The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study

Detalhes bibliográficos
Autor(a) principal: Do, Ron
Data de Publicação: 2011
Outros Autores: Xie, Changchun, Zhang, Xiaohe, Männistö, Satu, Harald, Kennet, Islam, Shofiqul, Bailey, Swneke D., Rangarajan, Sumathy, McQueen, Matthew J., Diaz, Rafael, Lisheng, Liu, Wang, Xingyu, Silander, Kaisa, Peltonen, Leena, Yusuf, Salim, Salomaa, Veikko, Engert, James C., Anand, Sonia S. A., INTERHEART investigators
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36676
Resumo: Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. INTERHEART national coordinators* and investigators Argentina: R Diaz*, E Paolasso*, M Ciruzzi*, Instituto Cardiovascular de Rosario R Nordaby, CH Sosa, HL Luciardi, EM Marzetti, JA Piasentin, M Muchastegui, C Cuneo, G Zapata, JO Bono, EM Marxetti, A Caccavo, RAA Guerrero, R Nordaby, C Dizeo; Australia and New Zealand: D Hunt*, J Varigos*, University of Melbourne, Royal Melbourne Hospital M Sallaberger, G Aroney, P Hicks, D Campbell, J Amerena, W Walsh, G Nelson, D Careless, J Durech, K Gunawardane, A Thomson, D Owensby, A Buncle, B Watson, H Ikram, M Audeau, M Hills, D Rosen, J Rankin, A Tunesi, J Sampson, K Roberts, A Hamer, L Roberts, B Singh, C Singh, R Hendriks, G Tulloch, A Hill, D Rees, C Hall; Bahrain: MA Halim*, Al Khalifa, Cardiac Centre MI Amin; Bangladesh: S Haque*, Sheik Mujih, Medical University/Institute of Post Grad Medicine GM Faruque, M Hossain; Benin Republic: H Agboton*, General Teaching Hospital/Medical School; Botswana: C Onen*, Center for Chronic Diseases, Gaborone Private Hospital, Gaborone; Brazil: A Avezum*, L Piegas*, Instituto Dante Pazzanese de Cardiologia, Sao Paulo G Reis, JP Esteves, LC Bodanese, AR Junior, JAM Neto, RF Ramos, ES Silva, A Labrunie, ACC Carvalho, IP Filho, DCD Albuquerque, JAM Abrantes, OCE Gebara, PE Leaes, SS Xavier, RL Marino, O Dutra; Cameroon: W Muna*, K N Blackett*, CHU, Yaoundé; Canada: K Teo*, S Yusuf*, Hamilton General Hospital, Hamilton S Ounpuu, YK Chan, C Joyner, AD Kitching, A Morris, A Panju, H Lee, I Bata, B May, JG Hiscock, PV Greenwood, W Tymchak, M Natarajan; Chile: F Lanas*, Facultad de Medicina, Universidad de la Frontera, Temuco D Standen, A Lanas, C Santibanez, P Soto, S Potthoff, R Soto, E Mercadal; China: L S Liu*, L X Jiang*, Beijing Hypertension League Institute and Fu Wai Hospital, Beijing Q Chen, N Sun, J Wang, L Zhang, X Li, H Chen, Z Li, Y Shi, J Meng, D Wang, Z Liu, J Yan, W Zhang, Z Wan, Y Xu, X Li, L Wang, Q Fu, K Zhu, Y Wang, X Wang, F Wang, R Liu, R Zhao, K Sun, S Yue, Y Zhang, X Zhao, L Zhao, C Zhou, X Meng, A Liu, X Li, R Wu, R Xiao, X Zhang, G Wan, X Chen, Z Ge, T Zhou, Y Li, X Zhou, F Zhang; Colombia: LE Bautista*, Fundación Cardiovascular del Oriente Colombiano JP Casas, CA Morillo, E Ardilla, IA Arenas, M Lindarte, D Aristizabal; Croatia: Z Rumboldt*, University of Split M Rumboldt, V Carevic; Czech Republic: P Widimsky*, Charles University, Prague M Branny, P Gregor; Egypt: MS Khedr*, Suez Canal University, Cario MG Abdel-Aziz, S Abdel-Kader, MA Abdel-Moneim, F El-Demerdash, A El-Saiid, S Gharib, M Hassanin, F Abdel-Hamid Maklady, I Sadek; Germany: HJ Rupprecht*, T Wittlinger*, Oberarzt der II Medizinische Klinik P Schuster, A Schmidt, HR Ochs; Greece: N Karatzas*, A Pipilis*, Athens Hygeria SA D Symeonides, K Karidis, TH Tsaknakis, K Kyfnidis; Guatemala: M Luna*, Unidad de Cirugia Cardiovascular de Guatemala AM Arroyo, G Sotomora, MA Rodas, L Velasquez, A Ovando; Hong Kong: J Sanderson*, Chinese University of Hong Kong, Prince of Wales Hospital WY Ma, S Chan; Hungary: M Keltai*, Hungary Institute of Cardiology Budapest F Szaboki, P Karpati, K Toth, S Timar, E Kalo, A Janosi, M Rusznak, D Lehoczky, J Tarjan, E Kiss, E Sitkei, P Valyi, I Edes; India: P Pais*, KS Reddy*, St. John’s Medical College and All India Institute of Medical Sciences PP Joshi, D Prabhakaran, D Xavier, A Roy, L Ramakrishnan; Iran: MRM Hasani*, SH Mirkhani*, Islamic Azad University, Tehran; Israel: D Halon*, B Lewis*, Lady Davis Carmel Hospital, Haifa; Italy: MG Franzosi*, G Tognoni*, Department of Cardiovascular Research, Instituto Mario Negri, Milano E Gardinale, M Villella, M Mennuni, F Saiu, G Pettinati, S Ciricugno, S Antonaci, L Carrieri, E Balli, D Bicego, MG DelleDonne, A Ottaviano, L Moretti, C Melloni, G Melandri, E Carbonieri, A Vetrano; Japan: M Hori*, Osaka University Graduate School of Medicine, Suita H Sato, K Fujii; Kenya: EN Ogola*, Nairobi Hospital P Wangai; Kuwait: M Zubaid*, Kuwait University, Kuwait City W Rashed; Malaysia: CC Lang*, University Malaya, Faculty of Medicine, Kuala Lumpur WAW Ahmad, A Kadirvelu, R Zambahari; Mexico: MA Ramos-Corrales*, Hospital de Especialidades, Mexico City; Mozambique: A Damasceno*, Maputo General Hospital; Nepal: M R Pandey*, Nepal Heart Foundation G Baniya, A Sayami, M Kiratee, B Rawat, M Pandey, J Gurung; Netherlands: R Peters*, Acadmisch Medisch Centrum DCG Basart, PNA Bronzwaer, JA Heijmeriks, HR Michels, GMA Pop; Nigeria: KK Akinroye*, Nigerian Heart Foundation; Pakistan: K Kazmi*, The Aga Khan University, Karachi NA Memon, SK Memon, S Nishtar, A Badar, MA Mattu, M Yakub, K Soomra, J Khatri, AMA Faruqui, SI Rasool, A Samad; Philippines: AL Dans*, Philippines General Hospital FQ Punzalan, MVC Villarruz, BT Mendoza, CS Recto III, BR Tamesis, V Mendoza, DJ Torres, DD Morales, I Ongtengco; Poland: A Budaj*, L Ceremuzynski*, Grochowski Hospital, Klinika Kardiologii CMKP, Warsawa S Stec, J Gorny, K Prochniewska, TK Urbanek, P Wojewoda, M Pawlowski, K Religa, R Klabisz, H Latocha, M Szpajer, K Cymerman, M Laniec, H Danielewicz, M Ogorek, D Kopcik, A Baranowska, A Kozlowski, M Blachowicz, A Jedrzejowski, T Waszyrowski, Z Zielinski, K Janik, M Tomzynski, M Mytnik, A Maziarz, G Rembelska, M Piepiorka, K Debkowska, T Krynski, B S Szczeklik, W Krasowski, M Rozwodowska, P Miekus, J Surwilo, S Malinowski, J Hybel, M Michalak, P Achremczyk, J Majchrzak, W S Korombel, M Dobrowolski, J Gessek; Portugal: J Morais*, University Hospital, Coronary Care Unit; Qatar: AA Gehani*, HA Hajar*, Hamad General Hospital MM Almowla, AA Omer; Russia: EG Volkova*, Ural State Medical Academy, Chelyabinsk SU Levashov, OM Filatova, UI Evchenko, GS Malkiman, NN Karaulovskaya; Seychelles: J Panovsky*, Victoria Hospital; Singapore: BA Johan*, National Heart Centre A Cheng, KS Ng, YL Lim, KH Neoh, KS Tan, LN Lum, Y Cheah; South Africa: P Commerford*, K Steyn*, University of Cape Town B Brown, F Martiz, P Raubenheimer, A Aboo, JD Marx, E Batiste, K Sliwa, P Sareli, C Zambiakides; Spain: V Valentin*, Universitari Dr Peset, Valencia J Ferriz, A Rovira, A Rodriguez-Llorian, E Cereijo, T Monzo, N Alonso, E Gomez-Martinez, A Lopez-Perez; Sri Lanka: S Mendis*, Peradeniya Teaching Hospital T Jayalath; Sultanate of Oman: ATA Hinai*, Sultan Qaboos University, Muscat MO Hassan; Sweden: A Rosengren*, Sahlgrenska University Hospital/Ostra, Göteborg; Thailand: C Sitthi-Amorn*, Department of Medicine, Chulalongkorn University, Bangkok S Chaithiraphan, K Bhuripanyo, S Srimahachota, M Anukulwutipong, P Loothavorn, P Sritara, S Tanomsup, J Tantitham, P Tatsanavivat, T Yipinsoi, W Jintapakorn, W Puavilai, B Koanantakul, P Kasemsuwan, C Supanantareauk, C Peamsomboon, B Saejueng, K Jeamsomboon, A Sukontasup; United Arab Emirates: W Almahmeed*, Al-Jazeira and Central Hospitals, Abu Dhabi LO Abdelwareth, A Bokhari, NS Rao, S Bakir, AM Yusufali, E Hatou, Q Zaidi; UK: K Fox*, M Flather*, Royal Infirmary of Edinburgh, Edinburgh; USA: J Probstfield*, University of Washington, Seattle R Freeman, J Mathew, M Schweiger, W Johnson, E Ofili; Zimbabwe: J Chifamba*, University of Zimbabwe AJG Hakim.
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spelling Do, RonXie, ChangchunZhang, XiaoheMännistö, SatuHarald, KennetIslam, ShofiqulBailey, Swneke D.Rangarajan, SumathyMcQueen, Matthew J.Diaz, RafaelLisheng, LiuWang, XingyuSilander, KaisaPeltonen, LeenaYusuf, SalimSalomaa, VeikkoEngert, James C.Anand, Sonia S. A.INTERHEART investigators2019-10-23T14:13:52Z2019-10-23T14:13:52Z2011DO, Ron et al. The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. Plos Medicine, v. 8, n. 10, p. 1-10, 2011.1549-1277https://www.arca.fiocruz.br/handle/icict/3667610.1371/journal.pmed.10011061549-1676Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. INTERHEART national coordinators* and investigators Argentina: R Diaz*, E Paolasso*, M Ciruzzi*, Instituto Cardiovascular de Rosario R Nordaby, CH Sosa, HL Luciardi, EM Marzetti, JA Piasentin, M Muchastegui, C Cuneo, G Zapata, JO Bono, EM Marxetti, A Caccavo, RAA Guerrero, R Nordaby, C Dizeo; Australia and New Zealand: D Hunt*, J Varigos*, University of Melbourne, Royal Melbourne Hospital M Sallaberger, G Aroney, P Hicks, D Campbell, J Amerena, W Walsh, G Nelson, D Careless, J Durech, K Gunawardane, A Thomson, D Owensby, A Buncle, B Watson, H Ikram, M Audeau, M Hills, D Rosen, J Rankin, A Tunesi, J Sampson, K Roberts, A Hamer, L Roberts, B Singh, C Singh, R Hendriks, G Tulloch, A Hill, D Rees, C Hall; Bahrain: MA Halim*, Al Khalifa, Cardiac Centre MI Amin; Bangladesh: S Haque*, Sheik Mujih, Medical University/Institute of Post Grad Medicine GM Faruque, M Hossain; Benin Republic: H Agboton*, General Teaching Hospital/Medical School; Botswana: C Onen*, Center for Chronic Diseases, Gaborone Private Hospital, Gaborone; Brazil: A Avezum*, L Piegas*, Instituto Dante Pazzanese de Cardiologia, Sao Paulo G Reis, JP Esteves, LC Bodanese, AR Junior, JAM Neto, RF Ramos, ES Silva, A Labrunie, ACC Carvalho, IP Filho, DCD Albuquerque, JAM Abrantes, OCE Gebara, PE Leaes, SS Xavier, RL Marino, O Dutra; Cameroon: W Muna*, K N Blackett*, CHU, Yaoundé; Canada: K Teo*, S Yusuf*, Hamilton General Hospital, Hamilton S Ounpuu, YK Chan, C Joyner, AD Kitching, A Morris, A Panju, H Lee, I Bata, B May, JG Hiscock, PV Greenwood, W Tymchak, M Natarajan; Chile: F Lanas*, Facultad de Medicina, Universidad de la Frontera, Temuco D Standen, A Lanas, C Santibanez, P Soto, S Potthoff, R Soto, E Mercadal; China: L S Liu*, L X Jiang*, Beijing Hypertension League Institute and Fu Wai Hospital, Beijing Q Chen, N Sun, J Wang, L Zhang, X Li, H Chen, Z Li, Y Shi, J Meng, D Wang, Z Liu, J Yan, W Zhang, Z Wan, Y Xu, X Li, L Wang, Q Fu, K Zhu, Y Wang, X Wang, F Wang, R Liu, R Zhao, K Sun, S Yue, Y Zhang, X Zhao, L Zhao, C Zhou, X Meng, A Liu, X Li, R Wu, R Xiao, X Zhang, G Wan, X Chen, Z Ge, T Zhou, Y Li, X Zhou, F Zhang; Colombia: LE Bautista*, Fundación Cardiovascular del Oriente Colombiano JP Casas, CA Morillo, E Ardilla, IA Arenas, M Lindarte, D Aristizabal; Croatia: Z Rumboldt*, University of Split M Rumboldt, V Carevic; Czech Republic: P Widimsky*, Charles University, Prague M Branny, P Gregor; Egypt: MS Khedr*, Suez Canal University, Cario MG Abdel-Aziz, S Abdel-Kader, MA Abdel-Moneim, F El-Demerdash, A El-Saiid, S Gharib, M Hassanin, F Abdel-Hamid Maklady, I Sadek; Germany: HJ Rupprecht*, T Wittlinger*, Oberarzt der II Medizinische Klinik P Schuster, A Schmidt, HR Ochs; Greece: N Karatzas*, A Pipilis*, Athens Hygeria SA D Symeonides, K Karidis, TH Tsaknakis, K Kyfnidis; Guatemala: M Luna*, Unidad de Cirugia Cardiovascular de Guatemala AM Arroyo, G Sotomora, MA Rodas, L Velasquez, A Ovando; Hong Kong: J Sanderson*, Chinese University of Hong Kong, Prince of Wales Hospital WY Ma, S Chan; Hungary: M Keltai*, Hungary Institute of Cardiology Budapest F Szaboki, P Karpati, K Toth, S Timar, E Kalo, A Janosi, M Rusznak, D Lehoczky, J Tarjan, E Kiss, E Sitkei, P Valyi, I Edes; India: P Pais*, KS Reddy*, St. John’s Medical College and All India Institute of Medical Sciences PP Joshi, D Prabhakaran, D Xavier, A Roy, L Ramakrishnan; Iran: MRM Hasani*, SH Mirkhani*, Islamic Azad University, Tehran; Israel: D Halon*, B Lewis*, Lady Davis Carmel Hospital, Haifa; Italy: MG Franzosi*, G Tognoni*, Department of Cardiovascular Research, Instituto Mario Negri, Milano E Gardinale, M Villella, M Mennuni, F Saiu, G Pettinati, S Ciricugno, S Antonaci, L Carrieri, E Balli, D Bicego, MG DelleDonne, A Ottaviano, L Moretti, C Melloni, G Melandri, E Carbonieri, A Vetrano; Japan: M Hori*, Osaka University Graduate School of Medicine, Suita H Sato, K Fujii; Kenya: EN Ogola*, Nairobi Hospital P Wangai; Kuwait: M Zubaid*, Kuwait University, Kuwait City W Rashed; Malaysia: CC Lang*, University Malaya, Faculty of Medicine, Kuala Lumpur WAW Ahmad, A Kadirvelu, R Zambahari; Mexico: MA Ramos-Corrales*, Hospital de Especialidades, Mexico City; Mozambique: A Damasceno*, Maputo General Hospital; Nepal: M R Pandey*, Nepal Heart Foundation G Baniya, A Sayami, M Kiratee, B Rawat, M Pandey, J Gurung; Netherlands: R Peters*, Acadmisch Medisch Centrum DCG Basart, PNA Bronzwaer, JA Heijmeriks, HR Michels, GMA Pop; Nigeria: KK Akinroye*, Nigerian Heart Foundation; Pakistan: K Kazmi*, The Aga Khan University, Karachi NA Memon, SK Memon, S Nishtar, A Badar, MA Mattu, M Yakub, K Soomra, J Khatri, AMA Faruqui, SI Rasool, A Samad; Philippines: AL Dans*, Philippines General Hospital FQ Punzalan, MVC Villarruz, BT Mendoza, CS Recto III, BR Tamesis, V Mendoza, DJ Torres, DD Morales, I Ongtengco; Poland: A Budaj*, L Ceremuzynski*, Grochowski Hospital, Klinika Kardiologii CMKP, Warsawa S Stec, J Gorny, K Prochniewska, TK Urbanek, P Wojewoda, M Pawlowski, K Religa, R Klabisz, H Latocha, M Szpajer, K Cymerman, M Laniec, H Danielewicz, M Ogorek, D Kopcik, A Baranowska, A Kozlowski, M Blachowicz, A Jedrzejowski, T Waszyrowski, Z Zielinski, K Janik, M Tomzynski, M Mytnik, A Maziarz, G Rembelska, M Piepiorka, K Debkowska, T Krynski, B S Szczeklik, W Krasowski, M Rozwodowska, P Miekus, J Surwilo, S Malinowski, J Hybel, M Michalak, P Achremczyk, J Majchrzak, W S Korombel, M Dobrowolski, J Gessek; Portugal: J Morais*, University Hospital, Coronary Care Unit; Qatar: AA Gehani*, HA Hajar*, Hamad General Hospital MM Almowla, AA Omer; Russia: EG Volkova*, Ural State Medical Academy, Chelyabinsk SU Levashov, OM Filatova, UI Evchenko, GS Malkiman, NN Karaulovskaya; Seychelles: J Panovsky*, Victoria Hospital; Singapore: BA Johan*, National Heart Centre A Cheng, KS Ng, YL Lim, KH Neoh, KS Tan, LN Lum, Y Cheah; South Africa: P Commerford*, K Steyn*, University of Cape Town B Brown, F Martiz, P Raubenheimer, A Aboo, JD Marx, E Batiste, K Sliwa, P Sareli, C Zambiakides; Spain: V Valentin*, Universitari Dr Peset, Valencia J Ferriz, A Rovira, A Rodriguez-Llorian, E Cereijo, T Monzo, N Alonso, E Gomez-Martinez, A Lopez-Perez; Sri Lanka: S Mendis*, Peradeniya Teaching Hospital T Jayalath; Sultanate of Oman: ATA Hinai*, Sultan Qaboos University, Muscat MO Hassan; Sweden: A Rosengren*, Sahlgrenska University Hospital/Ostra, Göteborg; Thailand: C Sitthi-Amorn*, Department of Medicine, Chulalongkorn University, Bangkok S Chaithiraphan, K Bhuripanyo, S Srimahachota, M Anukulwutipong, P Loothavorn, P Sritara, S Tanomsup, J Tantitham, P Tatsanavivat, T Yipinsoi, W Jintapakorn, W Puavilai, B Koanantakul, P Kasemsuwan, C Supanantareauk, C Peamsomboon, B Saejueng, K Jeamsomboon, A Sukontasup; United Arab Emirates: W Almahmeed*, Al-Jazeira and Central Hospitals, Abu Dhabi LO Abdelwareth, A Bokhari, NS Rao, S Bakir, AM Yusufali, E Hatou, Q Zaidi; UK: K Fox*, M Flather*, Royal Infirmary of Edinburgh, Edinburgh; USA: J Probstfield*, University of Washington, Seattle R Freeman, J Mathew, M Schweiger, W Johnson, E Ofili; Zimbabwe: J Chifamba*, University of Zimbabwe AJG Hakim.McGill University. Department of Human Genetics. Montréal, QC, Canada.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada / McMaster University. Departments of Medicine and Clinical Epidemiology and Biostatistics. Hamilton, ON, Canada.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada.National Institute for Health and Welfare. Department of Chronic Disease Prevention. Helsinki, Finland.National Institute for Health and Welfare. Department of Chronic Disease Prevention. Helsinki, Finland.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada / McMaster University. Departments of Medicine and Clinical Epidemiology and Biostatistics. Hamilton, ON, Canada.McGill University. Department of Human Genetics. Montréal, QC, Canada.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada.Estudios Cardiologicos Latinoamerica. Rosario, Argentina.Chinese Hypertension League Institute. Cardiovascular Institute and Fu Wai Hospital. Beijing, China.Beijing Hypertension League Institute. Laboratory of Human Genetics. Beijing, China.National Institute for Health and Welfare. Department of Chronic Disease Prevention. Helsinki, Finland / University of Helsinki. Institute for Molecular Medicine Finland. Human Genomics Unit. Helsinki, Finland.National Institute for Health and Welfare. Department of Chronic Disease Prevention. Helsinki, Finland / University of Helsinki. Institute for Molecular Medicine Finland. Human Genomics Unit. Helsinki, Finland.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada.National Institute for Health and Welfare. Department of Chronic Disease Prevention. Helsinki, Finland.McGill University. Department of Human Genetics. Montréal, QC, Canada / McGill University. Department of Medicine. Montréal, QC, Canada / McGill University Health Centre. Research Institute. Montréal, QC, Canada.Population Health Research Institute. Hamilton, ON, Canada / Hamilton Health Sciences. Hamilton, ON, Canada / McMaster University. Hamilton, ON, Canada / McMaster University. Departments of Medicine and Clinical Epidemiology and Biostatistics. Hamilton, ON, Canada.Background: One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. Methods and Findings: We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.8561028#p#5.2161027). A significant interaction (p = 4.061024 ) was observed between rs2383206 and a factor-analysis-derived ‘‘prudent’’ diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.8261027 ), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.961023 ) and high prudent diet scoring groups (OR = 1.02, p = 0.68) (p = 0.014 for difference). We also analyzed data from 19,129 individuals (including 1,014 incident cases of CVD) from the prospective FINRISK study, which used a closely related dietary variable. In this analysis, the 9p21 risk allele demonstrated a larger effect on CVD risk in the groups with diets low or average for fresh vegetables, fruits, and berries (hazard ratio [HR] = 1.22, p = 3.061024, and HR = 1.35, p = 4.161023, respectively) compared to the group with high consumption of these foods (HR = 0.96, p = 0.73) (p = 0.0011 for difference). The combination of the least prudent diet and two copies of the risk allele was associated with a 2-fold increase in risk for MI (OR = 1.98, p = 2.1161029 ) in the INTERHEART study and a 1.66-fold increase in risk for CVD in the FINRISK study (HR = 1.66, p = 0.0026). Conclusions: The risk of MI and CVD conferred by Chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits.engPublic Library of ScienceThe effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCardiovascular diseaseChromosome 9p21Dietary intakeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36676/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Do_Ron_etal_INI_2011.pdfve_Do_Ron_etal_INI_2011.pdfapplication/pdf598090https://www.arca.fiocruz.br/bitstream/icict/36676/2/ve_Do_Ron_etal_INI_2011.pdf41a9960301aee2fdf5acd6c6ffc6fb13MD52journal.pmed.1001106.s004.DOCjournal.pmed.1001106.s004.DOCapplication/msword45056https://www.arca.fiocruz.br/bitstream/icict/36676/4/journal.pmed.1001106.s004.DOCfc6fb63f66d0d680ff6b44d8234d7af5MD54TEXTve_Do_Ron_etal_INI_2011.pdf.txtve_Do_Ron_etal_INI_2011.pdf.txtExtracted texttext/plain49930https://www.arca.fiocruz.br/bitstream/icict/36676/3/ve_Do_Ron_etal_INI_2011.pdf.txte01aaf0786dd70535efde4b1bd9f6205MD53journal.pmed.1001106.s004.DOC.txtjournal.pmed.1001106.s004.DOC.txtExtracted texttext/plain7278https://www.arca.fiocruz.br/bitstream/icict/36676/5/journal.pmed.1001106.s004.DOC.txt82b1d5238f3fcf36ed3f66d39701fecfMD55icict/366762019-10-26 02:00:34.493oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-26T05:00:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
title The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
spellingShingle The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
Do, Ron
Cardiovascular disease
Chromosome 9p21
Dietary intake
title_short The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
title_full The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
title_fullStr The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
title_full_unstemmed The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
title_sort The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study
author Do, Ron
author_facet Do, Ron
Xie, Changchun
Zhang, Xiaohe
Männistö, Satu
Harald, Kennet
Islam, Shofiqul
Bailey, Swneke D.
Rangarajan, Sumathy
McQueen, Matthew J.
Diaz, Rafael
Lisheng, Liu
Wang, Xingyu
Silander, Kaisa
Peltonen, Leena
Yusuf, Salim
Salomaa, Veikko
Engert, James C.
Anand, Sonia S. A.
INTERHEART investigators
author_role author
author2 Xie, Changchun
Zhang, Xiaohe
Männistö, Satu
Harald, Kennet
Islam, Shofiqul
Bailey, Swneke D.
Rangarajan, Sumathy
McQueen, Matthew J.
Diaz, Rafael
Lisheng, Liu
Wang, Xingyu
Silander, Kaisa
Peltonen, Leena
Yusuf, Salim
Salomaa, Veikko
Engert, James C.
Anand, Sonia S. A.
INTERHEART investigators
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Do, Ron
Xie, Changchun
Zhang, Xiaohe
Männistö, Satu
Harald, Kennet
Islam, Shofiqul
Bailey, Swneke D.
Rangarajan, Sumathy
McQueen, Matthew J.
Diaz, Rafael
Lisheng, Liu
Wang, Xingyu
Silander, Kaisa
Peltonen, Leena
Yusuf, Salim
Salomaa, Veikko
Engert, James C.
Anand, Sonia S. A.
INTERHEART investigators
dc.subject.en.pt_BR.fl_str_mv Cardiovascular disease
Chromosome 9p21
Dietary intake
topic Cardiovascular disease
Chromosome 9p21
Dietary intake
description Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. INTERHEART national coordinators* and investigators Argentina: R Diaz*, E Paolasso*, M Ciruzzi*, Instituto Cardiovascular de Rosario R Nordaby, CH Sosa, HL Luciardi, EM Marzetti, JA Piasentin, M Muchastegui, C Cuneo, G Zapata, JO Bono, EM Marxetti, A Caccavo, RAA Guerrero, R Nordaby, C Dizeo; Australia and New Zealand: D Hunt*, J Varigos*, University of Melbourne, Royal Melbourne Hospital M Sallaberger, G Aroney, P Hicks, D Campbell, J Amerena, W Walsh, G Nelson, D Careless, J Durech, K Gunawardane, A Thomson, D Owensby, A Buncle, B Watson, H Ikram, M Audeau, M Hills, D Rosen, J Rankin, A Tunesi, J Sampson, K Roberts, A Hamer, L Roberts, B Singh, C Singh, R Hendriks, G Tulloch, A Hill, D Rees, C Hall; Bahrain: MA Halim*, Al Khalifa, Cardiac Centre MI Amin; Bangladesh: S Haque*, Sheik Mujih, Medical University/Institute of Post Grad Medicine GM Faruque, M Hossain; Benin Republic: H Agboton*, General Teaching Hospital/Medical School; Botswana: C Onen*, Center for Chronic Diseases, Gaborone Private Hospital, Gaborone; Brazil: A Avezum*, L Piegas*, Instituto Dante Pazzanese de Cardiologia, Sao Paulo G Reis, JP Esteves, LC Bodanese, AR Junior, JAM Neto, RF Ramos, ES Silva, A Labrunie, ACC Carvalho, IP Filho, DCD Albuquerque, JAM Abrantes, OCE Gebara, PE Leaes, SS Xavier, RL Marino, O Dutra; Cameroon: W Muna*, K N Blackett*, CHU, Yaoundé; Canada: K Teo*, S Yusuf*, Hamilton General Hospital, Hamilton S Ounpuu, YK Chan, C Joyner, AD Kitching, A Morris, A Panju, H Lee, I Bata, B May, JG Hiscock, PV Greenwood, W Tymchak, M Natarajan; Chile: F Lanas*, Facultad de Medicina, Universidad de la Frontera, Temuco D Standen, A Lanas, C Santibanez, P Soto, S Potthoff, R Soto, E Mercadal; China: L S Liu*, L X Jiang*, Beijing Hypertension League Institute and Fu Wai Hospital, Beijing Q Chen, N Sun, J Wang, L Zhang, X Li, H Chen, Z Li, Y Shi, J Meng, D Wang, Z Liu, J Yan, W Zhang, Z Wan, Y Xu, X Li, L Wang, Q Fu, K Zhu, Y Wang, X Wang, F Wang, R Liu, R Zhao, K Sun, S Yue, Y Zhang, X Zhao, L Zhao, C Zhou, X Meng, A Liu, X Li, R Wu, R Xiao, X Zhang, G Wan, X Chen, Z Ge, T Zhou, Y Li, X Zhou, F Zhang; Colombia: LE Bautista*, Fundación Cardiovascular del Oriente Colombiano JP Casas, CA Morillo, E Ardilla, IA Arenas, M Lindarte, D Aristizabal; Croatia: Z Rumboldt*, University of Split M Rumboldt, V Carevic; Czech Republic: P Widimsky*, Charles University, Prague M Branny, P Gregor; Egypt: MS Khedr*, Suez Canal University, Cario MG Abdel-Aziz, S Abdel-Kader, MA Abdel-Moneim, F El-Demerdash, A El-Saiid, S Gharib, M Hassanin, F Abdel-Hamid Maklady, I Sadek; Germany: HJ Rupprecht*, T Wittlinger*, Oberarzt der II Medizinische Klinik P Schuster, A Schmidt, HR Ochs; Greece: N Karatzas*, A Pipilis*, Athens Hygeria SA D Symeonides, K Karidis, TH Tsaknakis, K Kyfnidis; Guatemala: M Luna*, Unidad de Cirugia Cardiovascular de Guatemala AM Arroyo, G Sotomora, MA Rodas, L Velasquez, A Ovando; Hong Kong: J Sanderson*, Chinese University of Hong Kong, Prince of Wales Hospital WY Ma, S Chan; Hungary: M Keltai*, Hungary Institute of Cardiology Budapest F Szaboki, P Karpati, K Toth, S Timar, E Kalo, A Janosi, M Rusznak, D Lehoczky, J Tarjan, E Kiss, E Sitkei, P Valyi, I Edes; India: P Pais*, KS Reddy*, St. John’s Medical College and All India Institute of Medical Sciences PP Joshi, D Prabhakaran, D Xavier, A Roy, L Ramakrishnan; Iran: MRM Hasani*, SH Mirkhani*, Islamic Azad University, Tehran; Israel: D Halon*, B Lewis*, Lady Davis Carmel Hospital, Haifa; Italy: MG Franzosi*, G Tognoni*, Department of Cardiovascular Research, Instituto Mario Negri, Milano E Gardinale, M Villella, M Mennuni, F Saiu, G Pettinati, S Ciricugno, S Antonaci, L Carrieri, E Balli, D Bicego, MG DelleDonne, A Ottaviano, L Moretti, C Melloni, G Melandri, E Carbonieri, A Vetrano; Japan: M Hori*, Osaka University Graduate School of Medicine, Suita H Sato, K Fujii; Kenya: EN Ogola*, Nairobi Hospital P Wangai; Kuwait: M Zubaid*, Kuwait University, Kuwait City W Rashed; Malaysia: CC Lang*, University Malaya, Faculty of Medicine, Kuala Lumpur WAW Ahmad, A Kadirvelu, R Zambahari; Mexico: MA Ramos-Corrales*, Hospital de Especialidades, Mexico City; Mozambique: A Damasceno*, Maputo General Hospital; Nepal: M R Pandey*, Nepal Heart Foundation G Baniya, A Sayami, M Kiratee, B Rawat, M Pandey, J Gurung; Netherlands: R Peters*, Acadmisch Medisch Centrum DCG Basart, PNA Bronzwaer, JA Heijmeriks, HR Michels, GMA Pop; Nigeria: KK Akinroye*, Nigerian Heart Foundation; Pakistan: K Kazmi*, The Aga Khan University, Karachi NA Memon, SK Memon, S Nishtar, A Badar, MA Mattu, M Yakub, K Soomra, J Khatri, AMA Faruqui, SI Rasool, A Samad; Philippines: AL Dans*, Philippines General Hospital FQ Punzalan, MVC Villarruz, BT Mendoza, CS Recto III, BR Tamesis, V Mendoza, DJ Torres, DD Morales, I Ongtengco; Poland: A Budaj*, L Ceremuzynski*, Grochowski Hospital, Klinika Kardiologii CMKP, Warsawa S Stec, J Gorny, K Prochniewska, TK Urbanek, P Wojewoda, M Pawlowski, K Religa, R Klabisz, H Latocha, M Szpajer, K Cymerman, M Laniec, H Danielewicz, M Ogorek, D Kopcik, A Baranowska, A Kozlowski, M Blachowicz, A Jedrzejowski, T Waszyrowski, Z Zielinski, K Janik, M Tomzynski, M Mytnik, A Maziarz, G Rembelska, M Piepiorka, K Debkowska, T Krynski, B S Szczeklik, W Krasowski, M Rozwodowska, P Miekus, J Surwilo, S Malinowski, J Hybel, M Michalak, P Achremczyk, J Majchrzak, W S Korombel, M Dobrowolski, J Gessek; Portugal: J Morais*, University Hospital, Coronary Care Unit; Qatar: AA Gehani*, HA Hajar*, Hamad General Hospital MM Almowla, AA Omer; Russia: EG Volkova*, Ural State Medical Academy, Chelyabinsk SU Levashov, OM Filatova, UI Evchenko, GS Malkiman, NN Karaulovskaya; Seychelles: J Panovsky*, Victoria Hospital; Singapore: BA Johan*, National Heart Centre A Cheng, KS Ng, YL Lim, KH Neoh, KS Tan, LN Lum, Y Cheah; South Africa: P Commerford*, K Steyn*, University of Cape Town B Brown, F Martiz, P Raubenheimer, A Aboo, JD Marx, E Batiste, K Sliwa, P Sareli, C Zambiakides; Spain: V Valentin*, Universitari Dr Peset, Valencia J Ferriz, A Rovira, A Rodriguez-Llorian, E Cereijo, T Monzo, N Alonso, E Gomez-Martinez, A Lopez-Perez; Sri Lanka: S Mendis*, Peradeniya Teaching Hospital T Jayalath; Sultanate of Oman: ATA Hinai*, Sultan Qaboos University, Muscat MO Hassan; Sweden: A Rosengren*, Sahlgrenska University Hospital/Ostra, Göteborg; Thailand: C Sitthi-Amorn*, Department of Medicine, Chulalongkorn University, Bangkok S Chaithiraphan, K Bhuripanyo, S Srimahachota, M Anukulwutipong, P Loothavorn, P Sritara, S Tanomsup, J Tantitham, P Tatsanavivat, T Yipinsoi, W Jintapakorn, W Puavilai, B Koanantakul, P Kasemsuwan, C Supanantareauk, C Peamsomboon, B Saejueng, K Jeamsomboon, A Sukontasup; United Arab Emirates: W Almahmeed*, Al-Jazeira and Central Hospitals, Abu Dhabi LO Abdelwareth, A Bokhari, NS Rao, S Bakir, AM Yusufali, E Hatou, Q Zaidi; UK: K Fox*, M Flather*, Royal Infirmary of Edinburgh, Edinburgh; USA: J Probstfield*, University of Washington, Seattle R Freeman, J Mathew, M Schweiger, W Johnson, E Ofili; Zimbabwe: J Chifamba*, University of Zimbabwe AJG Hakim.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-10-23T14:13:52Z
dc.date.available.fl_str_mv 2019-10-23T14:13:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv DO, Ron et al. The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. Plos Medicine, v. 8, n. 10, p. 1-10, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36676
dc.identifier.issn.pt_BR.fl_str_mv 1549-1277
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pmed.1001106
dc.identifier.eissn.none.fl_str_mv 1549-1676
identifier_str_mv DO, Ron et al. The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. Plos Medicine, v. 8, n. 10, p. 1-10, 2011.
1549-1277
10.1371/journal.pmed.1001106
1549-1676
url https://www.arca.fiocruz.br/handle/icict/36676
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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