CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7829 |
Resumo: | Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil |
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Pinheiro, Melina de BarrosAntonelli, Lis Ribeiro do ValleAvelar, Renato SathlerAvelar, Danielle Marquete VitelliMiranda, Silvana Spindola deGuimarães, Tânia Mara Pinto DabésCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisToledo, Vicente de Paulo Coelho Peixoto de2014-06-18T17:38:47Z2014-06-18T17:38:47Z2012PINHEIRO, Melina de Barros et al. CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis. Plos One. 2012, vol.7, pp. 509231932-6203https://www.arca.fiocruz.br/handle/icict/782910.1371/journal.pone.0050923engPublic Library of Science oneCD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Clínica Médica. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, BrasilT-cells play an important role controlling immunity against pathogens and therefore influence the outcome of human diseases. Although most T-lymphocytes co-express either CD4 or CD8, a smaller T-cell subset found the in the human peripheral blood that expresses the αβ or γδ T-cell-receptor (TCR) lacks the CD4 and CD8 co-receptors. These double negative (DN) T-cells have been shown to display important immunological functions in human diseases. To better understand the role of DN T-cells in human Mycobacterium tuberculosis, we have characterized their frequency, activation and cytokine profile in a well-defined group of tuberculosis patients, categorized as severe and non-severe based on their clinical status. Our data showed that whereas high frequency of αβ DN T-cells observed in M. tuberculosis-infected patients are associated with disease severity, decreased proportion of γδ DN T-cells are found in patients with severe tuberculosis. Together with activation of CD4+ and CD8+ T-cells, higher frequencies of both αβ and γδ DN T-cells from tuberculosis patients also express the chronic activation marker HLA-DR. However, the expression of CD69, an early activation marker, is selectively observed in DN T-cells. Interestingly, while αβ and γδ DN T-cells from patients with non-severe tuberculosis display a pro-inflammatory cytokine profile, characterized by enhanced IFN-γ, the γδ DN T-cells from patients with severe disease express a modulatory profile exemplified by enhanced interleukin-10 production. Overall, our findings suggest that αβ and γδ DN T-cell present disparate immunoregulatory potentials and seems to contribute to the development/maintenance of distinct clinical aspects of TB, as part of the complex immunological network triggered by the TB infection.Mycobacterium tuberculosisT-cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCD4-CD8-pdf.pdfCD4-CD8-pdf.pdfapplication/pdf1930409https://www.arca.fiocruz.br/bitstream/icict/7829/1/CD4-CD8-pdf.pdfaa60749bc01161834122704f2f8d68e9MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7829/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCD4-CD8-pdf.pdf.txtCD4-CD8-pdf.pdf.txtExtracted texttext/plain10https://www.arca.fiocruz.br/bitstream/icict/7829/5/CD4-CD8-pdf.pdf.txt2c6eb67c8897d916ae47524b1a844d3fMD55THUMBNAILCD4-CD8-pdf.pdf.jpgCD4-CD8-pdf.pdf.jpgGenerated Thumbnailimage/jpeg2187https://www.arca.fiocruz.br/bitstream/icict/7829/4/CD4-CD8-pdf.pdf.jpg160fd57000599a15318c911dc99f40c4MD54icict/78292018-04-05 23:45:45.001oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T02:45:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| title |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| spellingShingle |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis Pinheiro, Melina de Barros Mycobacterium tuberculosis T-cells |
| title_short |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| title_full |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| title_fullStr |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| title_full_unstemmed |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| title_sort |
CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis |
| author |
Pinheiro, Melina de Barros |
| author_facet |
Pinheiro, Melina de Barros Antonelli, Lis Ribeiro do Valle Avelar, Renato Sathler Avelar, Danielle Marquete Vitelli Miranda, Silvana Spindola de Guimarães, Tânia Mara Pinto Dabés Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Toledo, Vicente de Paulo Coelho Peixoto de |
| author_role |
author |
| author2 |
Antonelli, Lis Ribeiro do Valle Avelar, Renato Sathler Avelar, Danielle Marquete Vitelli Miranda, Silvana Spindola de Guimarães, Tânia Mara Pinto Dabés Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Toledo, Vicente de Paulo Coelho Peixoto de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pinheiro, Melina de Barros Antonelli, Lis Ribeiro do Valle Avelar, Renato Sathler Avelar, Danielle Marquete Vitelli Miranda, Silvana Spindola de Guimarães, Tânia Mara Pinto Dabés Carvalho, Andréa Teixeira de Martins Filho, Olindo Assis Toledo, Vicente de Paulo Coelho Peixoto de |
| dc.subject.en.pt_BR.fl_str_mv |
Mycobacterium tuberculosis T-cells |
| topic |
Mycobacterium tuberculosis T-cells |
| description |
Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil |
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2012 |
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2012 |
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2014-06-18T17:38:47Z |
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2014-06-18T17:38:47Z |
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PINHEIRO, Melina de Barros et al. CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis. Plos One. 2012, vol.7, pp. 50923 |
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10.1371/journal.pone.0050923 |
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PINHEIRO, Melina de Barros et al. CD4-CD8-αβ and γδ T cells display inflammatory and regulatory potentials during human tuberculosis. Plos One. 2012, vol.7, pp. 50923 1932-6203 10.1371/journal.pone.0050923 |
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