Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43644 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil |
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Miranda, Vitor Hugo SimõesGomes, Talita RochaEller, Dirli EmerickFerraz, Lorena de Cássia NeresChaves, Ana TherezaBicalho, Kelly AlvesSilva, Carlos Eduardo CalzavaraBirbrair, AlexanderXavier, Marcelo Antônio PascoalGoes, Alfredo Miranda deOliveira, Rodrigo Corrêa deAlves, Érica Alessandra RochaBozzi, Adriana2020-09-28T13:29:07Z2020-09-28T13:29:07Z2020MIRANDA, Vitor Hugo Simoes et al. Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment. PLoS Negl Trop Dis, v. 14, n. 8, e0008635. https://doi.org/10.1371/journal.pntd.00086351935-2727https://www.arca.fiocruz.br/handle/icict/4364410.1371/journal.pntd.0008635engPublic Library of ScienceLiver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil/ Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilInstituto René Rachou, Fiocruz Minas, Belo Horizonte, Minas Gerais, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/Universidade Estadual de Santa Cruz. Departamento de Ciências Biológicas. Ilhéus, BA, BrazilBackground: In view of the potential immunosuppressive and regenerative properties of mesenchymal stem cells (MSC), we investigated whether transplantation of adipose tissue-derived stem cells (ASC) could be used to control the granulomatous reaction in the liver of mice infected with Schistosoma mansoni after Praziquantel (PZQ) treatment. Methodology/Prinicpal findings: C57BL/6 mice infected with S. mansoni were treated with PZQ and transplanted intravenously with ASC from uninfected mice. Liver morpho-physiological and immunological analyses were performed. The combined PZQ/ASC therapy significantly reduced the volume of hepatic granulomas, as well as liver damage as measured by ALT levels. We also observed that ASC accelerated the progression of the granulomatous inflammation to the advanced/curative phase. The faster healing interfered with the expression of CD28 and CTLA-4 molecules in CD4+ T lymphocytes, and the levels of IL-10 and IL-17 cytokines, mainly in the livers of PZQ/ASC-treated mice. Conclusions: Our results show that ASC therapy after PZQ treatment results in smaller granulomas with little tissue damage, suggesting the potential of ASC for the development of novel therapeutic approaches to minimize hepatic lesions as well as a granulomatous reaction following S. mansoni infection. Further studies using the chronic model of schistosomiasis are required to corroborate the therapeutic use of ASC for schistosomiasis.GranulomasStem cell therapyCytokinesSchistosoma mansoniMesenchymal stem cellsSchistosomiasisCytokine therapyEggsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/43644/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALLiver damage in schistosomiasis.pdfLiver damage in schistosomiasis.pdfapplication/pdf3711225https://www.arca.fiocruz.br/bitstream/icict/43644/2/Liver%20damage%20in%20schistosomiasis.pdfb690cd3ed04d580ae5060be5ac2b84d9MD52TEXTLiver damage in schistosomiasis.pdf.txtLiver damage in schistosomiasis.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| title |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| spellingShingle |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment Miranda, Vitor Hugo Simões Granulomas Stem cell therapy Cytokines Schistosoma mansoni Mesenchymal stem cells Schistosomiasis Cytokine therapy Eggs |
| title_short |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| title_full |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| title_fullStr |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| title_full_unstemmed |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| title_sort |
Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment |
| author |
Miranda, Vitor Hugo Simões |
| author_facet |
Miranda, Vitor Hugo Simões Gomes, Talita Rocha Eller, Dirli Emerick Ferraz, Lorena de Cássia Neres Chaves, Ana Thereza Bicalho, Kelly Alves Silva, Carlos Eduardo Calzavara Birbrair, Alexander Xavier, Marcelo Antônio Pascoal Goes, Alfredo Miranda de Oliveira, Rodrigo Corrêa de Alves, Érica Alessandra Rocha Bozzi, Adriana |
| author_role |
author |
| author2 |
Gomes, Talita Rocha Eller, Dirli Emerick Ferraz, Lorena de Cássia Neres Chaves, Ana Thereza Bicalho, Kelly Alves Silva, Carlos Eduardo Calzavara Birbrair, Alexander Xavier, Marcelo Antônio Pascoal Goes, Alfredo Miranda de Oliveira, Rodrigo Corrêa de Alves, Érica Alessandra Rocha Bozzi, Adriana |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Miranda, Vitor Hugo Simões Gomes, Talita Rocha Eller, Dirli Emerick Ferraz, Lorena de Cássia Neres Chaves, Ana Thereza Bicalho, Kelly Alves Silva, Carlos Eduardo Calzavara Birbrair, Alexander Xavier, Marcelo Antônio Pascoal Goes, Alfredo Miranda de Oliveira, Rodrigo Corrêa de Alves, Érica Alessandra Rocha Bozzi, Adriana |
| dc.subject.en.pt_BR.fl_str_mv |
Granulomas Stem cell therapy Cytokines Schistosoma mansoni Mesenchymal stem cells Schistosomiasis Cytokine therapy Eggs |
| topic |
Granulomas Stem cell therapy Cytokines Schistosoma mansoni Mesenchymal stem cells Schistosomiasis Cytokine therapy Eggs |
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Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil |
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2020 |
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2020-09-28T13:29:07Z |
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2020-09-28T13:29:07Z |
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2020 |
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MIRANDA, Vitor Hugo Simoes et al. Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment. PLoS Negl Trop Dis, v. 14, n. 8, e0008635. https://doi.org/10.1371/journal.pntd.0008635 |
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https://www.arca.fiocruz.br/handle/icict/43644 |
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1935-2727 |
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10.1371/journal.pntd.0008635 |
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MIRANDA, Vitor Hugo Simoes et al. Liver damage in schistosomiasis is reduced by adipose tissue-derived stem cell therapy after praziquantel treatment. PLoS Negl Trop Dis, v. 14, n. 8, e0008635. https://doi.org/10.1371/journal.pntd.0008635 1935-2727 10.1371/journal.pntd.0008635 |
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