Highly expressed placental miRNAs control key biological processes in human cancer cell lines

Detalhes bibliográficos
Autor(a) principal: Vidal, Daniel Onofre
Data de Publicação: 2018
Outros Autores: Ramão, Anelisa, Pinheiro, Daniel Guariz, Muys, Bruna Rodrigues, Lorenzi, Julio Cesar Cetrulo, Alves, Cleidson de Pádua, Zanette, Dalila Lucíola, Molfetta, Greice Andreotti de, Duarte, Geraldo, Silva Junior, Wilson Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30638
Resumo: ZANETTE, Dalila Lucíola. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Vidal, Daniel OnofreRamão, AnelisaPinheiro, Daniel GuarizMuys, Bruna RodriguesLorenzi, Julio Cesar CetruloAlves, Cleidson de PáduaZanette, Dalila LucíolaMolfetta, Greice Andreotti deDuarte, GeraldoSilva Junior, Wilson Araújo2018-12-17T17:26:51Z2018-12-17T17:26:51Z2018VIDAL, Daniel Onofre et al. Highly expressed placental miRNAs control key biological processes in human cancer cell lines. Oncotarget, v. 9, n. 34, p. 23554-23563, 2018.1949-2553https://www.arca.fiocruz.br/handle/icict/30638ZANETTE, Dalila Lucíola. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / Barretos Cancer Hospital. Molecular Oncology Research Center. Barretos, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil.Ribeirão Preto Medical School, University of São Paulo. Department of Gynecology and Obstetrics. Ribeirão Preto, SP, Brazil.University of São Paulo. Ribeirão Preto Medical School. Department of Genetics. Ribeirão Preto, SP, Brazil / National Institute of Science and Technology in Stem Cell and Cell Therapy. Center for Cell-Based Therapy. Riberão Preto, SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Center for Medical Genomics. Ribeirão , SP, Brazil / University of São Paulo. Ribeirão Preto Medical School. Center for Integrative Systems Biology. Ribeirão Preto, SP, Brazil.Despite being a healthy tissue, the constituent cells of the placenta, share similar characteristics with tumor cells, such as increased cell growth, migration, and invasion. However, while these processes are stochastic and uncontrolled in cancer cells, in placenta they are precisely controlled. Since miRNAs have been reported to regulate genes that control the molecular mechanisms necessary for the development of both human placenta and cancer, we addressed for miRNAs highly expressed in the placenta that could be involved in tumorigenesis. Here, we assessed the miRNA profile in placenta samples using microarray analysis. The results showed that miR-451 and miR-720, highly expressed placental miRNAs, presented very low or undetectable expression in cancer cell lines compared to the normal placenta and healthy tissues. Additionally, transfection of miR-451 or miR-720 mimics in choriocarcinoma cell line (JEG3) and colorectal adenocarcinoma cell line (HT-29) resulted in impaired cell proliferation, decreased cell migration and invasion and reduced ability of colony formation. These findings provide evidence that placenta may work as an alternative model to identify novel miRNAs involved in pathways controlling tumorigenesis.engImpact JournalsCancerPlacentaCélulas tumoraisTumorigêneseHumanosCancerPlacentaNeoplastic CellsCarcinogenesisHumansHighly expressed placental miRNAs control key biological processes in human cancer cell linesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30638/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVidal DO. Highly expressed placental miRNAs controls...2018.pdfVidal DO. Highly expressed placental miRNAs controls...2018.pdfapplication/pdf3159669https://www.arca.fiocruz.br/bitstream/icict/30638/2/Vidal%20DO.%20Highly%20expressed%20placental%20miRNAs%20controls...2018.pdf660994933b3b6b4dff9323164fdbeee3MD52TEXTVidal DO. Highly expressed placental miRNAs controls...2018.pdf.txtVidal DO. Highly expressed placental miRNAs controls...2018.pdf.txtExtracted texttext/plain39677https://www.arca.fiocruz.br/bitstream/icict/30638/3/Vidal%20DO.%20Highly%20expressed%20placental%20miRNAs%20controls...2018.pdf.txt1f2a3e35ed9ad08b932a6ad6bd65bb6cMD53icict/306382023-03-15 14:34:16.036oai:www.arca.fiocruz.br:icict/30638Q0VTU8ODTyBOw4NPIEVYQ0xVU0lWQSBERSBESVJFSVRPUyBBVVRPUkFJUwoKQW8gYWNlaXRhciBvcyBURVJNT1MgZSBDT05EScOHw5VFUyBkZXN0YSBDRVNTw4NPLCBvIEFVVE9SIGUvb3UgVElUVUxBUiBkZSBkaXJlaXRvcwphdXRvcmFpcyBzb2JyZSBhIE9CUkEgZGUgcXVlIHRyYXRhIGVzdGUgZG9jdW1lbnRvOgoKKDEpIENFREUgZSBUUkFOU0ZFUkUsIHRvdGFsIGUgZ3JhdHVpdGFtZW50ZSwgw6AgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaLCBlbQpjYXLDoXRlciBwZXJtYW5lbnRlLCBpcnJldm9nw6F2ZWwgZSBOw4NPIEVYQ0xVU0lWTywgdG9kb3Mgb3MgZGlyZWl0b3MgcGF0cmltb25pYWlzIE7Dg08KQ09NRVJDSUFJUyBkZSB1dGlsaXphw6fDo28gZGEgT0JSQSBhcnTDrXN0aWNhIGUvb3UgY2llbnTDrWZpY2EgaW5kaWNhZGEgYWNpbWEsIGluY2x1c2l2ZSBvcyBkaXJlaXRvcwpkZSB2b3ogZSBpbWFnZW0gdmluY3VsYWRvcyDDoCBPQlJBLCBkdXJhbnRlIHRvZG8gbyBwcmF6byBkZSBkdXJhw6fDo28gZG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBlbQpxdWFscXVlciBpZGlvbWEgZSBlbSB0b2RvcyBvcyBwYcOtc2VzOwoKKDIpIEFDRUlUQSBxdWUgYSBjZXNzw6NvIHRvdGFsIG7Do28gZXhjbHVzaXZhLCBwZXJtYW5lbnRlIGUgaXJyZXZvZ8OhdmVsIGRvcyBkaXJlaXRvcyBhdXRvcmFpcwpwYXRyaW1vbmlhaXMgbsOjbyBjb21lcmNpYWlzIGRlIHV0aWxpemHDp8OjbyBkZSBxdWUgdHJhdGEgZXN0ZSBkb2N1bWVudG8gaW5jbHVpLCBleGVtcGxpZmljYXRpdmFtZW50ZSwKb3MgZGlyZWl0b3MgZGUgZGlzcG9uaWJpbGl6YcOnw6NvIGUgY29tdW5pY2HDp8OjbyBww7pibGljYSBkYSBPQlJBLCBlbSBxdWFscXVlciBtZWlvIG91IHZlw61jdWxvLAppbmNsdXNpdmUgZW0gUmVwb3NpdMOzcmlvcyBEaWdpdGFpcywgYmVtIGNvbW8gb3MgZGlyZWl0b3MgZGUgcmVwcm9kdcOnw6NvLCBleGliacOnw6NvLCBleGVjdcOnw6NvLApkZWNsYW1hw6fDo28sIHJlY2l0YcOnw6NvLCBleHBvc2nDp8OjbywgYXJxdWl2YW1lbnRvLCBpbmNsdXPDo28gZW0gYmFuY28gZGUgZGFkb3MsIHByZXNlcnZhw6fDo28sIGRpZnVzw6NvLApkaXN0cmlidWnDp8OjbywgZGl2dWxnYcOnw6NvLCBlbXByw6lzdGltbywgdHJhZHXDp8OjbywgZHVibGFnZW0sIGxlZ2VuZGFnZW0sIGluY2x1c8OjbyBlbSBub3ZhcyBvYnJhcyBvdQpjb2xldMOibmVhcywgcmV1dGlsaXphw6fDo28sIGVkacOnw6NvLCBwcm9kdcOnw6NvIGRlIG1hdGVyaWFsIGRpZMOhdGljbyBlIGN1cnNvcyBvdSBxdWFscXVlciBmb3JtYSBkZQp1dGlsaXphw6fDo28gbsOjbyBjb21lcmNpYWw7CgooMykgUkVDT05IRUNFIHF1ZSBhIGNlc3PDo28gYXF1aSBlc3BlY2lmaWNhZGEgY29uY2VkZSDDoCBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPCkNSVVogbyBkaXJlaXRvIGRlIGF1dG9yaXphciBxdWFscXVlciBwZXNzb2Eg4oCTIGbDrXNpY2Egb3UganVyw61kaWNhLCBww7pibGljYSBvdSBwcml2YWRhLCBuYWNpb25hbCBvdQplc3RyYW5nZWlyYSDigJMgYSBhY2Vzc2FyIGUgdXRpbGl6YXIgYW1wbGFtZW50ZSBhIE9CUkEsIHNlbSBleGNsdXNpdmlkYWRlLCBwYXJhIHF1YWlzcXVlcgpmaW5hbGlkYWRlcyBuw6NvIGNvbWVyY2lhaXM7CgooNCkgREVDTEFSQSBxdWUgYSBvYnJhIMOpIGNyaWHDp8OjbyBvcmlnaW5hbCBlIHF1ZSDDqSBvIHRpdHVsYXIgZG9zIGRpcmVpdG9zIGFxdWkgY2VkaWRvcyBlIGF1dG9yaXphZG9zLApyZXNwb25zYWJpbGl6YW5kby1zZSBpbnRlZ3JhbG1lbnRlIHBlbG8gY29udGXDumRvIGUgb3V0cm9zIGVsZW1lbnRvcyBxdWUgZmF6ZW0gcGFydGUgZGEgT0JSQSwKaW5jbHVzaXZlIG9zIGRpcmVpdG9zIGRlIHZveiBlIGltYWdlbSB2aW5jdWxhZG9zIMOgIE9CUkEsIG9icmlnYW5kby1zZSBhIGluZGVuaXphciB0ZXJjZWlyb3MgcG9yCmRhbm9zLCBiZW0gY29tbyBpbmRlbml6YXIgZSByZXNzYXJjaXIgYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVogZGUKZXZlbnR1YWlzIGRlc3Blc2FzIHF1ZSB2aWVyZW0gYSBzdXBvcnRhciwgZW0gcmF6w6NvIGRlIHF1YWxxdWVyIG9mZW5zYSBhIGRpcmVpdG9zIGF1dG9yYWlzIG91CmRpcmVpdG9zIGRlIHZveiBvdSBpbWFnZW0sIHByaW5jaXBhbG1lbnRlIG5vIHF1ZSBkaXogcmVzcGVpdG8gYSBwbMOhZ2lvIGUgdmlvbGHDp8O1ZXMgZGUgZGlyZWl0b3M7CgooNSkgQUZJUk1BIHF1ZSBjb25oZWNlIGEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTwpPU1dBTERPIENSVVogZSBhcyBkaXJldHJpemVzIHBhcmEgbyBmdW5jaW9uYW1lbnRvIGRvIHJlcG9zaXTDs3JpbyBpbnN0aXR1Y2lvbmFsIEFSQ0EuCgpBIFBvbMOtdGljYSBJbnN0aXR1Y2lvbmFsIGRlIEFjZXNzbyBBYmVydG8gZGEgRklPQ1JVWiAtIEZVTkRBw4fDg08gT1NXQUxETyBDUlVaIHJlc2VydmEKZXhjbHVzaXZhbWVudGUgYW8gQVVUT1Igb3MgZGlyZWl0b3MgbW9yYWlzIGUgb3MgdXNvcyBjb21lcmNpYWlzIHNvYnJlIGFzIG9icmFzIGRlIHN1YSBhdXRvcmlhCmUvb3UgdGl0dWxhcmlkYWRlLCBzZW5kbyBvcyB0ZXJjZWlyb3MgdXN1w6FyaW9zIHJlc3BvbnPDoXZlaXMgcGVsYSBhdHJpYnVpw6fDo28gZGUgYXV0b3JpYSBlIG1hbnV0ZW7Dp8OjbwpkYSBpbnRlZ3JpZGFkZSBkYSBPQlJBIGVtIHF1YWxxdWVyIHV0aWxpemHDp8Ojby4KCkEgUG9sw610aWNhIEluc3RpdHVjaW9uYWwgZGUgQWNlc3NvIEFiZXJ0byBkYSBGSU9DUlVaIC0gRlVOREHDh8ODTyBPU1dBTERPIENSVVoKcmVzcGVpdGEgb3MgY29udHJhdG9zIGUgYWNvcmRvcyBwcmVleGlzdGVudGVzIGRvcyBBdXRvcmVzIGNvbSB0ZXJjZWlyb3MsIGNhYmVuZG8gYW9zIEF1dG9yZXMKaW5mb3JtYXIgw6AgSW5zdGl0dWnDp8OjbyBhcyBjb25kacOnw7VlcyBlIG91dHJhcyByZXN0cmnDp8O1ZXMgaW1wb3N0YXMgcG9yIGVzdGVzIGluc3RydW1lbnRvcy4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Highly expressed placental miRNAs control key biological processes in human cancer cell lines
title Highly expressed placental miRNAs control key biological processes in human cancer cell lines
spellingShingle Highly expressed placental miRNAs control key biological processes in human cancer cell lines
Vidal, Daniel Onofre
Cancer
Placenta
Células tumorais
Tumorigênese
Humanos
Cancer
Placenta
Neoplastic Cells
Carcinogenesis
Humans
title_short Highly expressed placental miRNAs control key biological processes in human cancer cell lines
title_full Highly expressed placental miRNAs control key biological processes in human cancer cell lines
title_fullStr Highly expressed placental miRNAs control key biological processes in human cancer cell lines
title_full_unstemmed Highly expressed placental miRNAs control key biological processes in human cancer cell lines
title_sort Highly expressed placental miRNAs control key biological processes in human cancer cell lines
author Vidal, Daniel Onofre
author_facet Vidal, Daniel Onofre
Ramão, Anelisa
Pinheiro, Daniel Guariz
Muys, Bruna Rodrigues
Lorenzi, Julio Cesar Cetrulo
Alves, Cleidson de Pádua
Zanette, Dalila Lucíola
Molfetta, Greice Andreotti de
Duarte, Geraldo
Silva Junior, Wilson Araújo
author_role author
author2 Ramão, Anelisa
Pinheiro, Daniel Guariz
Muys, Bruna Rodrigues
Lorenzi, Julio Cesar Cetrulo
Alves, Cleidson de Pádua
Zanette, Dalila Lucíola
Molfetta, Greice Andreotti de
Duarte, Geraldo
Silva Junior, Wilson Araújo
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vidal, Daniel Onofre
Ramão, Anelisa
Pinheiro, Daniel Guariz
Muys, Bruna Rodrigues
Lorenzi, Julio Cesar Cetrulo
Alves, Cleidson de Pádua
Zanette, Dalila Lucíola
Molfetta, Greice Andreotti de
Duarte, Geraldo
Silva Junior, Wilson Araújo
dc.subject.other.pt_BR.fl_str_mv Cancer
Placenta
Células tumorais
Tumorigênese
Humanos
topic Cancer
Placenta
Células tumorais
Tumorigênese
Humanos
Cancer
Placenta
Neoplastic Cells
Carcinogenesis
Humans
dc.subject.en.pt_BR.fl_str_mv Cancer
Placenta
Neoplastic Cells
Carcinogenesis
Humans
description ZANETTE, Dalila Lucíola. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-17T17:26:51Z
dc.date.available.fl_str_mv 2018-12-17T17:26:51Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VIDAL, Daniel Onofre et al. Highly expressed placental miRNAs control key biological processes in human cancer cell lines. Oncotarget, v. 9, n. 34, p. 23554-23563, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30638
dc.identifier.issn.pt_BR.fl_str_mv 1949-2553
identifier_str_mv VIDAL, Daniel Onofre et al. Highly expressed placental miRNAs control key biological processes in human cancer cell lines. Oncotarget, v. 9, n. 34, p. 23554-23563, 2018.
1949-2553
url https://www.arca.fiocruz.br/handle/icict/30638
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/30638/1/license.txt
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