The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target

Detalhes bibliográficos
Autor(a) principal: Bezerra, Rômulo J. Soares
Data de Publicação: 2015
Outros Autores: Pinho, Rosa T., Bisaggio, Rodrigo da C., Andrade, Thereza Christina Benévolo de, Alves, Luiz A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14391
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
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spelling Bezerra, Rômulo J. SoaresPinho, Rosa T.Bisaggio, Rodrigo da C.Andrade, Thereza Christina Benévolo deAlves, Luiz A.2016-05-19T13:49:16Z2016-05-19T13:49:16Z2015BEZERRA, Rômulo J. Soares; et al. The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target. Cell Physiol Biochem., v.37, n.2, p.409-418, 2015.1015-8987https://www.arca.fiocruz.br/handle/icict/1439110.1159/0004303641421-9778engKargerThe Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Targetinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Treatment for tuberculosis is effective with the use of proper antibiotics, but the number of drug-resistant cases is increasing. Drug resistance occurred in 650,000 cases of the 20 million patients in treatment worldwide in 2011, which demonstrates the necessity of finding new therapeutic approaches. In this context, the search for new medicines and immunomodulators could help reduce the prevalence and incidence of multi-drug-resistant tuberculosis cases. Thus several preclinical studies demonstrate the involvement of the P2X7 receptor (P2X7R) in the control of Mycobacterium tuberculosis (MTB) infection. Adenosine triphosphate (ATP), a natural agonist for P2X7R, promotes MTB death and the induction of apoptosis in monocytes and macrophages infected with MTB via activation of P2X7R by extracellular ATP. In addition, P2X7R activation in the presence of ATP increases the expression of major histocompatibility complex (MHC) class II by macrophages infected with Mycobacterium bovis (BCG) or MTB, which contributes to the generation of the antimicrobial immune response via T cells. Nevertheless, one idea that seems overlooked by the “purinergic community” is the use of the high-conductance channel associated with P2X7R to increase the passage of hydrophilic drugs to the cytoplasm of cells that express the P2X7 pore, a potential method for a drug delivery system. In this work, we propose the use of P2X7 agonists in conjunction with low molecular weight anti-tuberculosis medicines for the treatment of multi-drug-resistant tuberculosis.AgonistsP2X7RPurinergic ReceptorsMultidrug ResistanceTuberculosisTuberculoseResistência a MedicamentosAgonistasReceptores Purinérgicosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14391/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALromulo2_bezerra_etal_IOC_2015.pdfromulo2_bezerra_etal_IOC_2015.pdfapplication/pdf1671006https://www.arca.fiocruz.br/bitstream/icict/14391/2/romulo2_bezerra_etal_IOC_2015.pdfa42f82af8922708ebe9470ae107a86bfMD52TEXTromulo2_bezerra_etal_IOC_2015.pdf.txtromulo2_bezerra_etal_IOC_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
title The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
spellingShingle The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
Bezerra, Rômulo J. Soares
Agonists
P2X7R
Purinergic Receptors
Multidrug Resistance
Tuberculosis
Tuberculose
Resistência a Medicamentos
Agonistas
Receptores Purinérgicos
title_short The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
title_full The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
title_fullStr The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
title_full_unstemmed The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
title_sort The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target
author Bezerra, Rômulo J. Soares
author_facet Bezerra, Rômulo J. Soares
Pinho, Rosa T.
Bisaggio, Rodrigo da C.
Andrade, Thereza Christina Benévolo de
Alves, Luiz A.
author_role author
author2 Pinho, Rosa T.
Bisaggio, Rodrigo da C.
Andrade, Thereza Christina Benévolo de
Alves, Luiz A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bezerra, Rômulo J. Soares
Pinho, Rosa T.
Bisaggio, Rodrigo da C.
Andrade, Thereza Christina Benévolo de
Alves, Luiz A.
dc.subject.en.pt_BR.fl_str_mv Agonists
P2X7R
Purinergic Receptors
Multidrug Resistance
Tuberculosis
topic Agonists
P2X7R
Purinergic Receptors
Multidrug Resistance
Tuberculosis
Tuberculose
Resistência a Medicamentos
Agonistas
Receptores Purinérgicos
dc.subject.decs.pt_BR.fl_str_mv Tuberculose
Resistência a Medicamentos
Agonistas
Receptores Purinérgicos
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-05-19T13:49:16Z
dc.date.available.fl_str_mv 2016-05-19T13:49:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BEZERRA, Rômulo J. Soares; et al. The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target. Cell Physiol Biochem., v.37, n.2, p.409-418, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14391
dc.identifier.issn.none.fl_str_mv 1015-8987
dc.identifier.doi.none.fl_str_mv 10.1159/000430364
dc.identifier.eissn.none.fl_str_mv 1421-9778
identifier_str_mv BEZERRA, Rômulo J. Soares; et al. The Search for New Agonists to P2X7R for Clinical Use: Tuberculosis as a Possible Target. Cell Physiol Biochem., v.37, n.2, p.409-418, 2015.
1015-8987
10.1159/000430364
1421-9778
url https://www.arca.fiocruz.br/handle/icict/14391
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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