Complement system activation is a plasma biomarker signature during Malaria in pregnancy
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60735 |
Resumo: | Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. |
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Santiago, Veronica FeijoliDombrowski, Jamille GregorioKawahara, RebecaRosa-Fernandes, LiviaMule, Simon NgaoMurillo, OscarSantana, Thais ViggianiCoutinho, Joao Victor PacciniMacedo-da-Silva, JanainaLazari, Lucas CardosoPeixoto, Erika Paula MachadoRamirez, Marcel IvanLarsen, Martin R.Marinho, Cláudio Romero FariasPalmisano, Giuseppe2023-10-09T14:23:29Z2023-10-09T14:23:29Z2023SANTIAGO, Veronica Feijoli et al. Complement system activation is a plasma biomarker signature during Malaria in pregnancy. Genes. v. 14, n. 1624, p. 1-20, 2023.2073-4425https://www.arca.fiocruz.br/handle/icict/60735porMDPIComplement system activation is a plasma biomarker signature during Malaria in pregnancyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. / Analytical Glycoimmunology Group. Department of Molecular Sciences. Macquarie University. Macquarie Park, Australia.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. / Department of Pulmonary Immunology. Center for Biomedical Research. University of Texas Health Center Science at Tyler. Tyler, USA.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brasil.Department of Biochemistry and Molecular Biology. University of Southern Denmark. Odense, Denmark.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil.Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. / Analytical Glycoimmunology Group. Department of Molecular Sciences. Macquarie University. Macquarie Park, Australia.Malaria in pregnancy (MiP) is a public health problem in malaria-endemic areas, contributing to detrimental outcomes for both mother and fetus. Primigravida and second-time mothers are most affected by severe anemia complications and babies with low birth weight compared to multigravida women. Infected erythrocytes (IE) reach the placenta, activating the immune response by placental monocyte infiltration and inflammation. However, specific markers of MiP result in poor outcomes, such as low birth weight, and intrauterine growth restriction for babies and maternal anemia in women infected with Plasmodium falciparum are limited. In this study, we identified the plasma proteome signature of a mouse model infected with Plasmodium berghei ANKA and pregnant women infected with Plasmodium falciparum infection using quantitative mass spectrometry-based proteomics. A total of 279 and 249 proteins were quantified in murine and human plasma samples, of which 28% and 30% were regulated proteins, respectively. Most of the regulated proteins in both organisms are involved in complement system activation during malaria in pregnancy. CBA anaphylatoxin assay confirmed the complement system activation by the increase in C3a and C4a anaphylatoxins in the infected plasma compared to non-infected plasma. Moreover, correlation analysis showed the association between complement system activation and reduced head circumference in newborns from Pf-infected mothers. The data obtained in this study highlight the correlation between the complement system and immune and newborn outcomes resulting from malaria in pregnancy.MalariaPregnancy Complications, ParasiticComplement System ProteinsBiomarkersComplicaciones Parasitarias del EmbarazoProteínas del Sistema ComplementoBiomarcadoresPaludismeComplications parasitaires de la grossesseProtéines du système du complémentMarqueurs biologiquesMaláriaComplicações Parasitárias na GravidezPlasmodium bergheiPlasmodium falciparumProteínas do Sistema ComplementoBiomarcadoresPlasmainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
title |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
spellingShingle |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy Santiago, Veronica Feijoli Malaria Pregnancy Complications, Parasitic Complement System Proteins Biomarkers Complicaciones Parasitarias del Embarazo Proteínas del Sistema Complemento Biomarcadores Paludisme Complications parasitaires de la grossesse Protéines du système du complément Marqueurs biologiques Malária Complicações Parasitárias na Gravidez Plasmodium berghei Plasmodium falciparum Proteínas do Sistema Complemento Biomarcadores Plasma |
title_short |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
title_full |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
title_fullStr |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
title_full_unstemmed |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
title_sort |
Complement system activation is a plasma biomarker signature during Malaria in pregnancy |
author |
Santiago, Veronica Feijoli |
author_facet |
Santiago, Veronica Feijoli Dombrowski, Jamille Gregorio Kawahara, Rebeca Rosa-Fernandes, Livia Mule, Simon Ngao Murillo, Oscar Santana, Thais Viggiani Coutinho, Joao Victor Paccini Macedo-da-Silva, Janaina Lazari, Lucas Cardoso Peixoto, Erika Paula Machado Ramirez, Marcel Ivan Larsen, Martin R. Marinho, Cláudio Romero Farias Palmisano, Giuseppe |
author_role |
author |
author2 |
Dombrowski, Jamille Gregorio Kawahara, Rebeca Rosa-Fernandes, Livia Mule, Simon Ngao Murillo, Oscar Santana, Thais Viggiani Coutinho, Joao Victor Paccini Macedo-da-Silva, Janaina Lazari, Lucas Cardoso Peixoto, Erika Paula Machado Ramirez, Marcel Ivan Larsen, Martin R. Marinho, Cláudio Romero Farias Palmisano, Giuseppe |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santiago, Veronica Feijoli Dombrowski, Jamille Gregorio Kawahara, Rebeca Rosa-Fernandes, Livia Mule, Simon Ngao Murillo, Oscar Santana, Thais Viggiani Coutinho, Joao Victor Paccini Macedo-da-Silva, Janaina Lazari, Lucas Cardoso Peixoto, Erika Paula Machado Ramirez, Marcel Ivan Larsen, Martin R. Marinho, Cláudio Romero Farias Palmisano, Giuseppe |
dc.subject.en.en_US.fl_str_mv |
Malaria Pregnancy Complications, Parasitic Complement System Proteins Biomarkers |
topic |
Malaria Pregnancy Complications, Parasitic Complement System Proteins Biomarkers Complicaciones Parasitarias del Embarazo Proteínas del Sistema Complemento Biomarcadores Paludisme Complications parasitaires de la grossesse Protéines du système du complément Marqueurs biologiques Malária Complicações Parasitárias na Gravidez Plasmodium berghei Plasmodium falciparum Proteínas do Sistema Complemento Biomarcadores Plasma |
dc.subject.es.en_US.fl_str_mv |
Complicaciones Parasitarias del Embarazo Proteínas del Sistema Complemento Biomarcadores |
dc.subject.fr.en_US.fl_str_mv |
Paludisme Complications parasitaires de la grossesse Protéines du système du complément Marqueurs biologiques |
dc.subject.decs.en_US.fl_str_mv |
Malária Complicações Parasitárias na Gravidez Plasmodium berghei Plasmodium falciparum Proteínas do Sistema Complemento Biomarcadores Plasma |
description |
Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo, SP, Brasil. |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-10-09T14:23:29Z |
dc.date.available.fl_str_mv |
2023-10-09T14:23:29Z |
dc.date.issued.fl_str_mv |
2023 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTIAGO, Veronica Feijoli et al. Complement system activation is a plasma biomarker signature during Malaria in pregnancy. Genes. v. 14, n. 1624, p. 1-20, 2023. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/60735 |
dc.identifier.issn.en_US.fl_str_mv |
2073-4425 |
identifier_str_mv |
SANTIAGO, Veronica Feijoli et al. Complement system activation is a plasma biomarker signature during Malaria in pregnancy. Genes. v. 14, n. 1624, p. 1-20, 2023. 2073-4425 |
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https://www.arca.fiocruz.br/handle/icict/60735 |
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