Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?

Morais, Liliane M.; Paula, Vanessa S. de; Arantes, Milton R.; Oliveira, Maria L. A.; Gaspar, Ana Maria C.

Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?

Detalhes bibliográficos
Autor(a) principal:	Morais, Liliane M.
Data de Publicação:	2006
Outros Autores:	Paula, Vanessa S. de, Arantes, Milton R., Oliveira, Maria L. A., Gaspar, Ana Maria C.
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/39458
Resumo:	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.

Metadados do item

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spelling	Morais, Liliane M.Paula, Vanessa S. deArantes, Milton R.Oliveira, Maria L. A.Gaspar, Ana Maria C.2020-01-23T13:28:50Z2020-01-23T13:28:50Z2006MORAIS, Liliane M. et al. Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: Should attending children under two years of age be vaccinated?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 401-405, June 2006.0074-0206https://www.arca.fiocruz.br/handle/icict/3945810.1590/s0074-027620060004000101678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzAnticorpos contra hepatite ASubgenótipos IA e IB do vírus da hepatite AHepatite AFatores de riscoBrasilHepatitis A antibodiesHepatitis A virus subgenotypes IA and IBHepatitis ARisk factorsBrazilEarly infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Hospital Geral da Santa Casa de Misericórdia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.A cross-sectional study was conducted in order to identify hepatitis A virus (HAV) serological markers in 418 individuals (mean age, 16.4 years; range, 1 month-80 years) at a public child care center in Rio de Janeiro, Brazil, as well as to analyze risk factors and determine circulating genotypes. Serum samples were tested using an enzyme immunoassay. Reverse transcription polymerase chain reaction (RT-PCR) was used to detect and characterize HAV RNA, and sequencing was performed. Anti-HAV antibodies and IgM anti-HAV antibodies were detected, respectively, in 89.5% (374/418) and 10.5% (44/418) of the individuals tested. Acute HAV infection in children was independently correlated with crawling (p < 0.05). In 56.8% (25/44) of the IgM anti-HAV-positive individuals and in 33.3% (5/15) of the IgM anti-HAV-negative individuals presenting clinical symptoms, HAV RNA was detected. Phylogenetic analysis revealed co-circulation of subgenotypes IA and IB in 93.3% (28/30) of the amplified samples. In present study, we verify that 79% (30/38) of children IgM anti-HAV-positive were asymptomatic. In child care centers, this asymptomatic spread is a more serious problem, promoting the infection of young children, who rarely show signs of infection. Therefore, vaccinating children below the age of two might prevent the asymptomatic spread of hepatitis A.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/39458/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLilianeMorais_ANaGaspar_etal_IOC_2006.pdfLilianeMorais_ANaGaspar_etal_IOC_2006.pdfapplication/pdf500569https://www.arca.fiocruz.br/bitstream/icict/39458/2/LilianeMorais_ANaGaspar_etal_IOC_2006.pdf6fd2f75e29aa4f19a5dd83b33bd8192cMD52TEXTLilianeMorais_ANaGaspar_etal_IOC_2006.pdf.txtLilianeMorais_ANaGaspar_etal_IOC_2006.pdf.txtExtracted texttext/plain24015https://www.arca.fiocruz.br/bitstream/icict/39458/3/LilianeMorais_ANaGaspar_etal_IOC_2006.pdf.txt8955cfde56278e7c8eaf2aeb292165e4MD53icict/394582020-01-24 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dc.title.pt_BR.fl_str_mv	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
title	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
spellingShingle	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated? Morais, Liliane M. Anticorpos contra hepatite A Subgenótipos IA e IB do vírus da hepatite A Hepatite A Fatores de risco Brasil Hepatitis A antibodies Hepatitis A virus subgenotypes IA and IB Hepatitis A Risk factors Brazil
title_short	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
title_full	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
title_fullStr	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
title_full_unstemmed	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
title_sort	Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?
author	Morais, Liliane M.
author_facet	Morais, Liliane M. Paula, Vanessa S. de Arantes, Milton R. Oliveira, Maria L. A. Gaspar, Ana Maria C.
author_role	author
author2	Paula, Vanessa S. de Arantes, Milton R. Oliveira, Maria L. A. Gaspar, Ana Maria C.
author2_role	author author author author
dc.contributor.author.fl_str_mv	Morais, Liliane M. Paula, Vanessa S. de Arantes, Milton R. Oliveira, Maria L. A. Gaspar, Ana Maria C.
dc.subject.other.pt_BR.fl_str_mv	Anticorpos contra hepatite A Subgenótipos IA e IB do vírus da hepatite A Hepatite A Fatores de risco Brasil
topic	Anticorpos contra hepatite A Subgenótipos IA e IB do vírus da hepatite A Hepatite A Fatores de risco Brasil Hepatitis A antibodies Hepatitis A virus subgenotypes IA and IB Hepatitis A Risk factors Brazil
dc.subject.en.pt_BR.fl_str_mv	Hepatitis A antibodies Hepatitis A virus subgenotypes IA and IB Hepatitis A Risk factors Brazil
description	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.
publishDate	2006
dc.date.issued.fl_str_mv	2006
dc.date.accessioned.fl_str_mv	2020-01-23T13:28:50Z
dc.date.available.fl_str_mv	2020-01-23T13:28:50Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	MORAIS, Liliane M. et al. Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: Should attending children under two years of age be vaccinated?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 401-405, June 2006.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/39458
dc.identifier.issn.pt_BR.fl_str_mv	0074-0206
dc.identifier.doi.none.fl_str_mv	10.1590/s0074-02762006000400010
dc.identifier.eissn.none.fl_str_mv	1678-8060
identifier_str_mv	MORAIS, Liliane M. et al. Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: Should attending children under two years of age be vaccinated?. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 101, n. 4, p. 401-405, June 2006. 0074-0206 10.1590/s0074-02762006000400010 1678-8060
url	https://www.arca.fiocruz.br/handle/icict/39458
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv	Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
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reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
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Early infection and asymptomatic spread of hepatitis A virus in a public child care center in Rio de Janeiro, Brazil: should attending children under two years of age be vaccinated?

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