Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37110 |
Resumo: | Universidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Martins, Liline Maria SoaresWanke, BodoLazéra, Márcia dos SantosTrilles, LucianaBarbosa, Gláucia GonçalvesMacedo, Regina Célia LimaCavalcanti, Maria do Amparo SalmitoEulálio, Kelsen DantasCastro, José Adail FonsecaSilva, Adalberto SocorroNascimento, Fernando FerrazGouveia, Viviane AlvesMonte, Semiramis Jamil Hadad2019-11-18T13:37:58Z2019-11-18T13:37:58Z2011MARTINS, Liline Maria Soares et al. Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 6, p. 725-730, Sept. 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/3711010.1590/S0074-027620110006000121678-8060engInstituto Oswaldo Cruz, Ministério da SaúdeGenotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Micologia. Rio de Janeiro, RJ, Brasil.Instituto de Doenças Tropicais Natan Portella. Teresina, PI, Brasil.Instituto de Doenças Tropicais Natan Portella. Teresina, PI, Brasil.Universidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Microbiologia. Belo Horizonte, MG, Brasil.Universidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil.Throughout Brazil, Cryptococcus neoformans is the cause of cryptococcosis, whereas Cryptococcus gattii is endemic to the northern and northeastern states. In this study, the molecular types of 63 cryptococcal isolates recovered from the cerebrospinal fluid of meningitis patients diagnosed between 2008-2010 in Teresina, Piauí, Brazil, were analysed. Out of the 63 patients, 37 (58.7%) were human immunodeficiency virus (HIV)-positive and 26 (41.3%) were HIV-negative. URA5-restriction fragment length polymorphism analysis identified 37/63 (58.7%) isolates as the C. neoformans VNI genotype, predominantly in HIV-positive patients (32/37, 86.5%), and 24/63 (38.1%) as the C. gattii VGII genotype, mostly in HIV-negative patients (21/26, 80.8%). The occurrence of C. gattii VGII in six apparently healthy children and in seven adolescents/young adults in this region reaffirms the endemic occurrence of C. gattii VGII-induced primary cryptococcosis and early cryptococcal infection. Lethality occurred in 18/37 (48.6%) of the HIV-positive subjects and in 13/26 (50%) of the HIV-negative patients. Our results provide new information on the molecular epidemiology of C. neoformans and C. gattii in Brazilian endemic areas.Cryptococcus gattiiCryptococcus neoformansGenotypesEndemic mycosesChildrenImmunocompetent hostinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37110/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Martins_Liline_etal_INI_2011.pdfve_Martins_Liline_etal_INI_2011.pdfapplication/pdf364836https://www.arca.fiocruz.br/bitstream/icict/37110/2/ve_Martins_Liline_etal_INI_2011.pdf457a644413f78104ffca823bc75c6cc0MD52TEXTve_Martins_Liline_etal_INI_2011.pdf.txtve_Martins_Liline_etal_INI_2011.pdf.txtExtracted texttext/plain31527https://www.arca.fiocruz.br/bitstream/icict/37110/3/ve_Martins_Liline_etal_INI_2011.pdf.txtb7d38a0bcfb6382eedd0503420e59ac8MD53icict/371102019-11-19 14:57:22.928oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-11-19T17:57:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| title |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| spellingShingle |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) Martins, Liline Maria Soares Cryptococcus gattii Cryptococcus neoformans Genotypes Endemic mycoses Children Immunocompetent host |
| title_short |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| title_full |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| title_fullStr |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| title_full_unstemmed |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| title_sort |
Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil) |
| author |
Martins, Liline Maria Soares |
| author_facet |
Martins, Liline Maria Soares Wanke, Bodo Lazéra, Márcia dos Santos Trilles, Luciana Barbosa, Gláucia Gonçalves Macedo, Regina Célia Lima Cavalcanti, Maria do Amparo Salmito Eulálio, Kelsen Dantas Castro, José Adail Fonseca Silva, Adalberto Socorro Nascimento, Fernando Ferraz Gouveia, Viviane Alves Monte, Semiramis Jamil Hadad |
| author_role |
author |
| author2 |
Wanke, Bodo Lazéra, Márcia dos Santos Trilles, Luciana Barbosa, Gláucia Gonçalves Macedo, Regina Célia Lima Cavalcanti, Maria do Amparo Salmito Eulálio, Kelsen Dantas Castro, José Adail Fonseca Silva, Adalberto Socorro Nascimento, Fernando Ferraz Gouveia, Viviane Alves Monte, Semiramis Jamil Hadad |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Martins, Liline Maria Soares Wanke, Bodo Lazéra, Márcia dos Santos Trilles, Luciana Barbosa, Gláucia Gonçalves Macedo, Regina Célia Lima Cavalcanti, Maria do Amparo Salmito Eulálio, Kelsen Dantas Castro, José Adail Fonseca Silva, Adalberto Socorro Nascimento, Fernando Ferraz Gouveia, Viviane Alves Monte, Semiramis Jamil Hadad |
| dc.subject.en.pt_BR.fl_str_mv |
Cryptococcus gattii Cryptococcus neoformans Genotypes Endemic mycoses Children Immunocompetent host |
| topic |
Cryptococcus gattii Cryptococcus neoformans Genotypes Endemic mycoses Children Immunocompetent host |
| description |
Universidade Federal do Piauí. Laboratório de Imunogenética e Biologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2011 |
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2011 |
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2019-11-18T13:37:58Z |
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2019-11-18T13:37:58Z |
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info:eu-repo/semantics/article |
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MARTINS, Liline Maria Soares et al. Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 6, p. 725-730, Sept. 2011. |
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https://www.arca.fiocruz.br/handle/icict/37110 |
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0074-0276 |
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10.1590/S0074-02762011000600012 |
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1678-8060 |
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MARTINS, Liline Maria Soares et al. Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 6, p. 725-730, Sept. 2011. 0074-0276 10.1590/S0074-02762011000600012 1678-8060 |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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Instituto Oswaldo Cruz, Ministério da Saúde |
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