Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Cavalcante, S. C.
Data de Publicação: 2010
Outros Autores: Durovni, B., Barnes, G. L., Souza, F. B. A., Silva, R. F., Barroso, P. F., Mohan, C. I., Miller, A., Golub, J. E., Chaisson, R. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37531
Resumo: 2020-06-03
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spelling Cavalcante, S. C.Durovni, B.Barnes, G. L.Souza, F. B. A.Silva, R. F.Barroso, P. F.Mohan, C. I.Miller, A.Golub, J. E.Chaisson, R. E.2019-12-03T12:38:03Z2019-12-03T12:38:03Z2010CAVALCANTE, S. C. et al. Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease, v. 14, n. 2, p. 203-209, Feb. 2010.1027-3719https://www.arca.fiocruz.br/handle/icict/375311815-7920engInternational Union Against Tuberculosis and Lung DiseaseCommunity-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-03Municipal Health Secretariat. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Municipal Health Secretariat. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. School of Medicine. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, Rio de Janeiro, RJ, Brazil.Johns Hopkins University. Center for Tuberculosis Research. Departments of Medicine, Epidemiology and International Health. Baltimore, MD, USA.Municipal Health Secretariat. Rio de Janeiro, RJ, Brazil / Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Municipal Health Secretariat. Rio de Janeiro, RJ, Brazil.Universidade Federal do Rio de Janeiro. School of Medicine. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, Rio de Janeiro, RJ, Brazil.Johns Hopkins University. Center for Tuberculosis Research. Departments of Medicine, Epidemiology and International Health. Baltimore, MD, USA.Johns Hopkins University. Center for Tuberculosis Research. Departments of Medicine, Epidemiology and International Health. Baltimore, MD, USA.Johns Hopkins University. Center for Tuberculosis Research. Departments of Medicine, Epidemiology and International Health. Baltimore, MD, USA.Johns Hopkins University. Center for Tuberculosis Research. Departments of Medicine, Epidemiology and International Health. Baltimore, MD, USA.SETTING: Central Rio de Janeiro, Brazil. OBJECTIVE: To compare the impact of routine DOTS vs. enhanced DOTS (DOTS-Ampliado or DOTS-A) on tuberculosis (TB) incidence. DESIGN: Cluster-randomized trial in eight urban neighborhoods pair-matched by TB incidence and randomly assigned to receive either the DOTS-A or DOTS strategy. DOTS-A added intensive screening of household contacts of active TB cases and provision of treatment to secondary cases and preventive therapy to contacts with latent TB infection (LTBI) to the standard DOTS strategy. The primary endpoint was the TB incidence rates in communities after 5 years of intervention. RESULTS—From November 2000 to December 2004, respectively 339 and 311 pulmonary TB cases were enrolled and 1003 and 960 household were identified in DOTS and DOTS-A communities. Among contacts from DOTS-A communities, 26 (4%) had active TB diagnosed and treated, 429 (61.3%) had LTBI detected and 258 (60.1%) started preventive therapy. TB incidence increased by 5% in DOTS communities and decreased by 10% in DOTS-A communities, for a difference of 15% after 5 years (P = 0.04). CONCLUSION: DOTS-A was associated with a modest reduction in TB incidence and may be an important strategy for reducing the burden of TB.TuberculosisDOTSHousehold contactsLatent TB infection treatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37531/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Cavalcante_S_etal_INI_2010.pdfve_Cavalcante_S_etal_INI_2010.pdfapplication/pdf204437https://www.arca.fiocruz.br/bitstream/icict/37531/2/ve_Cavalcante_S_etal_INI_2010.pdfa0c90e53da561282a66680f2b6ba8eafMD52TEXTve_Cavalcante_S_etal_INI_2010.pdf.txtve_Cavalcante_S_etal_INI_2010.pdf.txtExtracted texttext/plain32253https://www.arca.fiocruz.br/bitstream/icict/37531/3/ve_Cavalcante_S_etal_INI_2010.pdf.txtb04ecab66bbd3d6ae637dba5c4ffdd75MD53icict/375312021-03-24 16:32:32.737oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
title Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
spellingShingle Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
Cavalcante, S. C.
Tuberculosis
DOTS
Household contacts
Latent TB infection treatment
title_short Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
title_full Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
title_fullStr Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
title_full_unstemmed Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
title_sort Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil
author Cavalcante, S. C.
author_facet Cavalcante, S. C.
Durovni, B.
Barnes, G. L.
Souza, F. B. A.
Silva, R. F.
Barroso, P. F.
Mohan, C. I.
Miller, A.
Golub, J. E.
Chaisson, R. E.
author_role author
author2 Durovni, B.
Barnes, G. L.
Souza, F. B. A.
Silva, R. F.
Barroso, P. F.
Mohan, C. I.
Miller, A.
Golub, J. E.
Chaisson, R. E.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cavalcante, S. C.
Durovni, B.
Barnes, G. L.
Souza, F. B. A.
Silva, R. F.
Barroso, P. F.
Mohan, C. I.
Miller, A.
Golub, J. E.
Chaisson, R. E.
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
DOTS
Household contacts
Latent TB infection treatment
topic Tuberculosis
DOTS
Household contacts
Latent TB infection treatment
description 2020-06-03
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2019-12-03T12:38:03Z
dc.date.available.fl_str_mv 2019-12-03T12:38:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CAVALCANTE, S. C. et al. Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease, v. 14, n. 2, p. 203-209, Feb. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37531
dc.identifier.issn.pt_BR.fl_str_mv 1027-3719
dc.identifier.eissn.none.fl_str_mv 1815-7920
identifier_str_mv CAVALCANTE, S. C. et al. Community-randomized trial of enhanced DOTS for tuberculosis control in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease, v. 14, n. 2, p. 203-209, Feb. 2010.
1027-3719
1815-7920
url https://www.arca.fiocruz.br/handle/icict/37531
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv International Union Against Tuberculosis and Lung Disease
publisher.none.fl_str_mv International Union Against Tuberculosis and Lung Disease
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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