Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test

Detalhes bibliográficos
Autor(a) principal: Legey, Ana Paula
Data de Publicação: 1999
Outros Autores: Pinho, Ana Paula S., Xavier, Samanta C. Chagas, Leon, Leonor L., Jansen, Ana Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/37213
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
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spelling Legey, Ana PaulaPinho, Ana Paula S.Xavier, Samanta C. ChagasLeon, Leonor L.Jansen, Ana Maria2019-11-21T12:10:32Z2019-11-21T12:10:32Z1999LEGEY, Ana Paula et al. Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 371-376, May/June 1999.0074-0206https://www.arca.fiocruz.br/handle/icict/3721310.1590/s0074-027619990003000161678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTrypanosma cruziPhilander opossumDidelphis marsupialisImunoglobulinaTrypanosma cruziPhilander opossumDidelphis marsupialisImmunoglobulinsHumoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody testinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Rio de Janeiro, RJ, Brasil.Philander opossum and Didelphis marsupialis considered the most ancient mammals and an evolutionary success, maintain parasitism by Trypanosoma cruzi without developing any apparent disease or important tissue lesion. In order to elucidate this well-balanced interaction, we decided to compare the humoral immune response kinetics of the two didelphids naturally and experimentally infected with T. cruzi and immunized by different schedules of parasite antigens, employing an indirect fluorescence antibody test (IFAT). Both didelphids responded with high serological titers to different immunization routes, while the earliest response occurred with the intradermic route. Serological titers of naturally infected P. opossum showed a significant individual variation, while those of D. marsupialis remained stable during the entire follow-up period. The serological titers of the experimentally infected animals varied according to the inoculated strain. Our data suggest that (1) IFAT was sensitive for follow-up of P. opossum in natural and experimental T. cruzi infections; (2) both P. opossum and D. marsupialis are able to mount an efficient humoral immune response as compared to placental mammals; (3) experimentally infected P. opossum and D. marsupialis present distinct patterns of infection, depending on the subpopulation of T. cruzi, (4) the differences observed in the humoral immune responses between P. opossum and D. marsupialis, probably, reflect distinct strategies selected by these animals during their coevolution with T. cruzi.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en.fl_str_mv Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
title Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
spellingShingle Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
Legey, Ana Paula
Trypanosma cruzi
Philander opossum
Didelphis marsupialis
Imunoglobulina
Trypanosma cruzi
Philander opossum
Didelphis marsupialis
Immunoglobulins
title_short Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
title_full Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
title_fullStr Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
title_full_unstemmed Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
title_sort Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test
author Legey, Ana Paula
author_facet Legey, Ana Paula
Pinho, Ana Paula S.
Xavier, Samanta C. Chagas
Leon, Leonor L.
Jansen, Ana Maria
author_role author
author2 Pinho, Ana Paula S.
Xavier, Samanta C. Chagas
Leon, Leonor L.
Jansen, Ana Maria
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Legey, Ana Paula
Pinho, Ana Paula S.
Xavier, Samanta C. Chagas
Leon, Leonor L.
Jansen, Ana Maria
dc.subject.other.pt_BR.fl_str_mv Trypanosma cruzi
Philander opossum
Didelphis marsupialis
Imunoglobulina
topic Trypanosma cruzi
Philander opossum
Didelphis marsupialis
Imunoglobulina
Trypanosma cruzi
Philander opossum
Didelphis marsupialis
Immunoglobulins
dc.subject.en.en.fl_str_mv Trypanosma cruzi
Philander opossum
Didelphis marsupialis
Immunoglobulins
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2019-11-21T12:10:32Z
dc.date.available.fl_str_mv 2019-11-21T12:10:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEGEY, Ana Paula et al. Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 371-376, May/June 1999.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/37213
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/s0074-02761999000300016
dc.identifier.eissn.pt_BR.fl_str_mv 1678-8060
identifier_str_mv LEGEY, Ana Paula et al. Humoral immune response kinetics in Philander opossum and Didelphis marsupialis infected and immunized by Trypanosoma cruzi employing an immunofluorescence antibody test. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 94, n. 3, p. 371-376, May/June 1999.
0074-0206
10.1590/s0074-02761999000300016
1678-8060
url https://www.arca.fiocruz.br/handle/icict/37213
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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