Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46119 |
Resumo: | Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. |
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Calvet, Claudia MagalhãesSilva, Tatiana AraújoThomas, DianeSuzuki, BrianHirata, KenSiqueira Neto, Jair LageMcKerrow, James H.2021-02-21T13:08:54Z2021-02-21T13:08:54Z2020CALVET, Claudia Magalhães et al. Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLOS Neglected Tropical Diseases, v. 14, n. 9, p. 1-14, Sept. 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4611910.1371/journal.pntd.0008726engPublic Library of ScienceTrypanosoma cruziDoença de ChagasPosaconazoleBenznidazoleTrypanosoma cruziChagas diseaseBenznidazolePosaconazoleLong term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazoleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCenter for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil.Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA.Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA.Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA.Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA.Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA.Chagas’ Disease, caused by the protozoan parasite Trypanosoma cruzi, is responsible for up to 41% of the heart failures in endemic areas in South America and is an emerging infection in regions of North America, Europe, and Asia. Treatment is suboptimal due to two factors. First, the lack of an adequate biomarker to predict disease severity and response to therapy; and second, up to 120-days treatment course coupled with a significant incidence of adverse effects from the drug currently used. Because the disease can manifest itself clinically a few years to decades after infection, controversy remains concerning the suitability of current drug treatment (benznidazole), and the efficacy of alternative drugs (e.g. posaconazole). We therefore followed the clinical course, and PCR detection of parasite burden, in a mouse model of infection for a full year following treatment with benznidazole or posaconazole. Efficacy of the two drugs depended on whether the treatment was performed during the acute model or the chronic model of infection. Posaconazole was clearly superior in treatment of acute disease whereas only benznidazole had efficacy in the chronic model. These results have important implications for the design and analysis of human clinical trials, and the use of specific drugs in specific clinical settings.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46119/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALClaudia_Calvet_etal_IOC_2020.pdfClaudia_Calvet_etal_IOC_2020.pdfapplication/pdf3748714https://www.arca.fiocruz.br/bitstream/icict/46119/2/Claudia_Calvet_etal_IOC_2020.pdfa14e4b7de7a1dc6eabf7e020dcbcb781MD52TEXTClaudia_Calvet_etal_IOC_2020.pdf.txtClaudia_Calvet_etal_IOC_2020.pdf.txtExtracted texttext/plain41379https://www.arca.fiocruz.br/bitstream/icict/46119/3/Claudia_Calvet_etal_IOC_2020.pdf.txteff0b9cc90efbb588bba09b0dcbfe2b8MD53icict/461192021-02-22 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| dc.title.pt_BR.fl_str_mv |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| title |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| spellingShingle |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole Calvet, Claudia Magalhães Trypanosoma cruzi Doença de Chagas Posaconazole Benznidazole Trypanosoma cruzi Chagas disease Benznidazole Posaconazole |
| title_short |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| title_full |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| title_fullStr |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| title_full_unstemmed |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| title_sort |
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole |
| author |
Calvet, Claudia Magalhães |
| author_facet |
Calvet, Claudia Magalhães Silva, Tatiana Araújo Thomas, Diane Suzuki, Brian Hirata, Ken Siqueira Neto, Jair Lage McKerrow, James H. |
| author_role |
author |
| author2 |
Silva, Tatiana Araújo Thomas, Diane Suzuki, Brian Hirata, Ken Siqueira Neto, Jair Lage McKerrow, James H. |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Calvet, Claudia Magalhães Silva, Tatiana Araújo Thomas, Diane Suzuki, Brian Hirata, Ken Siqueira Neto, Jair Lage McKerrow, James H. |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas Posaconazole Benznidazole |
| topic |
Trypanosoma cruzi Doença de Chagas Posaconazole Benznidazole Trypanosoma cruzi Chagas disease Benznidazole Posaconazole |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas disease Benznidazole Posaconazole |
| description |
Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California. San Diego, California, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020 |
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2021-02-21T13:08:54Z |
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2021-02-21T13:08:54Z |
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info:eu-repo/semantics/article |
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CALVET, Claudia Magalhães et al. Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLOS Neglected Tropical Diseases, v. 14, n. 9, p. 1-14, Sept. 2020. |
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https://www.arca.fiocruz.br/handle/icict/46119 |
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1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0008726 |
| identifier_str_mv |
CALVET, Claudia Magalhães et al. Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole. PLOS Neglected Tropical Diseases, v. 14, n. 9, p. 1-14, Sept. 2020. 1935-2727 10.1371/journal.pntd.0008726 |
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