Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15892 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Bello, GonzaloAulicino, Paula C.Ruchansky, DoraGuimarães, Monick L.Lopez-Galindez, CecilioCasado, ConchaChiparelli, HectorRocco, CarlosMangano, AndreaSen, LuisaMorgado, Mariza G.2016-09-21T17:35:28Z2016-09-21T17:35:28Z2010BELLO, Gonzalo; et al. Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay. Retrovirology, v.7:22, 9p, 2010.1742-4690https://www.arca.fiocruz.br/handle/icict/1589210.1186/1742-4690-7-221742-4690engBioMed CentralHIV-1ArgentinaUruguaiAIDSHIV-1ArgentinaUruguayAIDS epidemicPhylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguayinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina.Servicio Nacional de Laboratorios de Salud Publica - MSP. Laboratorio Nacional de Referencia VIH-SIDA. Montevideo, Uruguay.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain.Instituto de Salud Carlos III. Centro Nacional de Microbiología. Servicio de Virologia Molecular. Madrid, Spain.Servicio Nacional de Laboratorios de Salud Publica - MSP. Laboratorio Nacional de Referencia VIH-SIDA. Montevideo, Uruguay.Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina.Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina.Hospital de Pediatría J P Garrahan. Laboratorio de Biología Celular y Retrovirus. CONICET. Buenos Aires, Argentina.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Background: Although HIV-1 CRF12_BF and CRF38_BF are two epidemiologically important recombinant lineages circulating in Argentina and Uruguay, little is known about their population dynamics. Methods: A total of 120 “CRF12_BF-like” and 20 “CRF38_BF-like” pol recombinant sequences collected in Argentina and Uruguay from 1997 to 2009 were subjected to phylogenetic and Bayesian coalescent-based analyses to estimate evolutionary and demographic parameters. Results: Phylogenetic analyses revealed that CRF12_BF viruses from Argentina and Uruguay constitute a single epidemic with multiple genetic exchanges among countries; whereas circulation of the CRF38_BF seems to be confined to Uruguay. The mean estimated substitution rate of CRF12_BF at pol gene (2.5 × 10-3 substitutions/site/ year) was similar to that previously described for subtype B. According to our estimates, CRF12_BF and CRF38_BF originated at 1983 (1978-1988) and 1986 (1981-1990), respectively. After their emergence, the CRF12_BF and CRF38_BF epidemics seem to have experienced a period of rapid expansion with initial growth rates of around 1.2 year-1 and 0.9 year-1, respectively. Later, the rate of spread of these CRFs_BF seems to have slowed down since the mid-1990s. Conclusions: Our results suggest that CRF12_BF and CRF38_BF viruses were generated during the 1980s, shortly after the estimated introduction of subtype F1 in South America (~1975-1980). After an initial phase of fast exponential expansion, the rate of spread of both CRFs_BF epidemics seems to have slowed down, thereby following a demographic pattern that resembles those previously reported for the HIV-1 epidemics in Brazil, USA, and Western Europe.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15892/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo2_bello_etal_IOC-210.pdfgonzalo2_bello_etal_IOC-210.pdfapplication/pdf1144507https://www.arca.fiocruz.br/bitstream/icict/15892/2/gonzalo2_bello_etal_IOC-210.pdfe658fc052d72559eb68132969046d4fdMD52TEXTgonzalo2_bello_etal_IOC-210.pdf.txtgonzalo2_bello_etal_IOC-210.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| title |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| spellingShingle |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay Bello, Gonzalo HIV-1 Argentina Uruguai AIDS HIV-1 Argentina Uruguay AIDS epidemic |
| title_short |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| title_full |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| title_fullStr |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| title_full_unstemmed |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| title_sort |
Phylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguay |
| author |
Bello, Gonzalo |
| author_facet |
Bello, Gonzalo Aulicino, Paula C. Ruchansky, Dora Guimarães, Monick L. Lopez-Galindez, Cecilio Casado, Concha Chiparelli, Hector Rocco, Carlos Mangano, Andrea Sen, Luisa Morgado, Mariza G. |
| author_role |
author |
| author2 |
Aulicino, Paula C. Ruchansky, Dora Guimarães, Monick L. Lopez-Galindez, Cecilio Casado, Concha Chiparelli, Hector Rocco, Carlos Mangano, Andrea Sen, Luisa Morgado, Mariza G. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bello, Gonzalo Aulicino, Paula C. Ruchansky, Dora Guimarães, Monick L. Lopez-Galindez, Cecilio Casado, Concha Chiparelli, Hector Rocco, Carlos Mangano, Andrea Sen, Luisa Morgado, Mariza G. |
| dc.subject.other.pt_BR.fl_str_mv |
HIV-1 Argentina Uruguai AIDS |
| topic |
HIV-1 Argentina Uruguai AIDS HIV-1 Argentina Uruguay AIDS epidemic |
| dc.subject.en.pt_BR.fl_str_mv |
HIV-1 Argentina Uruguay AIDS epidemic |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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2010 |
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2010 |
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2016-09-21T17:35:28Z |
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2016-09-21T17:35:28Z |
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BELLO, Gonzalo; et al. Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay. Retrovirology, v.7:22, 9p, 2010. |
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https://www.arca.fiocruz.br/handle/icict/15892 |
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1742-4690 |
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10.1186/1742-4690-7-22 |
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1742-4690 |
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BELLO, Gonzalo; et al. Phylodynamics of HIV-1 Circulating Recombinant Forms 12_BF and 38_BF in Argentina and Uruguay. Retrovirology, v.7:22, 9p, 2010. 1742-4690 10.1186/1742-4690-7-22 |
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