The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital

Detalhes bibliográficos
Autor(a) principal: Provenzano, Bruna Cuoco
Data de Publicação: 2021
Outros Autores: Bartholo, Thiago, Ribeiro-Alves, Marcelo, Santos, Ana Paula Gomes dos, Mafort, Thiago Thomaz, Castro, Marcos Cesar Santos de, Oliveira, Jose Gustavo Pugliese de, Bruno, Leonardo Palermo, Lopes, Agnaldo José, Costa, Claudia Henrique da, Rufino, Rogerio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50449
Resumo: Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.
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spelling Provenzano, Bruna CuocoBartholo, ThiagoRibeiro-Alves, MarceloSantos, Ana Paula Gomes dosMafort, Thiago ThomazCastro, Marcos Cesar Santos deOliveira, Jose Gustavo Pugliese deBruno, Leonardo PalermoLopes, Agnaldo JoséCosta, Claudia Henrique daRufino, Rogerio2021-12-15T16:24:07Z2021-12-15T16:24:07Z2021PROVENZANO, Bruna Cuoco et al. The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital. Revista da Associacao Medica Brasileira, v. 67, n. 7, p. 997-1002, 20210104-4230https://www.arca.fiocruz.br/handle/icict/5044910.1590/1806-9282.20210433engScieloThe impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospitalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Objective: This study aims to analyze the risk factors for in-hospital mortality in a cohort of patients admitted to a newly adapted intensive care unit in a public hospital in Rio de Janeiro. Methods: This was an observational, retrospective, and descriptive study. Data were obtained from electronic medical records. Coronavirus disease 2019 (COVID-19) was diagnosed by detecting viral ribonucleic acid using reverse transcription polymerase chain reaction. Factors associated with the risk/protection from death were determined using the odds ratio and adjusted odds ratio. Results: Fifty-one patients were admitted to the hospital. The median age of the patients was 63 years, 60% were male patients, and 54% were white patients. Sixty-seven percent of the patients were diagnosed with COVID-19. Sepsis at admission increased the chance of in-hospital death by 21 times (adjusted odds ratio=21.06 [0.79-555.2]; p=0.06). The strongest risk factor for death was the development of septic shock during hospitalization (adjusted odds ratio=98.56 [2.75-352.5]; p=0.01), and one in four patients had multidrug-resistant bacteria. Mechanical ventilation, vasopressors, neuromuscular blockers, and sedatives were also the risk factors for in-hospital mortality. The in-hospital mortality rate was 41%, and the mortality rate of patients on mechanical ventilation was 60%. The diagnosis of COVID-19 was not statistically related to the adverse outcomes. Conclusions: In this cohort, the strongest risk factor for in-hospital death was the development of nosocomial septic shock. Healthcare-associated infections have a significant impact on mortality rates. Therefore, to have a better outcome, it is important to consider not only the availability of beds but also the way healthcare is delivered.SARS-CoV-2COVID-19Healthcare associated infectionMortalityPatient safetyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/50449/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALThe impact_Marcelo_Alves_etal_INI_2021.pdfThe impact_Marcelo_Alves_etal_INI_2021.pdfapplication/pdf192516https://www.arca.fiocruz.br/bitstream/icict/50449/2/The%20impact_Marcelo_Alves_etal_INI_2021.pdfc6d81957b606aed940a99b797d5f902cMD52icict/504492021-12-15 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dc.title.pt_BR.fl_str_mv The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
title The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
spellingShingle The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
Provenzano, Bruna Cuoco
SARS-CoV-2
COVID-19
Healthcare associated infection
Mortality
Patient safety
title_short The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
title_full The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
title_fullStr The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
title_full_unstemmed The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
title_sort The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital
author Provenzano, Bruna Cuoco
author_facet Provenzano, Bruna Cuoco
Bartholo, Thiago
Ribeiro-Alves, Marcelo
Santos, Ana Paula Gomes dos
Mafort, Thiago Thomaz
Castro, Marcos Cesar Santos de
Oliveira, Jose Gustavo Pugliese de
Bruno, Leonardo Palermo
Lopes, Agnaldo José
Costa, Claudia Henrique da
Rufino, Rogerio
author_role author
author2 Bartholo, Thiago
Ribeiro-Alves, Marcelo
Santos, Ana Paula Gomes dos
Mafort, Thiago Thomaz
Castro, Marcos Cesar Santos de
Oliveira, Jose Gustavo Pugliese de
Bruno, Leonardo Palermo
Lopes, Agnaldo José
Costa, Claudia Henrique da
Rufino, Rogerio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Provenzano, Bruna Cuoco
Bartholo, Thiago
Ribeiro-Alves, Marcelo
Santos, Ana Paula Gomes dos
Mafort, Thiago Thomaz
Castro, Marcos Cesar Santos de
Oliveira, Jose Gustavo Pugliese de
Bruno, Leonardo Palermo
Lopes, Agnaldo José
Costa, Claudia Henrique da
Rufino, Rogerio
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
Healthcare associated infection
Mortality
Patient safety
topic SARS-CoV-2
COVID-19
Healthcare associated infection
Mortality
Patient safety
description Universidade do Estado do Rio de Janeiro. Departamento de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-15T16:24:07Z
dc.date.available.fl_str_mv 2021-12-15T16:24:07Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PROVENZANO, Bruna Cuoco et al. The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital. Revista da Associacao Medica Brasileira, v. 67, n. 7, p. 997-1002, 2021
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50449
dc.identifier.issn.pt_BR.fl_str_mv 0104-4230
dc.identifier.doi.none.fl_str_mv 10.1590/1806-9282.20210433
identifier_str_mv PROVENZANO, Bruna Cuoco et al. The impact of healthcare-associated infections on COVID-19 mortality: a cohort study from a Brazilian public hospital. Revista da Associacao Medica Brasileira, v. 67, n. 7, p. 997-1002, 2021
0104-4230
10.1590/1806-9282.20210433
url https://www.arca.fiocruz.br/handle/icict/50449
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scielo
publisher.none.fl_str_mv Scielo
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50449/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50449/2/The%20impact_Marcelo_Alves_etal_INI_2021.pdf
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