Costa, Cristiano Fernandes da
Resende, Paola Cristina
Pauvolid-Correa, Alex
Siqueira, Marilda Agudo Mendonça Teixeira de
Dold, Christina
Levin -, Robert
Dong, Tao
Pollard, Andrew J.
Knight, Julian C.
Crook, Derrick
Lambe, Teresa
Clutterbuck, Elizabeth
Bibi, Sagida
Flaxman, Amy
Bittaye, Mustapha
Belij-Rammerstorfer, Sandra
Gilbert, Sarah C.
Caroll, Miles W.
Klenerman, Paul
Barnes, Eleanor
Dunachie, Susanna J.
Paterson, Neil G.
Williams, Mark A.
Hall, David R.
Hulswit, Ruben J.G.
Bowden, Thomas A
Fry, Elizabeth E.
Mongkolsapaya, Juthathip
Ren, Jingshan
Stuart, David I.
Screaton, Gavin R.
dc.subject.other.pt_BR.fl_str_mv SARS-CoV-2
Evasão de anticorpos
cepa P.1
COVID-19
Rede Genômica Fiocruz
GENOMAHCOV
topic SARS-CoV-2
Evasão de anticorpos
cepa P.1
COVID-19
Rede Genômica Fiocruz
GENOMAHCOV
SARS-CoV-2
P.1 strain
Antibody evasion
COVID-19
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
P.1 strain
Antibody evasion
COVID-19
description A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-06-30T12:42:00Z
dc.date.available.fl_str_mv 2021-06-30T12:42:00Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DEJNIRATTISAI, Wanwisa et al. Antibody evasion by the P.1 strain of SARS-CoV-2. Cell, n. 184, p. 2939-2954, May 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/47923
dc.identifier.issn.pt_BR.fl_str_mv 1525-0016
dc.identifier.doi.none.fl_str_mv 10.1016/j.cell.2021.03.055
identifier_str_mv DEJNIRATTISAI, Wanwisa et al. Antibody evasion by the P.1 strain of SARS-CoV-2. Cell, n. 184, p. 2939-2954, May 2021.
1525-0016
10.1016/j.cell.2021.03.055
url https://www.arca.fiocruz.br/handle/icict/47923
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/47923/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/47923/2/MarildaSiqueira_PRezende_etal_IOC_2021.pdf
https://www.arca.fiocruz.br/bitstream/icict/47923/4/_AUTORIZACAO_DEPOSITO_ARCA_REDE_GENOMICA.pdf
https://www.arca.fiocruz.br/bitstream/icict/47923/3/MarildaSiqueira_PRezende_etal_IOC_2021.pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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